Induction of the Male-Specific Cytochrome P450 3A2 in Female Rats by Phenytoin

We previously reported that administration of dexamethasone (DEX) and other selected pharmacological agents to rats resulted in a profound increase in hepatic cytochrome P450 3A1 in both sexes, but male constitutive P450 3A2 was modestly increased (4-fold) in adult males and not detected in either t...

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Bibliographic Details
Published in:	Archives of biochemistry and biophysics Vol. 332; no. 1; pp. 153 - 162
Main Authors:	Ghosal, Anima, Sadrieh, Nakissa, Reik, Linda, Levin, Wayne, Thomas, Paul E.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-08-1996
Subjects:	Animals Antibodies, Monoclonal Anticonvulsants - pharmacology Aryl Hydrocarbon Hydroxylases Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - analysis Cytochrome P-450 Enzyme System - biosynthesis Cytochrome P-450 Enzyme System - genetics Dexamethasone - pharmacology Enzyme Induction - drug effects Female Glucocorticoids - pharmacology Male Microsomes, Liver - drug effects Microsomes, Liver - enzymology Mixed Function Oxygenases - analysis Phenytoin - pharmacology Rats Rats, Sprague-Dawley RNA, Messenger - genetics RNA, Messenger - metabolism Sex Characteristics Steroid 16-alpha-Hydroxylase Steroid Hydroxylases - analysis Steroid Hydroxylases - biosynthesis Steroid Hydroxylases - genetics Testosterone - metabolism
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