Sildenafil inhibits duodenal contractility via activation of the NO-K+ channel pathway

Phosphodiesterase type‐5 (PDE5) specifically cleaves cyclic guanosine monophosphate (cGMP), a key intracellular secondary messenger. The PDE5 inhibitor sildenafil is a well‐known vasodilator that also has gastrointestinal myorelaxant properties. In the present study, we further investigated sildenaf...

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Bibliographic Details
Published in:	Fundamental & clinical pharmacology Vol. 22; no. 1; pp. 61 - 67
Main Authors:	Clemente, Cristiano M., Araújo, Paula V., Palheta Jr, Raimundo C., Ratts, Zoélia M. L., Fernandes, Geórgea H., Rola, Francisco H., De Oliveira, Ricardo B., Dos Santos, Armênio A., Magalhães, Pedro J. C.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-02-2008
Subjects:	Animals Colforsin - pharmacology contractility Diazoxide - pharmacology duodenum Duodenum - drug effects Duodenum - physiology In Vitro Techniques Male Muscle Contraction - drug effects NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide - physiology Nitric Oxide Donors - pharmacology Nitric Oxide Synthase Type II - antagonists & inhibitors Nitric Oxide Synthase Type III Nitroprusside - pharmacology phosphodiesterase Phosphodiesterase Inhibitors - pharmacology Piperazines - pharmacology Potassium Channel Blockers - pharmacology Potassium Channels - physiology Purines - pharmacology rat Rats Rats, Wistar sildenafil Sildenafil Citrate smooth muscle Sulfones - pharmacology Vasodilator Agents - pharmacology
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