The predictor of mortality outcome in adult patients with Ebola virus disease during the 2014–2015 outbreak in Guinea

• Published in: European journal of clinical microbiology & infectious diseases Vol. 36; no. 4; pp. 689 - 695
• Main Authors: Cherif, M. S., Koonrungsesomboon, N., Diallo, M. P., Le Gall, E., Kassé, D., Cherif, F., Koné, A., Diakité, M., Camara, F., Magassouba, N.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-04-2017; Springer Nature B.V
• Subjects: Adult; Age Factors; Aged; Aged, 80 and over; Biomarkers - analysis; Biomedical and Life Sciences; Biomedicine; Disease Outbreaks; Ebola virus; Ebolavirus; Epidemics; Fatalities; Female; Fever; Guinea - epidemiology; Hemorrhagic Fever, Ebola - diagnosis; Hemorrhagic Fever, Ebola - epidemiology; Hemorrhagic Fever, Ebola - mortality; Hemorrhagic Fever, Ebola - pathology; Humans; Infectious diseases; Internal Medicine; Male; Medical Microbiology; Middle Aged; Mortality; Multivariate analysis; Observational studies; Original Article; Outbreaks; Patients; Prognosis; Public health; Regression analysis; Retrospective Studies; Risk Factors; Survival Analysis; Young Adult; Conakry Guinea; Retrospective Observational Study; Case Fatality Rate; Mortality Outcome; Reverse Transcription Polymerase Chain Reaction; Sporadic Outbreak
• ISSN: 0934-9723; 1435-4373
• DOI: 10.1007/s10096-016-2850-2

The purpose of this study was to examine the association of any demographic and clinical factors with mortality outcome among adult patients with Ebola virus disease (EVD) in Guinea. This retrospective observational study analyzed medical records of laboratory confirmed EVD adult patients during the 2014–2015 EVD outbreak in Guinea. The associations between any demographic or clinical variables and mortality outcome of EVD were assessed using univariate and multivariate logistic regression analyses. Of 2,310 EVD adult patients included for analysis, the overall case fatality rate was 68.1%. Univariate analyses identified factors possibly associated with mortality outcome, including patient age (
p
 < 0.001), history of visiting or close contact with a suspected or confirmed EVD patient (
p
 = 0.035), and seven clinical symptoms on admission, i.e., fever (
p
 = 0.003), hiccups (
p
 < 0.001), vomiting (
p
 = 0.003), diarrhea (
p
 < 0.001), cough (
p
 = 0.001), sore throat (
p
 = 0.016), and unexplained bleeding (
p
 = 0.021). The multivariate analysis showed that patient age was independently associated with mortality outcome of EVD (OR = 1.06; 95%CI = 1.03–1.09;
p
 < 0.001), while none the of clinical symptoms on admission were significantly associated with the mortality outcome. Our analysis indicates that older age was the only independent factor associated with death among EVD adult patients in Guinea. This suggests that older EVD patients should receive intensive medical care and be carefully monitored.