Prognostic value of corpus callosum injuries in severe head trauma

• Published in: Acta neurochirurgica Vol. 159; no. 1; pp. 25 - 32
• Main Authors: Cicuendez, Marta, Castaño-León, Ana, Ramos, Ana, Hilario, Amaya, Gómez, Pedro A., Lagares, Alfonso
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 2017; Springer Nature B.V
• Subjects: Adult; Corpus Callosum - diagnostic imaging; Corpus Callosum - injuries; Craniocerebral Trauma - complications; Craniocerebral Trauma - diagnosis; Craniocerebral Trauma - diagnostic imaging; Diffuse Axonal Injury - diagnosis; Diffuse Axonal Injury - diagnostic imaging; Female; Humans; Interventional Radiology; Magnetic Resonance Imaging; Male; Medicine; Medicine & Public Health; Middle Aged; Minimally Invasive Surgery; Neurology; Neuroradiology; Neurosurgery; Original Article - Brain Injury; Prognosis; Retrospective Studies; Surgical Orthopedics; Severe head trauma; Traumatic brain injury; Traumatic axonal injury; Magnetic resonance imaging; Corpus callosum injury
• ISSN: 0001-6268; 0942-0940
• DOI: 10.1007/s00701-016-3000-4

Background
This study was performed to investigate the relationship between corpus callosum (CC) injury and prognosis in traumatic axonal injury (TAI).
Method
We retrospectively reviewed 264 patients with severe head trauma who underwent a conventional MR imaging in the first 60 days after injury. They were selected from a prospectively collected database of 1048 patients with severe head trauma admitted in our hospital. TAI lesions were defined as areas of increased signal intensity on T2 and FLAIR or areas of decreased signal on gradient-echo T2. We attempted to determine whether any MR imaging findings of TAI lesions at CC could be related to prognosis. Neurological impairment was assessed at 1 year after injury by means of GOS-E (good outcome being GOS-E 4/5 and bad outcome being GOS-E <4). We adjusted the multivariable analysis for the prognostic factors according to the IMPACT studies: the Core model (age, motor score at admission, and pupillary reactivity) and the Extended model (including CT information and second insults).
Results
We found 97 patients (37 %) with TAI at CC and 167 patients (63 %) without CC lesions at MR. A total of 62 % of the patients with CC lesions had poor outcome, whereas 38 % showed good prognosis. The presence of TAI lesions at the corpus callosum was associated with poor outcome 1 year after brain trauma (
p
 < 0.001, OR 3.8, 95 % CI: 2.04–7.06). The volume of CC lesions measured on T2 and FLAIR sequences was negatively correlated with the GOS-E after adjustment for independent prognostic factors (
p
 = 0.01, OR 2.23, 95 % CI:1.17–4.26). Also the presence of lesions at splenium was statistically related to worse prognosis (p = 0.002, OR 8.1, 95 % CI: 2.2–29.82). We did not find statistical significance in outcome between hemorrhagic and non-hemorrhagic CC lesions.
Conclusions
The presence of CC is associated with a poor outcome. The total volume of the CC lesion is an independent prognostic factor for poor outcome in severe head trauma.