Cytomegalovirus retinitis in patients with AIDS: current status
About 20%-30% of patients with AIDS will develop cytomegalovirus (CMV) retinitis when they are severely immunodeficient (CD4 cell count below 40 cells/microL). It causes extensive retinal damage with visual deficits, and relapses are frequent. Intravenous ganciclovir and foscarnet are standard thera...
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| Published in: | Medical journal of Australia Vol. 163; no. 9; p. 489 |
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| Format: | Journal Article |
| Language: | English |
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Australia
06-11-1995
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| Abstract | About 20%-30% of patients with AIDS will develop cytomegalovirus (CMV) retinitis when they are severely immunodeficient (CD4 cell count below 40 cells/microL). It causes extensive retinal damage with visual deficits, and relapses are frequent. Intravenous ganciclovir and foscarnet are standard therapy, but their high toxicity and long term intravenous access mean that advances in treatment, including oral prophylactic agents, intravitreal injections and surgical implants, may provide a better quality of life for patients. Prophylactic ophthalmological screening of patients with CD4 cell counts below 100 cells/microL to detect asymptomatic retinitis is needed. |
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| AbstractList | About 20%-30% of patients with AIDS will develop cytomegalovirus (CMV) retinitis when they are severely immunodeficient (CD4 cell count below 40 cells/microL). It causes extensive retinal damage with visual deficits, and relapses are frequent. Intravenous ganciclovir and foscarnet are standard therapy, but their high toxicity and long term intravenous access mean that advances in treatment, including oral prophylactic agents, intravitreal injections and surgical implants, may provide a better quality of life for patients. Prophylactic ophthalmological screening of patients with CD4 cell counts below 100 cells/microL to detect asymptomatic retinitis is needed. |
| Author | Luckie, A P |
| Author_xml | – sequence: 1 givenname: A P surname: Luckie fullname: Luckie, A P organization: Department of Ophthalmology, University of Melbourne, VIC |
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| Snippet | About 20%-30% of patients with AIDS will develop cytomegalovirus (CMV) retinitis when they are severely immunodeficient (CD4 cell count below 40 cells/microL).... |
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| SubjectTerms | AIDS-Related Opportunistic Infections - diagnosis AIDS-Related Opportunistic Infections - drug therapy Antiviral Agents - therapeutic use Cytomegalovirus Retinitis - diagnosis Cytomegalovirus Retinitis - drug therapy Foscarnet - therapeutic use Ganciclovir - therapeutic use Humans |
| Title | Cytomegalovirus retinitis in patients with AIDS: current status |
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