Asymmetric Suzuki-Miyaura Coupling in Water with a Chiral Palladium Catalyst Supported on an Amphiphilic Resin

Asymmetric Suzuki-Miyaura Coupling in Water with a Chiral Palladium Catalyst Supported on an Amphiphilic Resin

You oughta use water: Broad functional-group (FG) tolerance was observed for the title coupling of aryl halides (X=Cl, Br, I) and aryl boronic acids to give biaryl compounds with up to 94 % ee. The chiral imidazoindole phosphine-palladium catalyst supported on an amphiphilic polystyrene-poly(ethylen...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) Vol. 48; no. 15; pp. 2708 - 2710
Main Authors: Uozumi, Yasuhiro, Matsuura, Yutaka, Arakawa, Takayasu, Yamada, Yoichi M.A
Format: Journal Article
Language:English
Published: Weinheim Wiley-VCH Verlag 30-03-2009
WILEY-VCH Verlag
WILEY‐VCH Verlag
Subjects:
asymmetric catalysis
biaryls
cross-coupling
heterogeneous catalysis
water
Online Access:Get full text
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Summary:You oughta use water: Broad functional-group (FG) tolerance was observed for the title coupling of aryl halides (X=Cl, Br, I) and aryl boronic acids to give biaryl compounds with up to 94 % ee. The chiral imidazoindole phosphine-palladium catalyst supported on an amphiphilic polystyrene-poly(ethylene glycol) (PS-PEG) resin could be recycled readily.
Bibliography:http://dx.doi.org/10.1002/anie.200900469
MEXT
istex:140641F569E199696DAE0B4BF7D7B6864CBFBE62
We thank the MEXT (Scientific Research on Priority Areas) and the METI GSC Project for partial financial support of this research.
ark:/67375/WNG-47Q6D4PL-P
ArticleID:ANIE200900469
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200900469