Synthesis and properties of 6-alkynyl-5-aryluracils

The development of a new and straightforward chemoselective method for the synthesis of uracil-based structures by combining Suzuki-Miyaura and Sonogashira-Hagihara cross-coupling is reported. The methodology was applied to synthesize a series of novel compounds. The tolerance of the combination of...

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Bibliographic Details
Published in:	Beilstein journal of organic chemistry Vol. 20; no. 1; pp. 898 - 911
Main Authors:	de Abreu, Ruben Manuel Figueira, Brockmann, Till, Villinger, Alexander, Ehlers, Peter, Langer, Peter
Format:	Journal Article
Language:	English
Published:	Germany Beilstein-Institut 22-04-2024
Subjects:	catalysis Chemistry cross-coupling fluorescence Full Research Paper heterocycles regioselectivity regioselectivity cross-coupling catalysis fluorescence heterocycles
Online Access:	Get full text
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Summary:	The development of a new and straightforward chemoselective method for the synthesis of uracil-based structures by combining Suzuki-Miyaura and Sonogashira-Hagihara cross-coupling is reported. The methodology was applied to synthesize a series of novel compounds. The tolerance of the combination of different functional groups was tested. The influence of different functional groups on the physical properties was studied by ultraviolet-visible (UV-vis) and fluorescence spectroscopy, providing new insights into the potential applications of uracil-based structures.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Tel.: +49 381 498 6410, Fax: +49 381 498 6412
ISSN:	1860-5397 1860-5397
DOI:	10.3762/bjoc.20.80