Correlation of preoperative magnetic resonance imaging of peritoneal carcinomatosis and clinical outcome after peritonectomy and HIPEC after 3 years of follow-up: preliminary results

• Published in: Cancer imaging Vol. 13; no. 4; pp. 540 - 547
• Main Authors: Klumpp, B, Aschoff, P, Schwenzer, N, Koenigsrainer, I, Beckert, S, Claussen, C D, Miller, S, Koenigsrainer, A, Pfannenberg, C
• Format: Journal Article
• Language: English
• Published: England e-Med 02-01-2014
• Subjects: Adult; Aged; Combined Modality Therapy; Female; Fluorodeoxyglucose F18; Follow-Up Studies; Humans; Hyperthermia, Induced - methods; Magnetic Resonance Imaging - methods; Male; Middle Aged; Original; Peritoneal Neoplasms - mortality; Peritoneal Neoplasms - pathology; Peritoneal Neoplasms - therapy; Peritoneum - surgery; Positron-Emission Tomography; Treatment Outcome
• ISSN: 1470-7330; 1740-5025; 1470-7330
• DOI: 10.1102/1470-7330.2013.0044

In patients with peritoneal carcinomatosis, cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is an evolving approach with curative intention. Previous studies indicate a correlation between preoperative magnetic resonance imaging (MRI) and surgical findings regarding the extent of peritoneal carcinomatosis. The aim of this study was to assess retrospectively whether preoperative MRI can predict the outcome and is therefore a suitable tool for patient selection.
Fifteen patients with laparoscopically proven peritoneal carcinomatosis were preoperatively examined using a 1.5-T whole-body MRI system. Results were correlated with surgical exploration. Follow-up was done by contrast-enhanced abdominal computed tomography and, if suspicious for recurring disease, laparoscopy or laparotomy. Survival time and interval to recurring disease were correlated with the preoperative peritoneal carcinomatosis index (PCI) on MRI (Spearman's rank correlation).
In five patients radical resection could not be achieved (PCI 34 ± 6.9); survival time was 78.2 ± 54.1 days. In seven patients recurring disease was found 430 ± 261.2 days after initial complete cytoreduction (PCI 11.6 ± 6.9); survival time was 765.9 ± 355 days. Two patients are still alive after 3 years. Two patients with initially complete cytoreduction are without recurring disease after 3 years (PCI 5 and 12). One patient was lost for follow-up.
Results of the preoperative MRI correlate well with the surgical PCI, postoperative resection status, and survival time. MRI might be a suitable technique for patient selection when considering peritonectomy and HIPEC. In our patients the outcome seems to correlate well with the extent of peritoneal carcinomatosis found by the preoperative MRI.