ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress

Intracellular proteinaceous inclusions are well-documented hallmarks of the fatal motor neuron disorder amyotrophic lateral sclerosis (ALS). The pathological significance of these inclusions remains unknown. Peripherin, a type III intermediate filament protein, is upregulated in ALS and identified a...

Full description

Saved in:

Bibliographic Details
Published in:	Experimental neurology Vol. 261; pp. 217 - 229
Main Authors:	McLean, Jesse R., Smith, Gaynor A., Rocha, Emily M., Osborn, Teresia M., Dib, Samar, Hayes, Melissa A., Beagan, Jonathan A., Brown, Tana B., Lawson, Tristan F.S., Hallett, Penelope J., Robertson, Janice, Isacson, Ole
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-11-2014
Subjects:	Aggregation Amyotrophic lateral sclerosis (ALS) Carcinoma - pathology Cell Line, Tumor DNA-Binding Proteins - metabolism Dose-Response Relationship, Drug Humans Hydrogen Peroxide - pharmacology Inclusion Inclusion Bodies - genetics Inclusion Bodies - metabolism Intermediate filament Oxidative Stress - drug effects Oxidative Stress - genetics Peripherin Peripherins - genetics Peripherins - metabolism Protein Aggregation, Pathological - genetics Protein Isoforms - genetics Protein Isoforms - metabolism Proto-Oncogene Proteins c-myc - metabolism RNA, Messenger - metabolism Splicing Stress TDP-43 Time Factors Transfection Ubiquitin - metabolism Vimentin - metabolism Aggregation Inclusion Splicing Amyotrophic lateral sclerosis (ALS) TDP-43 Peripherin Intermediate filament Stress
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!