Human arginase 1, a Jack of all trades?

Arginine, a conditionally essential amino acid, plays a crucial role in several metabolic and signalling pathways. Arginine metabolism in the body can be significantly increased under stress or during certain pathological conditions. Depletion of circulating arginine by administering arginine-hydrol...

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Bibliographic Details
Published in:	3 Biotech Vol. 12; no. 10; p. 264
Main Authors:	Anakha, J., Kawathe, Priyanka S., Datta, Sayantap, Jawalekar, Snehal Sainath, Banerjee, Uttam Chand, Pande, Abhay H.
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01-10-2022 Springer Nature B.V
Subjects:	Agriculture Amino acids Arginase Arginine Bioinformatics Biomaterials Biotechnology Cancer Research Chemistry Chemistry and Materials Science Depletion Inflammation Microorganisms Review Review Article Signal transduction Stem Cells Arginase Auxotrophy PEGylation Arginine Fusion protein
Online Access:	Get full text
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Summary:	Arginine, a conditionally essential amino acid, plays a crucial role in several metabolic and signalling pathways. Arginine metabolism in the body can be significantly increased under stress or during certain pathological conditions. Depletion of circulating arginine by administering arginine-hydrolysing enzyme has been shown to mitigate varied pathophysiological conditions ranging from cancer, inflammatory conditions, and microbial infection. This review provides an overview of such intriguing expanse of potential applications of recombinant human arginase 1 for different pathological conditions and its status of development.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	2190-572X 2190-5738
DOI:	10.1007/s13205-022-03326-9