Chlamydia trachomatis infection and human papillomavirus in women with cervical neoplasia in Pernambuco-Brazil

• Published in: Molecular biology reports Vol. 41; no. 2; pp. 865 - 874
• Main Authors: Tavares, Mayara Costa Mansur, de Macêdo, Jamilly Lopes, de Lima Júnior, Sérgio Ferreira, de Andrade Heráclio, Sandra, Amorim, Melânia Maria Ramos, de Mascena Diniz Maia, Maria, de Souza, Paulo Roberto Eleutério
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01-02-2014; Springer Nature B.V
• Subjects: Adolescent; Adult; Aged; Animal Anatomy; Animal Biochemistry; Animals; Biomedical and Life Sciences; Brazil; Cervical cancer; Chlamydia Infections - epidemiology; Chlamydia Infections - pathology; Chlamydia Infections - virology; Chlamydia trachomatis; Chlamydia trachomatis - isolation & purification; Chlamydia trachomatis - pathogenicity; Coinfection; Female; Genotype; Health risk assessment; Histology; Human papillomavirus; Humans; Life Sciences; Middle Aged; Morphology; Papillomaviridae - genetics; Papillomaviridae - pathogenicity; Papillomavirus Infections - genetics; Papillomavirus Infections - pathology; Sexually transmitted diseases; STD; Uterine Cervical Neoplasms - epidemiology; Uterine Cervical Neoplasms - pathology; Uterine Cervical Neoplasms - virology; Brazil; Brazilian population; Abnormal cytology; Human papillomavirus; Risk factors
• DOI: 10.1007/s11033-013-2927-2
• EISSN: 1573-4978
• ISSN: 0301-4851

Chlamydia trachomatis
(CT) is the most common bacterial cause of sexually transmitted disease. High-risk human papillomavirus (HR-HPV) is considered the main etiological agent for cervical neoplasia. Evidences showed that the presence of co-infection of CT and HR-HPV plays a central role in the etiology of cervical intraepithelial neoplasia (CIN) and cervical cancer. The goals of this study were: evaluate the human papillomavirus (HPV) and CT prevalence among Brazilian women with abnormal cytology and provide the effect of this association on the severity of cervical neoplasia. The population of this study was composed by 142 women with incident histological incidence of CIN grades I, II, III or cervical cancer from Recife, Northeast of Brazil. The polymerase chain reaction method on a cervical brush specimen was used to detect both agents and the automatic sequencing method was used for HPV genotyping assay. The prevalence of HPV and CT was 100 and 24.65 %, respectively. Thirteen types of HPV were detected; HPV 16, 18, 31 and 33 were the most common. The most prevalent HPV types were HPV 16 and 18. A significant association between CT positive and HPV 16 infection was found (
p
 < 0.0106; OR = 5.31; 95 % IC 1.59–17.67). In the study population, there was diversity of HPV infections, with high-risk types being the most common. Also, the data collected suggest that CT infection may play an important role in the natural history of HPV infection.