TAK1 Is Required for Survival of Mouse Fibroblasts Treated with TRAIL, and Does So by NF-κB Dependent Induction of cFLIPL

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is known as a “death ligand”—a member of the TNF superfamily that binds to receptors bearing death domains. As well as causing apoptosis of certain types of tumor cells, TRAIL can activate both NF-κB and JNK signalling pathways. T...

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Bibliographic Details
Published in:	PloS one Vol. 5; no. 1; p. e8620
Main Authors:	Lluis, Josep Maria, Nachbur, Ulrich, Cook, Wendy Diane, Gentle, Ian Edward, Moujalled, Donia, Moulin, Maryline, Wong, Wendy Wei-Lynn, Khan, Nufail, Chau, Diep, Callus, Bernard Andrew, Vince, James Edward, Silke, John, Vaux, David Lawrence
Format:	Journal Article
Language:	English
Published:	San Francisco Public Library of Science 08-01-2010
Subjects:	Activation Apoptosis Biochemistry Biochemistry/Cell Signaling and Trafficking Structures Cell Biology/Cell Signaling Cell Biology/Cellular Death and Stress Responses Cell death Cloning Colorectal cancer Cytokines Ectopic expression Embryo fibroblasts Embryos Ethics Fibroblasts IKK2 protein JNK protein Kinases Leukemia Ligands Mortality NF-κB protein Prostate cancer Proteins Receptors Signal transduction Signaling Survival TAK1 protein TRAIL protein Tumor cells Tumor necrosis factor Tumor necrosis factor-TNF
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