Cognitive Impairment in Multiple Sclerosis
Multiple sclerosis (MS) is a socially significant immune-mediated disease, characterized by demyelination, axonal transection and oligodendropathy in the central nervous system. Inflammatory demyelination and neurodegeneration lead to brain atrophy and cognitive deficit in up to 75% of the patients....
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| Published in: | Folia Medica Vol. 58; no. 3; pp. 157 - 163 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
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Bulgaria
MEDICAL UNIVERSITY- PLOVDIV
01-09-2016
Pensoft Publishers |
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| Abstract | Multiple sclerosis (MS) is a socially significant immune-mediated disease, characterized by demyelination, axonal transection and oligodendropathy in the central nervous system. Inflammatory demyelination and neurodegeneration lead to brain atrophy and cognitive deficit in up to 75% of the patients. Cognitive dysfunctions impact significantly patients' quality of life, independently from the course and phase of the disease. The relationship between pathological brain findings and cognitive impairment is a subject of intensive research. Summarizing recent data about prevalence, clinical specificity and treatment of cognitive disorders in MS, this review aims to motivate the necessity of early diagnosis and complex therapeutic approach to these disturbances in order to reduce the social burden of the disease. |
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| AbstractList | Multiple sclerosis (MS) is a socially significant immune-mediated disease, characterized by demyelination, axonal transection and oligodendropathy in the central nervous system. Inflammatory demyelination and neurodegeneration lead to brain atrophy and cognitive deficit in up to 75% of the patients. Cognitive dysfunctions impact significantly patients' quality of life, independently from the course and phase of the disease. The relationship between pathological brain findings and cognitive impairment is a subject of intensive research. Summarizing recent data about prevalence, clinical specificity and treatment of cognitive disorders in MS, this review aims to motivate the necessity of early diagnosis and complex therapeutic approach to these disturbances in order to reduce the social burden of the disease. Multiple sclerosis (MS) is a socially significant immune-mediated disease, characterized by demyelination, axonal transection and oligodendropathy in the central nervous system. Inflammatory demyelination and neurodegeneration lead to brain atrophy and cognitive deficit in up to 75% of the patients. Cognitive dysfunctions impact significantly patients’ quality of life, independently from the course and phase of the disease. |
| Author | Aksentieva, Jana B Manova, Maria G Stanilova, Spaska A Miteva, Lyuba D Trenova, Anastasiya G Slavov, Georgi S |
| Author_xml | – sequence: 1 givenname: Anastasiya G surname: Trenova fullname: Trenova, Anastasiya G organization: Department of Neurology, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria – sequence: 2 givenname: Georgi S surname: Slavov fullname: Slavov, Georgi S organization: Department of Neurology, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria – sequence: 3 givenname: Maria G surname: Manova fullname: Manova, Maria G organization: Department of Neurology, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria – sequence: 4 givenname: Jana B surname: Aksentieva fullname: Aksentieva, Jana B organization: Department of Neurology, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria – sequence: 5 givenname: Lyuba D surname: Miteva fullname: Miteva, Lyuba D organization: Department of Molecular Biology, Immunology and Medical Genetics, Trakia University, Stara Zagora, Bulgaria – sequence: 6 givenname: Spaska A surname: Stanilova fullname: Stanilova, Spaska A organization: Department of Molecular Biology, Immunology and Medical Genetics, Trakia University, Stara Zagora, Bulgaria |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27760012$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Central Nervous System - pathology Cognitive Dysfunction - etiology Cognitive Dysfunction - pathology Cognitive Dysfunction - therapy cognitive impairment Disease Progression Humans multiple sclerosis Multiple Sclerosis - complications Multiple Sclerosis - pathology neuropsychological tests Quality of Life |
| Title | Cognitive Impairment in Multiple Sclerosis |
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