Anti-inflammatory and antinociceptive activity of arbortristoside-A

• Published in: Journal of ethnopharmacology Vol. 116; no. 1; pp. 198 - 203
• Main Authors: Das, Sanjita, Sasmal, Dinakar, Basu, Saumya Priya
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 28-02-2008; Amsterdam; New York: Elsevier; Elsevier
• Subjects: acute toxicity; analgesic effect; Analgesics - isolation & purification; Analgesics - pharmacology; animal models; Animals; Anti-inflammatory activity; Anti-Inflammatory Agents - isolation & purification; Anti-Inflammatory Agents - pharmacology; Antinociceptive activity; Biological and medical sciences; chemical structure; dosage; dose response; Dose-Response Relationship, Drug; ethanol; General pharmacology; herbal medicines; histamine; intraperitoneal injection; Iridoid Glucosides; Iridoids - isolation & purification; Iridoids - pharmacology; Medical sciences; medicinal plants; medicinal properties; Mice; Nyctanthes arbor-tristis; Nyctanthes arbortristis L; Oleaceae - chemistry; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; plant extracts; Prostaglandin Antagonists - pharmacology; prostaglandins; Rats; Rats, Wistar; seeds; Seeds - chemistry; serotonin; Antinociceptive activity; Anti-inflammatory activity; Nyctanthes arbortristis L; Analgesic; Pharmacognosy; Antiinflammatory agent; Plant origin; Medicinal plant
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/j.jep.2007.11.034

Nyctanthes arbortristis Linn is a well-documented plant. It is evident from literature and previous investigations that
Nyctanthes arbortristis possesses anti-inflammatory and analgesic activity. In the present study arbortristoside-A has been isolated from the ethanolic extract of its seeds. The structure of the isolated compound was determined by chemical reactions and spectroscopic methods. Arbortristoside-A was found to possess significant and dose-dependent anti-inflammatory and antinociceptive activity. It seems arbortristoside-A inhibited the histamine, serotonin and carrageenan-induced edema suggesting its inhibiting effect on carrageenan, arachidonic acid, histamine and serotonin-induced edema suggesting its anti-inflammatory activity may be due to the inhibiting effect of prostaglandin, histamine and serotonin. The analgesic activity of arbortristoside-A may be due to the inhibition of the action of prostaglandin.