Performance of Vibration-Controlled Transient Elastography and Clinical Prediction Models In Liver Transplant Recipients

• Published in: Clinical gastroenterology and hepatology Vol. 21; no. 4; pp. 1100 - 1102.e2
• Main Authors: Siddiqui, Mohammad Shadab, Bui, Anh T., Syed, Taseen, Tseng, Michael, Hassouneh, Ramzi, Bhati, Chandra S., Ng, Cheng Han, Arshad, Tamoore, Miller, Austin, Flynn, Sean, Patel, Vaishali, Asgharpour, Amon, Patel, Sohum, Idowu, Michael O., Muthiah, Mark
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-04-2023
• Subjects: Adult; Aged; Clinical Decision Rules; Elasticity Imaging Techniques; Female; Humans; Liver - pathology; Liver Cirrhosis - diagnostic imaging; Liver Cirrhosis - pathology; Liver Transplantation; Male; Middle Aged; Models, Statistical; Transplant Recipients; Vibration
• ISSN: 1542-3565; 1542-7714
• DOI: 10.1016/j.cgh.2022.02.023

Hepatic fibrosis is a strong predictor of clinical outcomes following liver transplantation (LT).1 Despite the centrality of hepatic fibrosis in clinical outcomes, the published literature with noninvasive fibrosis assessment in LT recipients is limited and liver biopsy, despite its invasive nature, remains the reference standard. Vibration-controlled transient elastography (VCTE) and clinical prediction models (CPM) are point-of-care tests that can provide noninvasive assessment of hepatic fibrosis2–4; however, the data comparing the diagnostic performance of VCTE and CPM in LT recipients are lacking. The current study evaluated the diagnostic performance of VCTE and CPM in LT recipients using best practices in regulatory sciences for biomarker development.