Genotypes of carboxypeptidase A1 and gamma‐glutamyltransferase 1 may be useful tools for the diagnosis and the predictor of worrisome features of intraductal papillary mucinous neoplasm in Japan

• Published in: JGH open Vol. 8; no. 10; pp. e70031 - n/a
• Main Authors: Agawa, Shuhei, Futagami, Seiji, Nakamura, Ken, Habiro, Mayu, Kawawa, Rie, Shinagawa, Yuto, Motomiya, Rina, Kirita, Kumiko, Akimoto, Teppei, Onda, Takeshi, Tanabe, Tomohide, Ueki, Nobue, Honda, Kazufumi, Gwee, Kok‐Ann, Iwakiri, Katsuhiko
• Format: Journal Article
• Language: English
• Published: Melbourne Wiley Publishing Asia Pty Ltd 01-10-2024; John Wiley & Sons, Inc; Wiley
• Subjects: Alcohol; Apolipoproteins; Body mass index; carboxypeptidase A1; Cysts; Disease; endosonography; gamma‐glutamyltransferase 1; Gender; Genotype & phenotype; Hospitals; intraductal papillary mucinous neoplasm; Original; Pancreatic cancer; Pancreatitis; single‐nucleotide polymorphism; Tumors; Variance analysis; United States > US; Japan; gamma‐glutamyltransferase 1; single‐nucleotide polymorphism; intraductal papillary mucinous neoplasm; carboxypeptidase A1; endosonography
• ISSN: 2397-9070; 2397-9070
• DOI: 10.1002/jgh3.70031

Background and Aim
This study aimed to clarify whether several single‐nucleotide polymorphisms (SNPs)‐related chronic pancreatitis such as carboxypeptidase A1 (CPA1), carboxypeptidase B1 (CPB1), Gamma‐glutamyltransferase 1 (GGT1), G‐protein‐coupled receptor Class C Group 6 Member A (GPRC6A), and serine protease inhibitor, Kazal type 1 (SPINK‐1) genotypes were associated with clinical characteristics of patients with intraductal papillary mucinous neoplasm (IPMN) and worrisome features of IPMN.
Methods
We enrolled 100 patients with IPMN and 116 patients as a control. Serum p‐amylase, lipase, trypsin, phospholipase A2 (PLA2), and elastase‐1 levels were measured. An Olympus EUS (GF‐UCT 260) was used to perform endosonography in 100 patients with IPMN. Total EUS score was evaluated using endosonography. DNA was isolated from the duodenal tissue using a commercial system and polymerase chain reaction (PCR) was performed on 7500 Fast PCR System.
Results
There were no associations between glucose tolerances, lipid levels and genotypes of CPA1, GGT1, GPRC6A, and SPINK‐1 in patients with IPMN. CPA1 genotype was significantly associated with the pathophysiology of IPMN. Then, GGT1 genotype was also significantly associated with EUS total score and the size of cyst more than 20 mm and more than 30 mm as one of worrisome features of IPMN.
Conclusion
Genotypes of carboxypeptidase A1 and gamma‐glutamyltransferase 1 may be useful tools for the diagnosis and the predictor of worrisome features of IPMN.
CPA1 and GGT1, a type of SNP, may be associated with intraductal papillary mucinous neoplasm (IPMN). In this study, CPA1 and GGT1 were associated with the presence of IPMN and cyst size, respectively. It may be useful tools for the diagnosis and the predictor of worrisome features of intraductal papillary mucinous neoplasm in Japan.