A novel invasive Streptococcus pyogenes variant sublineage derived through recombinational replacement of the emm12 genomic region

Group A streptococcal strains potentially acquire new M protein gene types through genetic recombination ( emm switching). To detect such variants, we screened 12,596 invasive GAS genomes for strains of differing emm types that shared the same multilocus sequence type (ST). Through this screening we...

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Bibliographic Details
Published in:	Scientific reports Vol. 13; no. 1; pp. 21510 - 15
Main Authors:	Unoarumhi, Yvette, Davis, Morgan L., Rowe, Lori A., Mathis, Saundra, Li, Zhongya, Chochua, Sopio, Li, Yuan, McGee, Lesley, Metcalf, Benjamin J., Lee, Justin S., Beall, Bernard
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 06-12-2023 Nature Publishing Group Nature Portfolio
Subjects:	631/326 631/337 Anti-Bacterial Agents - pharmacology Antibiotic resistance Antigens, Bacterial - genetics Antimicrobial agents Bacterial Outer Membrane Proteins - genetics Cardiovascular disease Disease control Drug Resistance, Bacterial - genetics Genes Genomes Genomics Genotype Humanities and Social Sciences Humans Impetigo Infections M protein multidisciplinary Opacity Pediatrics Phenotypes Phylogenetics Phylogeny Proteins Respiratory diseases Science Science (multidisciplinary) Serum opacity factor Single-nucleotide polymorphism Streptococcal Infections - drug therapy Streptococcus infections Streptococcus pyogenes Vaccines Virulence
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