M-TAP Dance: Targeting PRMT1 and PRMT5 Family Members to Push Cancer Cells Over the Edge

• Published in: Cancer cell Vol. 36; no. 1; pp. 3 - 5
• Main Authors: Srour, Nivine, Mersaoui, Sofiane Y., Richard, Stéphane
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 08-07-2019
• Subjects: Dancing; Enzyme Inhibitors; Humans; Methylation; Neoplasms; Protein-Arginine N-Methyltransferases; Repressor Proteins
• ISSN: 1535-6108; 1878-3686
• DOI: 10.1016/j.ccell.2019.06.004

In this issue of Cancer Cell, Fedoriw and colleagues characterize a potent reversible inhibitor of type I PRMTs, GSK3368715, with anti-proliferative effects on numerous cancer types. Using a combination of GSK3368715 with PRMT5 inhibitors, the authors show that a threshold of overall arginine methylation reduction needs to be achieved for synergistic anti-tumor activity.
In this issue of Cancer Cell, Fedoriw and colleagues characterize a potent reversible inhibitor of type I PRMTs, GSK3368715, with anti-proliferative effects on numerous cancer types. Using a combination of GSK3368715 with PRMT5 inhibitors, the authors show that a threshold of overall arginine methylation reduction needs to be achieved for synergistic anti-tumor activity.