Immunoglobulin A dominant membranoproliferative glomerulonephritis in an elderly man: A case report and review of the literature

• Published in: Indian journal of nephrology Vol. 25; no. 3; pp. 168 - 170
• Main Authors: Agrawal, V, Kaul, A, Ranade, R S, Sharma, R K
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01-05-2015; Scientific Scholar; Medknow Publications & Media Pvt Ltd
• Subjects: Biopsy; Care and treatment; Case Report; Case studies; Diagnosis; Elderly; Gangrene; Glomerulonephritis; Health aspects; Histology; Immunoglobulin A; Infections; Kidney diseases; Microscopy; Sediments; Urine; India; Adult nephrotic syndrome; membranoproliferative glomerulonephritis; immunoglobulin A nephropathy; rapidly progressive renal failure
• ISSN: 0971-4065; 1998-3662
• DOI: 10.4103/0971-4065.145425

Immunoglobulin A (IgA) dominant membranoproliferative glomerulonephritis (MPGN) is rare, described only as case reports. We report a rare case of an elderly man presenting with rapidly progressive renal failure and nephrotic range proteinuria with histological, immunofluorescence, and ultrastructural findings supporting a diagnosis of IgA dominant MPGN. Autoimmune disease, cryoglobulinemia and infection-associated glomerulonephritis were excluded. Remission was achieved within 3 months of treatment. This case highlights an uncommon diagnosis with a good response to therapy. The differential diagnosis of IgA nephropathy with MPGN-like pattern is discussed.