Atypical genotoxicity of carcinogenic nickel(II): Linkage to dNTP biosynthesis, DNA-incorporated rNMPs, and impaired repair of TOP1-DNA crosslinks

Cancer is a genetic disease requiring multiple mutations for its development. However, many carcinogens are DNA-unreactive and nonmutagenic and consequently described as nongenotoxic. One of such carcinogens is nickel, a global environmental pollutant abundantly emitted by burning of coal. We invest...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 299; no. 12; p. 105385
Main Authors:	Krawic, Casey, Luczak, Michal W., Valiente, Sophia, Zhitkovich, Anatoly
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-12-2023 American Society for Biochemistry and Molecular Biology
Subjects:	DNA-embedded ribonucleotides DNA-topoisomerase I crosslink nickel replication stress ribonucleotide reductase DNA-embedded ribonucleotides ribonucleotide reductase nickel replication stress DPC RNR FL-RIB assay Ni DNA-topoisomerase I crosslink TYMS RER rNMPs
Online Access:	Get full text
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