Development of a Universal Epitope-Based Influenza Vaccine and Evaluation of Its Effectiveness in Mice
Vaccination is an effective and economically viable means of protection against the influenza virus, but due to rapid viral evolution, modern seasonal vaccines are not effective enough. Next-generation vaccines are designed to provide protection against a wide range of influenza virus strains, inclu...
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| Published in: | Vaccines (Basel) Vol. 10; no. 4; p. 534 |
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| Abstract | Vaccination is an effective and economically viable means of protection against the influenza virus, but due to rapid viral evolution, modern seasonal vaccines are not effective enough. Next-generation vaccines are designed to provide protection against a wide range of influenza virus strains, including pandemic variants. In our work, we made an epitope-based universal vaccine, rMVA-k1-k2, against the influenza virus based on the modified vaccinia Ankara (MVA) vector and using our own algorithms to select epitopes from conserved fragments of the NP, M1 and HA proteins of influenza A and B. We show that double immunization protects mice with a 67% or greater efficiency against viral influenza pneumonia when infected with various strains of the H1N1, H2N2, H3N2 and H5N1 subtypes of influenza A. In animals, the level of protection provided by the rMVA-k1-k2 vaccine was comparable to that provided by the universal M001 and MVA-NP+M1 (Invictus) vaccines, which have shown success in clinical trials, against strains of the H1N1 and H3N2 subtypes. |
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| AbstractList | Vaccination is an effective and economically viable means of protection against the influenza virus, but due to rapid viral evolution, modern seasonal vaccines are not effective enough. Next-generation vaccines are designed to provide protection against a wide range of influenza virus strains, including pandemic variants. In our work, we made an epitope-based universal vaccine, rMVA-k1-k2, against the influenza virus based on the modified vaccinia Ankara (MVA) vector and using our own algorithms to select epitopes from conserved fragments of the NP, M1 and HA proteins of influenza A and B. We show that double immunization protects mice with a 67% or greater efficiency against viral influenza pneumonia when infected with various strains of the H1N1, H2N2, H3N2 and H5N1 subtypes of influenza A. In animals, the level of protection provided by the rMVA-k1-k2 vaccine was comparable to that provided by the universal M001 and MVA-NP+M1 (Invictus) vaccines, which have shown success in clinical trials, against strains of the H1N1 and H3N2 subtypes. |
| Author | Shipulin, German A Mintaev, Ramil R Bogoslovskaya, Elena V Orlova, Olga V Glazkova, Dina V |
| AuthorAffiliation | 2 I. Mechnikov Research Institute of Vaccines and Sera, 105064 Moscow, Russia 1 Center for Strategic Planning and Management of Medical and Biological Health Risks, Federal State Budgetary Institution, Federal Medical-Biological Agency, 119833 Moscow, Russia; georgin2702@gmail.com (D.V.G.); orlovaov@gmail.com (O.V.O.); lenabo2@mail.ru (E.V.B.); shipgerman@gmail.com (G.A.S.) |
| AuthorAffiliation_xml | – name: 1 Center for Strategic Planning and Management of Medical and Biological Health Risks, Federal State Budgetary Institution, Federal Medical-Biological Agency, 119833 Moscow, Russia; georgin2702@gmail.com (D.V.G.); orlovaov@gmail.com (O.V.O.); lenabo2@mail.ru (E.V.B.); shipgerman@gmail.com (G.A.S.) – name: 2 I. Mechnikov Research Institute of Vaccines and Sera, 105064 Moscow, Russia |
| Author_xml | – sequence: 1 givenname: Ramil R surname: Mintaev fullname: Mintaev, Ramil R organization: I. Mechnikov Research Institute of Vaccines and Sera, 105064 Moscow, Russia – sequence: 2 givenname: Dina V surname: Glazkova fullname: Glazkova, Dina V organization: Center for Strategic Planning and Management of Medical and Biological Health Risks, Federal State Budgetary Institution, Federal Medical-Biological Agency, 119833 Moscow, Russia – sequence: 3 givenname: Olga V surname: Orlova fullname: Orlova, Olga V organization: Center for Strategic Planning and Management of Medical and Biological Health Risks, Federal State Budgetary Institution, Federal Medical-Biological Agency, 119833 Moscow, Russia – sequence: 4 givenname: Elena V surname: Bogoslovskaya fullname: Bogoslovskaya, Elena V organization: Center for Strategic Planning and Management of Medical and Biological Health Risks, Federal State Budgetary Institution, Federal Medical-Biological Agency, 119833 Moscow, Russia – sequence: 5 givenname: German A surname: Shipulin fullname: Shipulin, German A organization: Center for Strategic Planning and Management of Medical and Biological Health Risks, Federal State Budgetary Institution, Federal Medical-Biological Agency, 119833 Moscow, Russia |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35455283$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1371/journal.pone.0064555 10.1093/nar/gkw857 10.1073/pnas.1322229111 10.1186/1471-2334-9-129 10.1038/s41598-019-40175-8 10.1126/science.aac7263 10.1007/s00253-018-8986-5 10.1016/S0140-6736(17)33293-2 10.1016/0264-410X(95)00014-R 10.1093/cid/cis327 10.4161/hv.25598 10.1016/j.vaccine.2019.07.033 10.1111/j.1365-2249.2007.03340.x 10.1016/j.vaccine.2012.10.084 10.1093/infdis/jix632 10.3201/eid1201.051254 10.1097/MD.0000000000006339 10.1073/pnas.80.3.840 10.3390/v12101186 10.1128/JVI.01047-08 10.1111/j.1365-2567.2006.02421.x 10.4049/jimmunol.171.6.3163 10.1093/bib/bbx108 10.1073/pnas.1105624108 10.4049/jimmunol.154.2.703 10.1128/JVI.79.12.7380-7388.2005 10.1002/biot.201400393 10.1186/s12864-019-6311-z 10.1038/s41573-019-0056-x 10.1371/journal.pone.0155340 10.1093/infdis/jiv534 10.1007/978-1-61779-876-4_4 10.1016/j.vaccine.2016.10.040 10.1016/0198-8859(96)00117-6 10.4049/jimmunol.161.4.1599 10.1002/0471142735.im1911s42 10.3109/08820138409061305 10.1016/j.vaccine.2020.01.088 10.1093/oxfordjournals.aje.a118408 10.3201/eid1201.051147 10.1093/cid/ciq015 10.1093/bioinformatics/btp033 10.1142/S021972001441008X 10.1016/j.vaccine.2014.08.031 10.1016/j.jviromet.2020.114056 10.1002/prot.340110408 |
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| Keywords | influenza MVA universal vaccine epitope |
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| References | McCabe (ref_24) 2020; 48 Eickhoff (ref_49) 2019; 37 Impagliazzo (ref_11) 2015; 349 ref_54 ref_52 Bajic (ref_55) 2019; 9 Sicca (ref_56) 2020; 38 Kilbourne (ref_58) 2006; 12 ref_19 ref_15 Atsmon (ref_53) 2014; 32 Moise (ref_45) 2013; 9 Yun (ref_39) 1995; 13 Knossow (ref_35) 2006; 119 Liu (ref_9) 2016; 34 ref_23 Grant (ref_47) 2014; 111 ref_22 Berkhoff (ref_48) 2007; 148 Spackman (ref_34) 2014; 1161 Reed (ref_26) 1938; 27 Liu (ref_14) 2017; 96 Cottey (ref_33) 2001; 42 ref_29 Luke (ref_59) 2006; 12 Kremer (ref_25) 2012; 890 Atassi (ref_40) 1983; 80 Iuliano (ref_1) 2018; 39 Wei (ref_7) 2020; 19 Krammer (ref_3) 2015; 10 Guo (ref_37) 2018; 16 ref_32 ref_31 Lillie (ref_13) 2012; 55 ref_30 Russell (ref_36) 1998; 161 Terajima (ref_50) 2008; 82 Robbins (ref_51) 1995; 154 Shenkin (ref_20) 1991; 11 ref_38 Katoh (ref_17) 2019; 20 Mintaev (ref_21) 2014; 12 Atassi (ref_41) 1984; 13 Danke (ref_46) 2003; 171 Berthoud (ref_12) 2011; 52 Zeliszewski (ref_44) 1996; 50 Zhang (ref_16) 2017; 45 Waterhouse (ref_18) 2009; 25 You (ref_28) 2018; 102 ref_42 DiazGranados (ref_4) 2012; 31 Orlova (ref_27) 2021; 289 Bianchi (ref_43) 2005; 79 ref_2 Wu (ref_10) 2011; 108 ref_8 ref_5 Young (ref_6) 2018; 217 Viboud (ref_57) 2016; 213 |
| References_xml | – ident: ref_42 doi: 10.1371/journal.pone.0064555 – ident: ref_5 – ident: ref_32 – volume: 45 start-page: D466 year: 2017 ident: ref_16 article-title: Influenza Research Database: An integrated bioinformatics resource for influenza virus research publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkw857 contributor: fullname: Zhang – volume: 111 start-page: 1049 year: 2014 ident: ref_47 article-title: Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1322229111 contributor: fullname: Grant – ident: ref_2 doi: 10.1186/1471-2334-9-129 – volume: 9 start-page: 3492 year: 2019 ident: ref_55 article-title: Autoreactivity profiles of influenza hemagglutinin broadly neutralizing antibodies publication-title: Sci. Rep. doi: 10.1038/s41598-019-40175-8 contributor: fullname: Bajic – volume: 349 start-page: 1301 year: 2015 ident: ref_11 article-title: Stable trimeric influenza hemagglutinin stem as a broadly protective immunogen publication-title: Science doi: 10.1126/science.aac7263 contributor: fullname: Impagliazzo – volume: 102 start-page: 5953 year: 2018 ident: ref_28 article-title: Efficient mAb production in CHO cells with optimized signal peptide, codon, and UTR publication-title: Appl. Microbiol. Biotechnol. doi: 10.1007/s00253-018-8986-5 contributor: fullname: You – volume: 39 start-page: 1285 year: 2018 ident: ref_1 article-title: Estimates of global seasonal influenza-associated respiratory mortality: A modelling study publication-title: Lancet doi: 10.1016/S0140-6736(17)33293-2 contributor: fullname: Iuliano – volume: 13 start-page: 927 year: 1995 ident: ref_39 article-title: Protection of mice against lethal viral infection by synthetic peptides corresponding to B- and T-cell recognition sites of influenza A hemagglutinin publication-title: Vaccine doi: 10.1016/0264-410X(95)00014-R contributor: fullname: Yun – volume: 55 start-page: 19 year: 2012 ident: ref_13 article-title: Preliminary assessment of the efficacy of a T-cell-based influenza vaccine, MVA-NP+M1, in humans publication-title: Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am. doi: 10.1093/cid/cis327 contributor: fullname: Lillie – volume: 9 start-page: 1598 year: 2013 ident: ref_45 article-title: Universal H1N1 influenza vaccine development: Identification of consensus class II hemagglutinin and neuraminidase epitopes derived from strains circulating between 1980 and 2011 publication-title: Hum. Vaccines Immunother. doi: 10.4161/hv.25598 contributor: fullname: Moise – ident: ref_23 – volume: 37 start-page: 5371 year: 2019 ident: ref_49 article-title: Highly conserved influenza T cell epitopes induce broadly protective immunity publication-title: Vaccine doi: 10.1016/j.vaccine.2019.07.033 contributor: fullname: Eickhoff – volume: 148 start-page: 296 year: 2007 ident: ref_48 article-title: The loss of immunodominant epitopes affects interferon-gamma production and lytic activity of the human influenza virus-specific cytotoxic T lymphocyte response in vitro publication-title: Clin. Exp. Immunol. doi: 10.1111/j.1365-2249.2007.03340.x contributor: fullname: Berkhoff – volume: 31 start-page: 49 year: 2012 ident: ref_4 article-title: Seasonal influenza vaccine efficacy and its determinants in children and non-elderly adults: A systematic review with meta-analyses of controlled trials publication-title: Vaccine doi: 10.1016/j.vaccine.2012.10.084 contributor: fullname: DiazGranados – ident: ref_31 – volume: 217 start-page: 731 year: 2018 ident: ref_6 article-title: Duration of Influenza Vaccine Effectiveness: A Systematic Review, Meta-analysis, and Meta-regression of Test-Negative Design Case-Control Studies publication-title: J. Infect. Dis. doi: 10.1093/infdis/jix632 contributor: fullname: Young – ident: ref_52 – volume: 12 start-page: 9 year: 2006 ident: ref_58 article-title: Influenza pandemics of the 20th century publication-title: Emerg. Infect. Dis. doi: 10.3201/eid1201.051254 contributor: fullname: Kilbourne – volume: 96 start-page: e6339 year: 2017 ident: ref_14 article-title: Evaluating the immuno-genicity and safety of a BiondVax-developed universal influenza vaccine (Multimeric-001) either as a standalone vaccine or as a primer to H5N1 influenza vaccine: Phase IIb study protocol publication-title: Medicine doi: 10.1097/MD.0000000000006339 contributor: fullname: Liu – volume: 80 start-page: 840 year: 1983 ident: ref_40 article-title: Localization, synthesis, and activity of an antigenic site on influenza virus hemagglutinin publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.80.3.840 contributor: fullname: Atassi – ident: ref_8 doi: 10.3390/v12101186 – volume: 16 start-page: 2001 year: 2018 ident: ref_37 article-title: H1N1 influenza virus epitopes classified by monoclonal antibodies publication-title: Exp. Ther. Med. contributor: fullname: Guo – volume: 48 start-page: 783 year: 2020 ident: ref_24 article-title: Allele frequency net database (AFND) 2020 update: Gold-standard data classification, open access genotype data and new query tools publication-title: Nucleic Acid Res. contributor: fullname: McCabe – volume: 82 start-page: 9283 year: 2008 ident: ref_50 article-title: Influenza A virus matrix protein 1-specific human CD8+ T-cell response induced in trivalent inactivated vaccine recipients publication-title: J. Virol. doi: 10.1128/JVI.01047-08 contributor: fullname: Terajima – volume: 119 start-page: 1 year: 2006 ident: ref_35 article-title: Variation and infectivity neutralization in influenza publication-title: Immunology doi: 10.1111/j.1365-2567.2006.02421.x contributor: fullname: Knossow – volume: 171 start-page: 3163 year: 2003 ident: ref_46 article-title: HLA class II-restricted CD4+ T cell responses directed against influenza viral antigens postinfluenza vaccination publication-title: J. Immunol. doi: 10.4049/jimmunol.171.6.3163 contributor: fullname: Danke – volume: 20 start-page: 1160 year: 2019 ident: ref_17 article-title: MAFFT online service: Multiple sequence alignment, interactive sequence choice and visualization publication-title: Brief. Bioinform. doi: 10.1093/bib/bbx108 contributor: fullname: Katoh – volume: 108 start-page: 9178 year: 2011 ident: ref_10 article-title: Systematic identification of immunodominant CD8+ T-cell responses to influenza A virus in HLA-A2 individuals publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1105624108 contributor: fullname: Wu – volume: 154 start-page: 703 year: 1995 ident: ref_51 article-title: HLA-A*0201 complexes with two 10-Mer peptides differing at the P2 anchor residue have distinct refolding kinetics publication-title: J. Immunol. doi: 10.4049/jimmunol.154.2.703 contributor: fullname: Robbins – volume: 79 start-page: 7380 year: 2005 ident: ref_43 article-title: Universal influenza B vaccine based on the maturational cleavage site of the hemagglutinin precursor publication-title: J. Virol. doi: 10.1128/JVI.79.12.7380-7388.2005 contributor: fullname: Bianchi – ident: ref_30 – volume: 10 start-page: 690 year: 2015 ident: ref_3 article-title: Emerging influenza viruses and the prospect of a universal influenza virus vaccine publication-title: Biotechnol. J. doi: 10.1002/biot.201400393 contributor: fullname: Krammer – ident: ref_38 doi: 10.1186/s12864-019-6311-z – volume: 19 start-page: 239 year: 2020 ident: ref_7 article-title: Next-generation influenza vaccines: Opportunities and challenges publication-title: Nat. Rev. Drug Discov. doi: 10.1038/s41573-019-0056-x contributor: fullname: Wei – ident: ref_29 doi: 10.1371/journal.pone.0155340 – volume: 213 start-page: 738 year: 2016 ident: ref_57 article-title: Global Mortality Impact of the 1957–1959 Influenza Pandemic publication-title: J. Infect. Dis. doi: 10.1093/infdis/jiv534 contributor: fullname: Viboud – volume: 890 start-page: 59 year: 2012 ident: ref_25 article-title: Easy and efficient protocols for working with recombinant vaccinia virus MVA publication-title: Vaccinia Virus and Poxvirology doi: 10.1007/978-1-61779-876-4_4 contributor: fullname: Kremer – volume: 34 start-page: 5845 year: 2016 ident: ref_9 article-title: Influenza Vaccine Research funded by the European Commission FP7-Health-2013-Innovation-1 project publication-title: Vaccine doi: 10.1016/j.vaccine.2016.10.040 contributor: fullname: Liu – volume: 50 start-page: 61 year: 1996 ident: ref_44 article-title: Binding of ALA-substituted analogs of HA306-320 to DR1101, DR1301, and DR0402 molecules: Correlation of DR-peptide interactions with recognition by a single TCR publication-title: Hum. Immunol. doi: 10.1016/0198-8859(96)00117-6 contributor: fullname: Zeliszewski – volume: 161 start-page: 1599 year: 1998 ident: ref_36 article-title: Antigen processing of two H2-IEd-restricted epitopes is differentially influenced by the structural changes in a viral glycoprotein publication-title: J. Immunol. doi: 10.4049/jimmunol.161.4.1599 contributor: fullname: Russell – volume: 42 start-page: 19.11.1 year: 2001 ident: ref_33 article-title: Influenza virus publication-title: Curr. Protoc. Immunol. doi: 10.1002/0471142735.im1911s42 contributor: fullname: Cottey – volume: 13 start-page: 539 year: 1984 ident: ref_41 article-title: A novel approach for localization of the continuous protein antigenic sites by comprehensive synthetic surface scanning: Antibody and T-cell activity to several influenza hemagglutinin synthetic sites publication-title: Immunol. Commun. doi: 10.3109/08820138409061305 contributor: fullname: Atassi – ident: ref_54 – volume: 38 start-page: 2527 year: 2020 ident: ref_56 article-title: Comparison of influenza-specific neutralizing antibody titers determined using different assay readouts and hemagglutination inhibition titers: Good correlation but poor agreement publication-title: Vaccine doi: 10.1016/j.vaccine.2020.01.088 contributor: fullname: Sicca – volume: 27 start-page: 493 year: 1938 ident: ref_26 article-title: A simple method of estimating fifty per cent endpoints publication-title: Am. J. Epidemiol. doi: 10.1093/oxfordjournals.aje.a118408 contributor: fullname: Reed – volume: 12 start-page: 66 year: 2006 ident: ref_59 article-title: Vaccines for pandemic influenza publication-title: Emerg. Infect. Dis. doi: 10.3201/eid1201.051147 contributor: fullname: Luke – volume: 52 start-page: 1 year: 2011 ident: ref_12 article-title: Potent CD8+ T-cell immunogenicity in humans of a novel heterosubtypic influenza A vaccine, MVA-NP+M1 publication-title: Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am. doi: 10.1093/cid/ciq015 contributor: fullname: Berthoud – volume: 25 start-page: 1189 year: 2009 ident: ref_18 article-title: Jalview Version 2—A multiple sequence alignment editor and analysis workbench publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp033 contributor: fullname: Waterhouse – volume: 12 start-page: 144100843 year: 2014 ident: ref_21 article-title: Co-evolution analysis to predict protein-protein interactions within in-fluenza virus envelope publication-title: J. Bioinform. Comput. Biol. doi: 10.1142/S021972001441008X contributor: fullname: Mintaev – ident: ref_15 – ident: ref_19 – volume: 32 start-page: 5816 year: 2014 ident: ref_53 article-title: Priming by a novel universal influenza vaccine (Multimeric-001)-a gateway for improving immune response in the elderly population publication-title: Vaccine doi: 10.1016/j.vaccine.2014.08.031 contributor: fullname: Atsmon – ident: ref_22 – volume: 289 start-page: 114056 year: 2021 ident: ref_27 article-title: Application of real-time PCR to significantly reduce the time to obtain recombinant MVA virus publication-title: J. Virol. Methods doi: 10.1016/j.jviromet.2020.114056 contributor: fullname: Orlova – volume: 1161 start-page: 24 year: 2014 ident: ref_34 article-title: Serum virus neutralization assay for detection and quantitation of serum-neutralizing antibodies to influenza A virus in swine publication-title: Methods in Molecular Biology contributor: fullname: Spackman – volume: 11 start-page: 297 year: 1991 ident: ref_20 article-title: Information-Theoretical Entropy as a Measure of Sequence Variability publication-title: Proteins Struct. Funct. Bioinform. doi: 10.1002/prot.340110408 contributor: fullname: Shenkin |
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| Snippet | Vaccination is an effective and economically viable means of protection against the influenza virus, but due to rapid viral evolution, modern seasonal vaccines... |
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| SubjectTerms | Algorithms Antigens Cell culture Clinical trials Epidemics epitope Epitopes Immunization Influenza Influenza A Kinases MVA Pandemics Plasmids Proteins Strains (organisms) universal vaccine Vaccines Vaccinia Viruses |
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| Title | Development of a Universal Epitope-Based Influenza Vaccine and Evaluation of Its Effectiveness in Mice |
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