Placental Growth Factor (PlGF) Is a Surrogate Marker in Preeclamptic Hypertension

• Published in: Hypertension in pregnancy Vol. 27; no. 1; pp. 65 - 73
• Main Authors: Teixeira, Patrícia Gonçalves, Cabral, Antônio Carlos Vieira, Andrade, Silvia Passos, Reis, Zilma Silveira Nogueira, da Cruz, Lívia Pieroni Barroso, Pereira, Jacqueline Braga, de Barcelos Martins, Breno Oliveira, de Lima Rezende, Cezar Alencar
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01-01-2008; Taylor & Francis
• Subjects: Adult; Angiogenic factors; Biomarkers; Brazil; Brazilian women; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hypertension; Hypertension - blood; Hypertension - diagnosis; Placenta Growth Factor; Pre-Eclampsia - blood; Pre-Eclampsia - diagnosis; Pregnancy; Pregnancy Proteins - blood; Vascular Endothelial Growth Factor A - blood
• ISSN: 1064-1955; 1525-6065
• DOI: 10.1080/10641950701825937

Objective: To evaluate plasma levels of angiogenic factors and their association with preeclampsia. Methods: Twenty-three women with preeclampsia and nine normotensive pregnant women from the Maternity of Hospital das Clínicas of Belo Horizonte MG-Brazil were assessed by National High Blood Pressure Education Program Working Group Creteria (NHBPEPWG). The plasma levels of vascular endothelial growth factor (VEGF) and Placental growth factor (PlGF) were determined by ELISA assay. Results: Plasma concentration of PlGF was 12-fold lower in preeclampsia versus non preeclampsia pregnancies. An inverse correlation was observed between PlGF plasma levels and mean arterial pressure (MAP); a decrease in 1pg mL of PlGF resulted in 6.18 mm Hg increase in MAP. Conclusion: These results indicate that PlGF is related to MAP in pregnant women.