Synthesis, X-ray structure, interactions with DNA, remarkable in vivo tumor growth suppression and nephroprotective activity of cis-tetrachloro-dipivalato dirhenium(III)

In this study we report the synthesis, the X-ray crystal structure and the in vivo tumor growth suppression and nephroprotective activity of bis-dimethylsulfoxide-cis-tetrachlorodi-μ-pivalatodirhenium(III), cis-Re2[(CH3)3CCOO]2Cl4·2(CH3)2SO (I). The interactions of I with DNA were also investigated...

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Bibliographic Details
Published in:	Journal of inorganic biochemistry Vol. 129; pp. 127 - 134
Main Authors:	Shtemenko, Natalia I., Chifotides, Helen T., Domasevitch, Konstantin V., Golichenko, Alexander A., Babiy, Svetlana A., Li, Zhanyong, Paramonova, Katherina V., Shtemenko, Alexander V., Dunbar, Kim R.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-12-2013
Subjects:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cisplatin - chemistry Cisplatin - pharmacology Combination therapy Crystallography, X-Ray Dirhenium DNA cleavage DNA, Neoplasm - chemistry DNA, Neoplasm - metabolism Drug Screening Assays, Antitumor Neoplasms, Experimental - drug therapy Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Oxidation-Reduction Rats Rats, Wistar Rhenium - chemistry Rhenium - pharmacology Tumor suppression DNA cleavage Tumor suppression Combination therapy Dirhenium
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