Genetic relationships and inbreeding levels among geographically distant populations of Felis catus from Japan and the United States

• Published in: Genomics (San Diego, Calif.) Vol. 113; no. 1; pp. 104 - 110
• Main Authors: Matsumoto, Yuki, Ruamrungsri, Napat, Arahori, Minori, Ukawa, Hisashi, Ohashi, Ken, Lyons, Leslie A., Ishihara, Genki
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-01-2021
• Subjects: Animals; Cats - classification; Cats - genetics; Diversity of populations; Felis catus; Inbreeding; Inbreeding Depression; Japan; Phylogeny; Polymorphism, Genetic; Reproductive Isolation; Runs of homozygosity; Single-nucleotide polymorphism; United States; United States; Japan; Runs of homozygosity; Diversity of populations; FROH; MJR; SNP; FST; Ne; Inbreeding; Single-nucleotide polymorphism; Felis catus
• ISSN: 0888-7543; 1089-8646
• DOI: 10.1016/j.ygeno.2020.11.018

Pedigreed cats have traditionally been mated with close relatives, which increases the risks for inbreeding depression and genetic disorders. We evaluated the genome-wide population structure and the degree of inbreeding of 1022 cats, including 13 pedigreed and two random bred populations from Japan and the USA, using single nucleotide polymorphism array-based data. Ancestry structure analysis revealed Japan's American Curl, Norwegian Forest, and Siamese cat populations were genetically distinct from their American counterparts. Furthermore, we found an ancestral genetic component shared between five pedigreed and random bred Japanese cats, suggesting the breeds were admixed with Japanese cats or cats of east Asian origin. Between-country differences in inbreeding estimates based on runs of homozygosity were found for Maine Coon, Siamese, and random bred cats. To reduce the risks of inbreeding depression and genetic disorders, particularly for highly inbred breeds, such as Abyssinian cats, as well as Russian Blue and Siamese cats in the USA, appropriate breeding practices must be observed, including mating practices that increase the genetic diversity.
•We evaluated the genetic structure of pedigreed and random-bred cat populations.•Some Japanese breeds were genetically distinct from their American counterparts.•Certain pedigreed breeds were admixed with cats of Japanese or East Asian origin.•We highlight the risks of inbreeding depression for highly inbred Abyssinians.