Antimicrobial indolequinones from the mid-intestinal gland of the muricid gastropod Drupella fragum
Three new indolequinones, 6-methoxyindole-4,7-quinone ( 1), 5-methoxyindole-4,7-quinone ( 2) and 5-methylindole-4,7-quinone ( 3) were isolated from the mid-intestinal gland of the muricid gastropod Drupella fragum. The structures of 1 and 2 were established by spectroscopic methods and total synthes...
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Published in: | Tetrahedron Vol. 54; no. 34; pp. 10007 - 10016 |
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Main Authors: | , , , , , |
Format: | Journal Article |
Language: | English |
Published: |
Elsevier Ltd
01-08-1998
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Subjects: | |
Online Access: | Get full text |
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Summary: | Three new indolequinones, 6-methoxyindole-4,7-quinone (
1), 5-methoxyindole-4,7-quinone (
2) and 5-methylindole-4,7-quinone (
3) were isolated from the mid-intestinal gland of the muricid gastropod
Drupella fragum. The structures of
1 and
2 were established by spectroscopic methods and total synthesis, whereas the structure of
3 was elucidated mainly by NMR spectroscopic analyses. Compounds
1 ∼ 3
exhibited moderate antimicrobial activities against
Staphylococcus aureus, Bacillus subtilis, and
Escherichia coli with MIC = 6.25 ∼ 50 μg/mL.
The structures of antimicrobial indolequinones,
1, 2 and
3 isolated from the mid-intestinal gland of the muricid gastropod
Drupella fragum were established by spectroscopic methods and total synthesis. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0040-4020 1464-5416 |
DOI: | 10.1016/S0040-4020(98)00593-6 |