Age-Related Effects of Inhalational Anesthetics in B4galnt1 -Null and Cuprizone-Treated Mice: Clinically Relevant Insights into Demyelinating Diseases
Anesthetics are essential agents that are frequently used in clinical practice to induce a reversible loss of consciousness and sensation by depressing the central nervous system. The inhalational anesthetics isoflurane and sevoflurane are preferred due to their rapid induction and recovery times an...
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| Published in: | Current issues in molecular biology Vol. 46; no. 8; pp. 8376 - 8394 |
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| Main Authors: | , , , , , , |
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| Abstract | Anesthetics are essential agents that are frequently used in clinical practice to induce a reversible loss of consciousness and sensation by depressing the central nervous system. The inhalational anesthetics isoflurane and sevoflurane are preferred due to their rapid induction and recovery times and ease of administration. Despite their widespread use, the exact molecular mechanisms by which these anesthetics induce anesthesia are not yet fully understood. In this study, the age-dependent effects of inhalational anesthetics on two demyelination models were investigated: congenital (
-null) and chemically induced (cuprizone). Various motor and cognitive tests were used to determine sensitivity to isoflurane and sevoflurane anesthesia.
-null mice, which exhibit severe motor deficits due to defects in ganglioside synthesis, showed significant impairments in motor coordination and balance in all motor tests, which were exacerbated by both anesthetics. Cuprizone-treated mice, which mimic the demyelination in
-null mice, also showed altered, age-dependent sensitivity to anesthesia. The study showed that older mice exhibited more pronounced deficits, with
-null mice showing the greatest susceptibility to sevoflurane. These differential responses to anesthetics suggest that age and underlying myelin pathology significantly influence anesthetic effects. |
|---|---|
| AbstractList | Anesthetics are essential agents that are frequently used in clinical practice to induce a reversible loss of consciousness and sensation by depressing the central nervous system. The inhalational anesthetics isoflurane and sevoflurane are preferred due to their rapid induction and recovery times and ease of administration. Despite their widespread use, the exact molecular mechanisms by which these anesthetics induce anesthesia are not yet fully understood. In this study, the age-dependent effects of inhalational anesthetics on two demyelination models were investigated: congenital (
-null) and chemically induced (cuprizone). Various motor and cognitive tests were used to determine sensitivity to isoflurane and sevoflurane anesthesia.
-null mice, which exhibit severe motor deficits due to defects in ganglioside synthesis, showed significant impairments in motor coordination and balance in all motor tests, which were exacerbated by both anesthetics. Cuprizone-treated mice, which mimic the demyelination in
-null mice, also showed altered, age-dependent sensitivity to anesthesia. The study showed that older mice exhibited more pronounced deficits, with
-null mice showing the greatest susceptibility to sevoflurane. These differential responses to anesthetics suggest that age and underlying myelin pathology significantly influence anesthetic effects. Anesthetics are essential agents that are frequently used in clinical practice to induce a reversible loss of consciousness and sensation by depressing the central nervous system. The inhalational anesthetics isoflurane and sevoflurane are preferred due to their rapid induction and recovery times and ease of administration. Despite their widespread use, the exact molecular mechanisms by which these anesthetics induce anesthesia are not yet fully understood. In this study, the age-dependent effects of inhalational anesthetics on two demyelination models were investigated: congenital (B4galnt1-null) and chemically induced (cuprizone). Various motor and cognitive tests were used to determine sensitivity to isoflurane and sevoflurane anesthesia. B4galnt1-null mice, which exhibit severe motor deficits due to defects in ganglioside synthesis, showed significant impairments in motor coordination and balance in all motor tests, which were exacerbated by both anesthetics. Cuprizone-treated mice, which mimic the demyelination in B4galnt1-null mice, also showed altered, age-dependent sensitivity to anesthesia. The study showed that older mice exhibited more pronounced deficits, with B4galnt1-null mice showing the greatest susceptibility to sevoflurane. These differential responses to anesthetics suggest that age and underlying myelin pathology significantly influence anesthetic effects. Anesthetics are essential agents that are frequently used in clinical practice to induce a reversible loss of consciousness and sensation by depressing the central nervous system. The inhalational anesthetics isoflurane and sevoflurane are preferred due to their rapid induction and recovery times and ease of administration. Despite their widespread use, the exact molecular mechanisms by which these anesthetics induce anesthesia are not yet fully understood. In this study, the age-dependent effects of inhalational anesthetics on two demyelination models were investigated: congenital (B4galnt1-null) and chemically induced (cuprizone). Various motor and cognitive tests were used to determine sensitivity to isoflurane and sevoflurane anesthesia. B4galnt1-null mice, which exhibit severe motor deficits due to defects in ganglioside synthesis, showed significant impairments in motor coordination and balance in all motor tests, which were exacerbated by both anesthetics. Cuprizone-treated mice, which mimic the demyelination in B4galnt1-null mice, also showed altered, age-dependent sensitivity to anesthesia. The study showed that older mice exhibited more pronounced deficits, with B4galnt1-null mice showing the greatest susceptibility to sevoflurane. These differential responses to anesthetics suggest that age and underlying myelin pathology significantly influence anesthetic effects.Anesthetics are essential agents that are frequently used in clinical practice to induce a reversible loss of consciousness and sensation by depressing the central nervous system. The inhalational anesthetics isoflurane and sevoflurane are preferred due to their rapid induction and recovery times and ease of administration. Despite their widespread use, the exact molecular mechanisms by which these anesthetics induce anesthesia are not yet fully understood. In this study, the age-dependent effects of inhalational anesthetics on two demyelination models were investigated: congenital (B4galnt1-null) and chemically induced (cuprizone). Various motor and cognitive tests were used to determine sensitivity to isoflurane and sevoflurane anesthesia. B4galnt1-null mice, which exhibit severe motor deficits due to defects in ganglioside synthesis, showed significant impairments in motor coordination and balance in all motor tests, which were exacerbated by both anesthetics. Cuprizone-treated mice, which mimic the demyelination in B4galnt1-null mice, also showed altered, age-dependent sensitivity to anesthesia. The study showed that older mice exhibited more pronounced deficits, with B4galnt1-null mice showing the greatest susceptibility to sevoflurane. These differential responses to anesthetics suggest that age and underlying myelin pathology significantly influence anesthetic effects. Anesthetics are essential agents that are frequently used in clinical practice to induce a reversible loss of consciousness and sensation by depressing the central nervous system. The inhalational anesthetics isoflurane and sevoflurane are preferred due to their rapid induction and recovery times and ease of administration. Despite their widespread use, the exact molecular mechanisms by which these anesthetics induce anesthesia are not yet fully understood. In this study, the age-dependent effects of inhalational anesthetics on two demyelination models were investigated: congenital ( B4galnt1 -null) and chemically induced (cuprizone). Various motor and cognitive tests were used to determine sensitivity to isoflurane and sevoflurane anesthesia. B4galnt1 -null mice, which exhibit severe motor deficits due to defects in ganglioside synthesis, showed significant impairments in motor coordination and balance in all motor tests, which were exacerbated by both anesthetics. Cuprizone-treated mice, which mimic the demyelination in B4galnt1 -null mice, also showed altered, age-dependent sensitivity to anesthesia. The study showed that older mice exhibited more pronounced deficits, with B4galnt1 -null mice showing the greatest susceptibility to sevoflurane. These differential responses to anesthetics suggest that age and underlying myelin pathology significantly influence anesthetic effects. |
| Author | Milić, Jakov Viljetić, Barbara Rončević, Robert Ivić, Vedrana Mrđenović, Stefan Heffer, Marija Tot, Ozana Katarina |
| AuthorAffiliation | 2 Department of Anesthesiology, Resuscitation, Intensive Care Medicine and Pain Management, Faculty of Medicine Osijek, Josip Juraj Strossmayer University, 31000 Osijek, Croatia 5 Department of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University, 31000 Osijek, Croatia; vedrana.ivic@mefos.hr (V.I.); milic.jakov@gmail.com (J.M.); mheffer@mefos.hr (M.H.) 1 Department of Anesthesiology, Resuscitation and Intensive Care, University Hospital Center Osijek, 31000 Osijek, Croatia; oktot@mefos.hr 3 Department of Hematology, Internal Medicine Clinic, University Hospital Center Osijek, 31000 Osijek, Croatia; mrdenovic@gmail.com 7 Department of Medical Chemistry, Biochemistry and Clinical Chemistry, Faculty of Medicine Osijek, Josip Juraj Strossmayer University, 31000 Osijek, Croatia 4 Department of Internal Medicine and History of Medicine, Faculty of Medicine Osijek, Josip Juraj Strossmayer University, 31000 Osijek, Croatia 6 Department of Diagnostic and Interv |
| AuthorAffiliation_xml | – name: 3 Department of Hematology, Internal Medicine Clinic, University Hospital Center Osijek, 31000 Osijek, Croatia; mrdenovic@gmail.com – name: 7 Department of Medical Chemistry, Biochemistry and Clinical Chemistry, Faculty of Medicine Osijek, Josip Juraj Strossmayer University, 31000 Osijek, Croatia – name: 4 Department of Internal Medicine and History of Medicine, Faculty of Medicine Osijek, Josip Juraj Strossmayer University, 31000 Osijek, Croatia – name: 6 Department of Diagnostic and Interventional Radiology, University Hospital Center Osijek, 31000 Osijek, Croatia; robert.roncevic27@gmail.com – name: 1 Department of Anesthesiology, Resuscitation and Intensive Care, University Hospital Center Osijek, 31000 Osijek, Croatia; oktot@mefos.hr – name: 2 Department of Anesthesiology, Resuscitation, Intensive Care Medicine and Pain Management, Faculty of Medicine Osijek, Josip Juraj Strossmayer University, 31000 Osijek, Croatia – name: 5 Department of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University, 31000 Osijek, Croatia; vedrana.ivic@mefos.hr (V.I.); milic.jakov@gmail.com (J.M.); mheffer@mefos.hr (M.H.) |
| Author_xml | – sequence: 1 givenname: Ozana Katarina surname: Tot fullname: Tot, Ozana Katarina organization: Department of Anesthesiology, Resuscitation, Intensive Care Medicine and Pain Management, Faculty of Medicine Osijek, Josip Juraj Strossmayer University, 31000 Osijek, Croatia – sequence: 2 givenname: Stefan orcidid: 0000-0001-6993-7801 surname: Mrđenović fullname: Mrđenović, Stefan organization: Department of Internal Medicine and History of Medicine, Faculty of Medicine Osijek, Josip Juraj Strossmayer University, 31000 Osijek, Croatia – sequence: 3 givenname: Vedrana orcidid: 0000-0002-8185-1960 surname: Ivić fullname: Ivić, Vedrana organization: Department of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University, 31000 Osijek, Croatia – sequence: 4 givenname: Robert orcidid: 0000-0001-6952-5903 surname: Rončević fullname: Rončević, Robert organization: Department of Diagnostic and Interventional Radiology, University Hospital Center Osijek, 31000 Osijek, Croatia – sequence: 5 givenname: Jakov orcidid: 0000-0003-2543-2857 surname: Milić fullname: Milić, Jakov organization: Department of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University, 31000 Osijek, Croatia – sequence: 6 givenname: Barbara surname: Viljetić fullname: Viljetić, Barbara organization: Department of Medical Chemistry, Biochemistry and Clinical Chemistry, Faculty of Medicine Osijek, Josip Juraj Strossmayer University, 31000 Osijek, Croatia – sequence: 7 givenname: Marija orcidid: 0000-0001-6770-7359 surname: Heffer fullname: Heffer, Marija organization: Department of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University, 31000 Osijek, Croatia |
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| Cites_doi | 10.1016/j.febslet.2009.10.011 10.1016/bs.pmbts.2017.12.004 10.1016/j.expneurol.2005.04.017 10.1093/glycob/cws103 10.1038/35036052 10.1016/j.celrep.2016.12.053 10.1002/glia.20503 10.3390/ijms21030868 10.1093/cercor/bhy330 10.1056/NEJMra021261 10.1093/glycob/cwh107 10.1006/exnr.2000.7504 10.1186/s13024-022-00538-8 10.1152/physrev.00033.2013 10.1016/j.tips.2019.05.001 10.1038/s41598-019-55885-2 10.3389/fncel.2014.00073 10.3389/fnins.2010.00272 10.1111/joa.13562 10.1073/pnas.0407785102 10.1073/pnas.96.13.7532 10.4097/kjae.2010.59.1.3 10.1016/j.neulet.2020.134785 10.1590/S0100-879X2003000800006 10.1016/j.expneurol.2011.11.039 10.1038/s41598-018-23335-0 10.1007/BF01153342 10.1194/jlr.TR119000427 10.1097/00000539-200110000-00029 10.1371/journal.pone.0057870 10.1073/pnas.93.20.10662 10.1111/j.1600-0404.2008.01036.x 10.3389/fnins.2020.572965 10.1073/pnas.2004259117 10.1038/ng1095-204 10.1089/neu.1995.12.1 10.1093/cercor/bhs321 10.1093/acprof:oso/9780198525387.001.0001 10.1369/jhc.6A6930.2006 |
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| Keywords | B4galnt1 mice cuprizone inhalational anesthetics demyelination |
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| Title | Age-Related Effects of Inhalational Anesthetics in B4galnt1 -Null and Cuprizone-Treated Mice: Clinically Relevant Insights into Demyelinating Diseases |
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