Validation of ultrasonic-assisted switchable solvent liquid phase microextraction for trace determination of hormones and organochlorine pesticides by GC–MS and combination with QuEChERS

• Published in: Food chemistry Vol. 305; p. 125487
• Main Authors: Durak, Büşra Yilmaz, Chormey, Dotse Selali, Firat, Merve, Bakirdere, Sezgin
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-02-2020
• Subjects: Endocrine disruptors; Gas Chromatography-Mass Spectrometry - methods; Hormones; Hormones - analysis; Hormones - isolation & purification; Hydrocarbons, Chlorinated - analysis; Hydrocarbons, Chlorinated - isolation & purification; Limit of Detection; Liquid Phase Microextraction - methods; Pesticide; Pesticides - analysis; Pesticides - isolation & purification; QuEChERS; Solvents - chemistry; Switchable solvent; Ultrasonic Waves; Waste Water - chemistry; Water Pollutants, Chemical - analysis; Water Pollutants, Chemical - isolation & purification; Endocrine disruptors; Hormones; Pesticide; Switchable solvent; QuEChERS
• DOI: 10.1016/j.foodchem.2019.125487
• EISSN: 1873-7072
• ISSN: 0308-8146

QuEChERS and switchable solvent liquid phase microextraction (SS-LPME) were respectively used as pretreatment and preconcentration tools to allow trace determination of selected organochlorine pesticides and hormones by gas chromatography mass spectrometry (GC–MS). The effects of principal SS-LPME variables and their interactions were evaluated with a Box-Behnken experimental design. The limits of detection obtained by direct GC–MS determination were enhanced by about 33–115 folds under the optimized SS-LPME conditions. The SS-LPME method was applied to tap water, well water, lake water, medical wastewater and tea samples. Satisfactory recovery results were obtained for all but the tea samples using the conventional calibration plot. Matrix matched calibration standards were used to improve the percent recovery of analytes to almost 100% in the tea samples. The combined QuEChERS and SS-LPME method was applied to tomato samples and matrix matching was also used to significantly improve analyte recoveries.
•Box-Behnken experimental design was used in the optimization.•Detection powers increased by about 33–115 folds.•Limits of detection were between 0.44 ng/mL and 1.5 ng/mL.•Matrix matching was used to improve analyte recovery.•SS-LPME was used to preconcentrate analytes after QuEChERS.