Cerebellar modulation of cough motor pattern in cats

• Published in: Journal of applied physiology (1985) Vol. 83; no. 2; pp. 391 - 397
• Main Authors: Xu, Fadi, Frazier, Donald T, Zhang, Zhong, Baekey, David M, Shannon, Roger
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Physiological Soc 01-08-1997; American Physiological Society
• Subjects: Animals; Biological and medical sciences; Cats; Cerebellar Nuclei - physiopathology; Cerebellum - physiopathology; Cough - physiopathology; Decerebrate State; Efferent Pathways - physiopathology; Female; Fundamental and applied biological sciences. Psychology; Lumbosacral Plexus - physiopathology; Male; Motor Activity - physiology; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration; Phrenic Nerve - physiopathology; Physical Stimulation; Respiration, Artificial; Trachea - physiology; Vertebrates: nervous system and sense organs; Cerebellum; Fissipedia; Carnivora; Central nervous system; Motor control; Cough; Vertebrata; Mammalia; Fastigial nucleus; Cat; Motor nerve; Respiratory control; Brain (vertebrata)
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/jappl.1997.83.2.391

Fadi
Xu,
Donald T.
Frazier,
Zhong
Zhang,
David M.
Baekey, and
Roger
Shannon
Department of Physiology, University of Kentucky, Lexington,
Kentucky 40536; and Department of Physiology and Biophysics, College of
Medicine, University of South Florida, Tampa, Florida
33612
Received 29 January 1997; accepted in final form 28 March 1997.
Xu, Fadi, Donald T. Frazier, Zhong Zhang, David M. Baekey,
and Roger Shannon. Cerebellar modulation of cough motor pattern in
cats. J. Appl. Physiol. 83(2):
391-397, 1997. The cerebellum modulates respiratory muscle
activity in part via its influence on the central respiratory pattern
generator. Because coughing requires well-coordinated respiratory
muscle activity, studies were conducted to determine whether the
cerebellum influences the centrally generated cough motor pattern.
Integrated phrenic and lumbar efferent neurograms
( PN and LN, respectively)
were monitored in decerebrated, paralyzed, and ventilated cats.
Mechanical probing of the intrathoracic trachea was used to evoke
fictive coughs; i.e., large increases in
PN and LN amplitudes.
Cerebellectomy resulted in a decrease in the number of coughs
per trial (cough frequency) and LN peak
amplitudes without any consistent change in
PN peak amplitudes. Cerebellar nuclei [the
rostral interposed nucleus (INr) and the rostral fastigial nucleus
(FNr)] known to be involved in respiratory control were ablated
to determine their potential role in the cough response. Control
(eupneic) respiratory frequency was not affected by cerebellectomy or
INr/FNr lesions. Cough frequency was depressed by lesion of the INr but
not by ablation of the FNr. No significant changes in
PN and LN amplitudes were
observed after lesion of either the INr or FNr. These results suggest
that the cerebellum, specifically the INr, is involved in modulation of
the frequency of centrally generated coughing.
fastigial nucleus; interposed nucleus; lumbar nerve motor activity; respiratory control; tracheal probing; thermal lesions
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Copyright © 1997 the American Physiological Society