Modulation of Inflammatory Processes by Leaves Extract from Clusia nemorosa Both In Vitro and In Vivo Animal Models

The present study was carried out to investigate the anti-inflammatory effect of the hexane extract of the leaves from Clusia nemorosa G. Mey, called HECn, using carrageenan-induced mice pleurisy and cotton pellet-induced mice granuloma. Additionally, the ability of HECn to affect both neutrophil mi...

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Published in:	Inflammation Vol. 35; no. 2; pp. 764 - 771
Main Authors:	Farias, José Alex C., Ferro, Jamylle Nunes S., Silva, Juliane P., Agra, Isabela Karine R., Oliveira, Fernando M., Candea, André Luiz P., Conte, Fernando P., Ferraris, Fausto K., Henriques, Maria das Graças M. O., Conserva, Lucia M., Barreto, Emiliano
Format:	Journal Article
Language:	English
Published:	Boston Springer US 01-04-2012 Springer Nature B.V
Subjects:	Animals Anti-Inflammatory Agents - pharmacology Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Carrageenan Cells, Cultured Chemotaxis, Leukocyte - drug effects Clusia Cotton Fiber Granuloma - chemically induced Granuloma - drug therapy Granuloma - immunology Humans Immunology Internal Medicine Mice Neutrophils - immunology Neutrophils - physiology Pathology Pharmacology/Toxicology Phytotherapy Plant Extracts - pharmacology Plant Leaves Pleurisy - chemically induced Pleurisy - drug therapy Pleurisy - immunology Rheumatology Tumor Necrosis Factor-alpha - biosynthesis anti-inflammatory effect neutrophil pleurisy chemotaxis
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Abstract	The present study was carried out to investigate the anti-inflammatory effect of the hexane extract of the leaves from Clusia nemorosa G. Mey, called HECn, using carrageenan-induced mice pleurisy and cotton pellet-induced mice granuloma. Additionally, the ability of HECn to affect both neutrophil migration as viability was investigated by use of the Boyden chamber assay and flow cytometry, respectively. The HECn significantly inhibited exudation, total leukocytes and neutrophils influx, as well as TNFα levels in carrageenan-induced pleurisy. However, the extract not suppressed the granulomatous tissue formation in the cotton pellet-induced granuloma test. Experiments performed in vitro revealed that HECn on human neutrophils inhibited a dose-dependent manner the CXCL1-induced neutrophil chemotaxis. Furthermore, HECn also inhibited the chemoattraction of human neutrophils induced by formyl-methionyl-leucyl-phenylalanine (fMLP), leukotriene B4 (LTB4) and platelet activating factor (PAF) in a Boyden chamber. However, this same treatment not was able to induce apoptosis. The results obtained in this study showed that the extract from leaves of C. nemorosa possess a potent inhibitory activity in acute model of inflammation, being the effects mediated, in part, by inhibition of neutrophil responsiveness. These results indicate that C. nemorosa could be a good source for anti-inflammatory compounds.
AbstractList	The present study was carried out to investigate the anti-inflammatory effect of the hexane extract of the leaves from Clusia nemorosa G. Mey, called HECn, using carrageenan-induced mice pleurisy and cotton pellet-induced mice granuloma. Additionally, the ability of HECn to affect both neutrophil migration as viability was investigated by use of the Boyden chamber assay and flow cytometry, respectively. The HECn significantly inhibited exudation, total leukocytes and neutrophils influx, as well as TNF alpha levels in carrageenan-induced pleurisy. However, the extract not suppressed the granulomatous tissue formation in the cotton pellet-induced granuloma test. Experiments performed in vitro revealed that HECn on human neutrophils inhibited a dose-dependent manner the CXCL1-induced neutrophil chemotaxis. Furthermore, HECn also inhibited the chemoattraction of human neutrophils induced by formyl-methionyl-leucyl-phenylalanine (fMLP), leukotriene B4 (LTB4) and platelet activating factor (PAF) in a Boyden chamber. However, this same treatment not was able to induce apoptosis. The results obtained in this study showed that the extract from leaves of C. nemorosa possess a potent inhibitory activity in acute model of inflammation, being the effects mediated, in part, by inhibition of neutrophil responsiveness. These results indicate that C. nemorosa could be a good source for anti-inflammatory compounds. The present study was carried out to investigate the anti-inflammatory effect of the hexane extract of the leaves from Clusia nemorosa G. Mey, called HECn, using carrageenan-induced mice pleurisy and cotton pellet-induced mice granuloma. Additionally, the ability of HECn to affect both neutrophil migration as viability was investigated by use of the Boyden chamber assay and flow cytometry, respectively. The HECn significantly inhibited exudation, total leukocytes and neutrophils influx, as well as TNFα levels in carrageenan-induced pleurisy. However, the extract not suppressed the granulomatous tissue formation in the cotton pellet-induced granuloma test. Experiments performed in vitro revealed that HECn on human neutrophils inhibited a dose-dependent manner the CXCL1-induced neutrophil chemotaxis. Furthermore, HECn also inhibited the chemoattraction of human neutrophils induced by formyl-methionyl-leucyl-phenylalanine (fMLP), leukotriene B4 (LTB4) and platelet activating factor (PAF) in a Boyden chamber. However, this same treatment not was able to induce apoptosis. The results obtained in this study showed that the extract from leaves of C. nemorosa possess a potent inhibitory activity in acute model of inflammation, being the effects mediated, in part, by inhibition of neutrophil responsiveness. These results indicate that C. nemorosa could be a good source for anti-inflammatory compounds. The present study was carried out to investigate the anti-inflammatory effect of the hexane extract of the leaves from Clusia nemorosa G. Mey, called HECn, using carrageenan-induced mice pleurisy and cotton pellet-induced mice granuloma. Additionally, the ability of HECn to affect both neutrophil migration as viability was investigated by use of the Boyden chamber assay and flow cytometry, respectively. The HECn significantly inhibited exudation, total leukocytes and neutrophils influx, as well as TNFα levels in carrageenan-induced pleurisy. However, the extract not suppressed the granulomatous tissue formation in the cotton pellet-induced granuloma test. Experiments performed in vitro revealed that HECn on human neutrophils inhibited a dose-dependent manner the CXCL1-induced neutrophil chemotaxis. Furthermore, HECn also inhibited the chemoattraction of human neutrophils induced by formyl-methionyl-leucyl-phenylalanine (fMLP), leukotriene B4 (LTB4) and platelet activating factor (PAF) in a Boyden chamber. However, this same treatment not was able to induce apoptosis. The results obtained in this study showed that the extract from leaves of C. nemorosa possess a potent inhibitory activity in acute model of inflammation, being the effects mediated, in part, by inhibition of neutrophil responsiveness. These results indicate that C. nemorosa could be a good source for anti-inflammatory compounds. The present study was carried out to investigate the anti-inflammatory effect of the hexane extract of the leaves from Clusia nemorosa G. Mey, called HECn, using carrageenan-induced mice pleurisy and cotton pellet-induced mice granuloma. Additionally, the ability of HECn to affect both neutrophil migration as viability was investigated by use of the Boyden chamber assay and flow cytometry, respectively. The HECn significantly inhibited exudation, total leukocytes and neutrophils influx, as well as TNFα levels in carrageenan-induced pleurisy. However, the extract not suppressed the granulomatous tissue formation in the cotton pellet-induced granuloma test. Experiments performed in vitro revealed that HECn on human neutrophils inhibited a dose-dependent manner the CXCL1-induced neutrophil chemotaxis. Furthermore, HECn also inhibited the chemoattraction of human neutrophils induced by formyl-methionyl-leucyl-phenylalanine (fMLP), leukotriene B4 (LTB4) and platelet activating factor (PAF) in a Boyden chamber. However, this same treatment not was able to induce apoptosis. The results obtained in this study showed that the extract from leaves of C. nemorosa possess a potent inhibitory activity in acute model of inflammation, being the effects mediated, in part, by inhibition of neutrophil responsiveness. These results indicate that C. nemorosa could be a good source for anti-inflammatory compounds.[PUBLICATION ABSTRACT]
Author	Ferraris, Fausto K. Barreto, Emiliano Oliveira, Fernando M. Ferro, Jamylle Nunes S. Candea, André Luiz P. Conserva, Lucia M. Conte, Fernando P. Silva, Juliane P. Henriques, Maria das Graças M. O. Agra, Isabela Karine R. Farias, José Alex C.
Author_xml	– sequence: 1 givenname: José Alex C. surname: Farias fullname: Farias, José Alex C. organization: Laboratório de Biologia Celular, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas – sequence: 2 givenname: Jamylle Nunes S. surname: Ferro fullname: Ferro, Jamylle Nunes S. organization: Laboratório de Biologia Celular, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas – sequence: 3 givenname: Juliane P. surname: Silva fullname: Silva, Juliane P. organization: Laboratório de Biologia Celular, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas – sequence: 4 givenname: Isabela Karine R. surname: Agra fullname: Agra, Isabela Karine R. organization: Laboratório de Biologia Celular, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas – sequence: 5 givenname: Fernando M. surname: Oliveira fullname: Oliveira, Fernando M. organization: Laboratório de Pesquisa em Química dos Produtos Naturais, Instituto de Química e Biotecnologia, Universidade Federal de Alagoas – sequence: 6 givenname: André Luiz P. surname: Candea fullname: Candea, André Luiz P. organization: Laboratório de Farmacologia Aplicada, Farmanguinhos-Fiocruz – sequence: 7 givenname: Fernando P. surname: Conte fullname: Conte, Fernando P. organization: Laboratório de Farmacologia Aplicada, Farmanguinhos-Fiocruz – sequence: 8 givenname: Fausto K. surname: Ferraris fullname: Ferraris, Fausto K. organization: Laboratório de Farmacologia Aplicada, Farmanguinhos-Fiocruz – sequence: 9 givenname: Maria das Graças M. O. surname: Henriques fullname: Henriques, Maria das Graças M. O. organization: Laboratório de Farmacologia Aplicada, Farmanguinhos-Fiocruz – sequence: 10 givenname: Lucia M. surname: Conserva fullname: Conserva, Lucia M. organization: Laboratório de Pesquisa em Química dos Produtos Naturais, Instituto de Química e Biotecnologia, Universidade Federal de Alagoas – sequence: 11 givenname: Emiliano surname: Barreto fullname: Barreto, Emiliano email: emilianobarreto@optma.org organization: Laboratório de Biologia Celular, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Universidade Federal de Alagoas
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References	Lunardelli, Leite, Pires, Oliveira (CR20) 2006; 55 Frode-Saleh, Calixto (CR4) 2000; 49 De Andrade, Almeida, Conserva (CR15) 1998; 47 Teixeira, Moreira, Guedes, Cruz (CR5) 2006; 17 Suffredini, Paciencia, Nepomuceno, Younes, Varella (CR9) 2006; 101 Olajide, Makinde, Awe (CR25) 1999; 66 Hiramatsu, Hatakeyama, Minami, Kumegawa (CR27) 1982; 32 Iinuma, Tosa, Tanaka, Kanamaru, Asai, Kobayashi, Miyauchi, Shimano (CR13) 1996; 19 Huerta-Reyes, Basualdo, Lozada, Jimenez-Estrada, Soler, Reyes-Chilpa (CR8) 2004; 27 Chedier, Paiva, Costa, Figueiredo, Kaplan (CR12) 1999; 22 Swingle, Shideman (CR26) 1972; 183 Zhao, Tao, Zhang, Pang, Jin, Dong, Guo (CR23) 2007; 30 Stauffer (CR16) 1975; 69 Santos, Lunardelli, Caberlon, Bastos, Nunes, Pires, Biolchi, Paul, Vieira, Resende do Carmo Aquino, Corseuil, de Oliveira (CR21) 2010; 33 Gustafson, Blunt, Munro, Fuller, Mckee, Cardellina, Mcmahon, Cragg, Boyd (CR14) 1992; 48 Mikami, Miyasaka (CR3) 1983; 95 Ismail, Gopalakrishnan, Begum, Elango (CR17) 1997; 56 Valeski, Baldwin (CR22) 2000; 89 Peraza-Sánchez, Cen-Pacheco, Noh-Chimal, May-Pat, Simá-Polanco, Dumonteil, García-Miss, Mut-Martín (CR10) 2007; 78 Saklatvala (CR24) 1986; 322 Cerrini, Lamba, Dellemonache, Pinherio (CR11) 1993; 32 Carvalho, Benjamim, Santos, Ferreira, Cunha (CR28) 2005; 525 Zhang, Liu, Wang, Thorlacius (CR2) 2001; 133 Mariz (CR6) 1974; 1 Díaz-Carballo, Seeber, Strumberg, Hilger (CR7) 2003; 41 Vermes, Haanen, Steffens-Nakken, Reutelingsperger (CR19) 1995; 184 Khan, Landis, Rajneesh (CR1) 2003; 27 Coelho, Freitas, Mariano-Oliveira, Oliveira-Carvalho, Zingali, Barja-Fidalgo (CR18) 2001; 9 17482379 - Fitoterapia. 2007 Jun;78(4):315-8 1217730 - Anal Biochem. 1975 Dec;69(2):646-8 7622868 - J Immunol Methods. 1995 Jul 17;184(1):39-51 9174976 - J Ethnopharmacol. 1997 Apr;56(2):145-52 10432217 - J Ethnopharmacol. 1999 Jul;66(1):113-7 17763929 - Inflammation. 2007 Dec;30(6):213-23 11375258 - Br J Pharmacol. 2001 Jun;133(3):413-21 10959554 - Inflamm Res. 2000 Jul;49(7):330-7 6583058 - Eur J Pharmacol. 1983 Nov 11;95(1-2):1-12 6283215 - Jpn J Pharmacol. 1982 Feb;32(1):198-201 11427513 - FASEB J. 2001 Jul;15(9):1643-5 16266701 - Eur J Pharmacol. 2005 Nov 21;525(1-3):161-9 4562620 - J Pharmacol Exp Ther. 1972 Oct;183(1):226-34 16862324 - Mem Inst Oswaldo Cruz. 2006 May;101(3):287-90 3736671 - Nature. 1986 Aug 7-13;322(6079):547-9 14692721 - Int J Clin Pharmacol Ther. 2003 Dec;41(12):622-3 8850331 - Biol Pharm Bull. 1996 Feb;19(2):311-4 20020191 - Inflammation. 2010 Jun;33(3):173-9 10444481 - Am J Physiol. 1999 Aug;277(2 Pt 2):H569-75 14635784 - Inflammation. 2003 Oct;27(5):265-80 15187447 - Biol Pharm Bull. 2004 Jun;27(6):916-20 16807693 - Inflamm Res. 2006 Apr;55(4):129-35 D Díaz-Carballo (9372_CR7) 2003; 41 KF Swingle (9372_CR26) 1972; 183 I Vermes (9372_CR19) 1995; 184 G Mariz (9372_CR6) 1974; 1 IB Suffredini (9372_CR9) 2006; 101 AL Coelho (9372_CR18) 2001; 9 M Carvalho (9372_CR28) 2005; 525 TS Frode-Saleh (9372_CR4) 2000; 49 L Zhao (9372_CR23) 2007; 30 M Iinuma (9372_CR13) 1996; 19 AI Khan (9372_CR1) 2003; 27 CE Stauffer (9372_CR16) 1975; 69 M Hiramatsu (9372_CR27) 1982; 32 JSR Teixeira (9372_CR5) 2006; 17 MR Andrade De (9372_CR15) 1998; 47 M Huerta-Reyes (9372_CR8) 2004; 27 RC Santos (9372_CR21) 2010; 33 XW Zhang (9372_CR2) 2001; 133 SR Peraza-Sánchez (9372_CR10) 2007; 78 A Lunardelli (9372_CR20) 2006; 55 T Mikami (9372_CR3) 1983; 95 OA Olajide (9372_CR25) 1999; 66 S Cerrini (9372_CR11) 1993; 32 J Saklatvala (9372_CR24) 1986; 322 JE Valeski (9372_CR22) 2000; 89 KR Gustafson (9372_CR14) 1992; 48 LM Chedier (9372_CR12) 1999; 22 TS Ismail (9372_CR17) 1997; 56
References_xml	– volume: 49 start-page: 330 year: 2000 end-page: 337 ident: CR4 article-title: Synergistic antiinflammatory effect of NF-kappaB inhibitors and steroidal or non steroidal antiinflammatory drugs in the pleural inflammation induced by carrageenan in mice publication-title: Inflammation Research doi: 10.1007/PL00000213 contributor: fullname: Calixto – volume: 33 start-page: 173 year: 2010 end-page: 179 ident: CR21 article-title: Anti-inflammatory and immunomodulatory effects of Ulomoides dermestoides on induced pleurisy in rats and lymphoproliferation publication-title: Inflammation doi: 10.1007/s10753-009-9171-x contributor: fullname: de Oliveira – volume: 48 start-page: 10093 year: 1992 end-page: 10102 ident: CR14 article-title: HIV inhibitory natural-products: 8. The guttiferones, HIV-inhibitory benzophenones from , , , and publication-title: Tetrahedron doi: 10.1016/S0040-4020(01)89039-6 contributor: fullname: Boyd – volume: 41 start-page: 622 year: 2003 end-page: 623 ident: CR7 article-title: Novel antitumoral compound isolated from publication-title: International Journal Clinical Pharmacological Therapy contributor: fullname: Hilger – volume: 56 start-page: 145 year: 1997 end-page: 152 ident: CR17 article-title: Anti-inflammatory activity of Wall and a Lam publication-title: Journal of Ethnopharmacology doi: 10.1016/S0378-8741(96)01523-1 contributor: fullname: Elango – volume: 133 start-page: 413 year: 2001 end-page: 421 ident: CR2 article-title: CXC chemokines, MIP-2 and KC, induce P-selectin-dependent neutrophil rolling and extravascular migration publication-title: Bristish Journal of Pharmacology doi: 10.1038/sj.bjp.0704087 contributor: fullname: Thorlacius – volume: 32 start-page: 1023 year: 1993 end-page: 1028 ident: CR11 article-title: Nemorosonol, a Derivative of tricyclo-[4.3.1.03,7]-decane-7-hydroxy-2,9-dione from publication-title: Phytochemistry doi: 10.1016/0031-9422(93)85248-P contributor: fullname: Pinherio – volume: 17 start-page: 812 year: 2006 end-page: 815 ident: CR5 article-title: A new biphenyl from and a new tocotrienol from publication-title: Journal of the Brazilian Chemical Society doi: 10.1590/S0103-50532006000400027 contributor: fullname: Cruz – volume: 322 start-page: 547 year: 1986 end-page: 549 ident: CR24 article-title: Tumor necrosis factor a stimulates resorption and inhibits synthesis of proteoglycan in cartilage publication-title: Nature doi: 10.1038/322547a0 contributor: fullname: Saklatvala – volume: 183 start-page: 226 year: 1972 end-page: 234 ident: CR26 article-title: Phases of inflammatory response to subcutaneous implantation of cotton pellet and other modifications by certain anti-inflammatory agents publication-title: Journal of Pharmacology and Experimental Therapeutics contributor: fullname: Shideman – volume: 47 start-page: 1431 year: 1998 end-page: 1433 ident: CR15 article-title: Alkyl chromone and other compounds from publication-title: Phytochemistry doi: 10.1016/S0031-9422(97)00746-2 contributor: fullname: Conserva – volume: 32 start-page: 198 year: 1982 end-page: 201 ident: CR27 article-title: Increase in collagen synthesis of cotton pellet granuloma in rats by epidermal growth factor publication-title: Japanese Journal of Pharmacology doi: 10.1254/jjp.32.198 contributor: fullname: Kumegawa – volume: 22 start-page: 527 year: 1999 end-page: 530 ident: CR12 article-title: Comparative methodology for isolation of flavonoid glycosides from Cambess publication-title: Journal High Resolution Chromatograph doi: 10.1002/(SICI)1521-4168(19990901)22:9<527::AID-JHRC527>3.0.CO;2-S contributor: fullname: Kaplan – volume: 95 start-page: 1 year: 1983 end-page: 12 ident: CR3 article-title: Effects of several antiinflamatory drugs on the various parameters involved in the inflammatory response in the rat carragenin-induced pleurisy publication-title: European Journal of Pharmacology doi: 10.1016/0014-2999(83)90261-3 contributor: fullname: Miyasaka – volume: 101 start-page: 287 year: 2006 end-page: 290 ident: CR9 article-title: Antibacterial and cytotoxic activity of Brazilian plant extracts—Clusiaceae publication-title: Memorias do Instituto Oswaldo Cruz doi: 10.1590/S0074-02762006000300011 contributor: fullname: Varella – volume: 89 start-page: 1561 year: 2000 end-page: 1568 ident: CR22 article-title: Effect of early transient adherent leukocytes on venular permeability and endothelial actin cytoskeleton publication-title: Journal of Applied Physiology contributor: fullname: Baldwin – volume: 69 start-page: 646 year: 1975 end-page: 648 ident: CR16 article-title: A linear standard curve for the Folin Lowry determination of protein publication-title: Analytical Biochemistry doi: 10.1016/0003-2697(75)90172-4 contributor: fullname: Stauffer – volume: 9 start-page: 1643 year: 2001 end-page: 1645 ident: CR18 article-title: Interaction of disintegrins with human neutrophils induces cytoskeleton reorganization, focal adhesion kinase activation, and extracellular-regulated kinase-2 nuclear translocation, interfering with the chemotactic function publication-title: The FASEB Journal contributor: fullname: Barja-Fidalgo – volume: 27 start-page: 265 year: 2003 end-page: 280 ident: CR1 article-title: L-Selectin ligands in lymphoid tissues and models of inflammation publication-title: Inflammation doi: 10.1023/A:1026056525755 contributor: fullname: Rajneesh – volume: 66 start-page: 113 year: 1999 end-page: 117 ident: CR25 article-title: Effects of the aqueous extract of stem bark on carrageenan-induced oedema and granuloma tissue formation in rats and mice publication-title: Journal of Ethnopharmacology doi: 10.1016/S0378-8741(99)00006-9 contributor: fullname: Awe – volume: 184 start-page: 39 year: 1995 end-page: 51 ident: CR19 article-title: A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V publication-title: Journal of Immunological Methods doi: 10.1016/0022-1759(95)00072-I contributor: fullname: Reutelingsperger – volume: 55 start-page: 129 year: 2006 end-page: 135 ident: CR20 article-title: Extract of the bristles of Dirphia sp. increases nitric oxide in a rat pleurisy model publication-title: Inflammation Research doi: 10.1007/s00011-006-0008-x contributor: fullname: Oliveira – volume: 1 start-page: 249 year: 1974 end-page: 314 ident: CR6 article-title: Chaves para as espécies de Clusia nativas no Brasil publication-title: Mem do Instituto Biociências de Universidade Federal de Pernambuco contributor: fullname: Mariz – volume: 19 start-page: 311 year: 1996 end-page: 314 ident: CR13 article-title: Antibacterial activity of some benzophenone derivatives against methicillin-resistant publication-title: Biological and Pharmaceutical Bulletin doi: 10.1248/bpb.19.311 contributor: fullname: Shimano – volume: 525 start-page: 161 year: 2005 end-page: 169 ident: CR28 article-title: Effect of mast cells depletion on the failure of neutrophil migration during sepsis publication-title: European Journal of Pharmacology doi: 10.1016/j.ejphar.2005.09.049 contributor: fullname: Cunha – volume: 30 start-page: 213 year: 2007 end-page: 223 ident: CR23 article-title: Inner anti-inflammatory mechanisms of petroleum ether extract from Ledeb publication-title: Inflammation doi: 10.1007/s10753-007-9039-x contributor: fullname: Guo – volume: 78 start-page: 315 year: 2007 end-page: 318 ident: CR10 article-title: Leishmanicidal evaluation of extracts from native plants of the Yucatan peninsula publication-title: Fitoterapia doi: 10.1016/j.fitote.2007.03.013 contributor: fullname: Mut-Martín – volume: 27 start-page: 916 year: 2004 end-page: 920 ident: CR8 article-title: HIV-1 inhibition by extracts of Clusiaceae species from Mexico publication-title: Biological and Pharmaceutical Bulletin doi: 10.1248/bpb.27.916 contributor: fullname: Reyes-Chilpa – volume: 17 start-page: 812 year: 2006 ident: 9372_CR5 publication-title: Journal of the Brazilian Chemical Society doi: 10.1590/S0103-50532006000400027 contributor: fullname: JSR Teixeira – volume: 27 start-page: 916 year: 2004 ident: 9372_CR8 publication-title: Biological and Pharmaceutical Bulletin doi: 10.1248/bpb.27.916 contributor: fullname: M Huerta-Reyes – volume: 95 start-page: 1 year: 1983 ident: 9372_CR3 publication-title: European Journal of Pharmacology doi: 10.1016/0014-2999(83)90261-3 contributor: fullname: T Mikami – volume: 48 start-page: 10093 year: 1992 ident: 9372_CR14 publication-title: Tetrahedron doi: 10.1016/S0040-4020(01)89039-6 contributor: fullname: KR Gustafson – volume: 49 start-page: 330 year: 2000 ident: 9372_CR4 publication-title: Inflammation Research doi: 10.1007/PL00000213 contributor: fullname: TS Frode-Saleh – volume: 27 start-page: 265 year: 2003 ident: 9372_CR1 publication-title: Inflammation doi: 10.1023/A:1026056525755 contributor: fullname: AI Khan – volume: 66 start-page: 113 year: 1999 ident: 9372_CR25 publication-title: Journal of Ethnopharmacology doi: 10.1016/S0378-8741(99)00006-9 contributor: fullname: OA Olajide – volume: 183 start-page: 226 year: 1972 ident: 9372_CR26 publication-title: Journal of Pharmacology and Experimental Therapeutics contributor: fullname: KF Swingle – volume: 47 start-page: 1431 year: 1998 ident: 9372_CR15 publication-title: Phytochemistry doi: 10.1016/S0031-9422(97)00746-2 contributor: fullname: MR Andrade De – volume: 30 start-page: 213 year: 2007 ident: 9372_CR23 publication-title: Inflammation doi: 10.1007/s10753-007-9039-x contributor: fullname: L Zhao – volume: 69 start-page: 646 year: 1975 ident: 9372_CR16 publication-title: Analytical Biochemistry doi: 10.1016/0003-2697(75)90172-4 contributor: fullname: CE Stauffer – volume: 133 start-page: 413 year: 2001 ident: 9372_CR2 publication-title: Bristish Journal of Pharmacology doi: 10.1038/sj.bjp.0704087 contributor: fullname: XW Zhang – volume: 322 start-page: 547 year: 1986 ident: 9372_CR24 publication-title: Nature doi: 10.1038/322547a0 contributor: fullname: J Saklatvala – volume: 33 start-page: 173 year: 2010 ident: 9372_CR21 publication-title: Inflammation doi: 10.1007/s10753-009-9171-x contributor: fullname: RC Santos – volume: 525 start-page: 161 year: 2005 ident: 9372_CR28 publication-title: European Journal of Pharmacology doi: 10.1016/j.ejphar.2005.09.049 contributor: fullname: M Carvalho – volume: 184 start-page: 39 year: 1995 ident: 9372_CR19 publication-title: Journal of Immunological Methods doi: 10.1016/0022-1759(95)00072-I contributor: fullname: I Vermes – volume: 32 start-page: 1023 year: 1993 ident: 9372_CR11 publication-title: Phytochemistry doi: 10.1016/0031-9422(93)85248-P contributor: fullname: S Cerrini – volume: 1 start-page: 249 year: 1974 ident: 9372_CR6 publication-title: Mem do Instituto Biociências de Universidade Federal de Pernambuco contributor: fullname: G Mariz – volume: 22 start-page: 527 year: 1999 ident: 9372_CR12 publication-title: Journal High Resolution Chromatograph doi: 10.1002/(SICI)1521-4168(19990901)22:9<527::AID-JHRC527>3.0.CO;2-S contributor: fullname: LM Chedier – volume: 9 start-page: 1643 year: 2001 ident: 9372_CR18 publication-title: The FASEB Journal doi: 10.1096/fj.00-0812fje contributor: fullname: AL Coelho – volume: 32 start-page: 198 year: 1982 ident: 9372_CR27 publication-title: Japanese Journal of Pharmacology doi: 10.1254/jjp.32.198 contributor: fullname: M Hiramatsu – volume: 101 start-page: 287 year: 2006 ident: 9372_CR9 publication-title: Memorias do Instituto Oswaldo Cruz doi: 10.1590/S0074-02762006000300011 contributor: fullname: IB Suffredini – volume: 56 start-page: 145 year: 1997 ident: 9372_CR17 publication-title: Journal of Ethnopharmacology doi: 10.1016/S0378-8741(96)01523-1 contributor: fullname: TS Ismail – volume: 89 start-page: 1561 year: 2000 ident: 9372_CR22 publication-title: Journal of Applied Physiology doi: 10.1152/jappl.2000.89.4.1561 contributor: fullname: JE Valeski – volume: 41 start-page: 622 year: 2003 ident: 9372_CR7 publication-title: International Journal Clinical Pharmacological Therapy doi: 10.5414/CPP41622 contributor: fullname: D Díaz-Carballo – volume: 19 start-page: 311 year: 1996 ident: 9372_CR13 publication-title: Biological and Pharmaceutical Bulletin doi: 10.1248/bpb.19.311 contributor: fullname: M Iinuma – volume: 78 start-page: 315 year: 2007 ident: 9372_CR10 publication-title: Fitoterapia doi: 10.1016/j.fitote.2007.03.013 contributor: fullname: SR Peraza-Sánchez – volume: 55 start-page: 129 year: 2006 ident: 9372_CR20 publication-title: Inflammation Research doi: 10.1007/s00011-006-0008-x contributor: fullname: A Lunardelli
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Snippet	The present study was carried out to investigate the anti-inflammatory effect of the hexane extract of the leaves from Clusia nemorosa G. Mey, called HECn,... The present study was carried out to investigate the anti-inflammatory effect of the hexane extract of the leaves from Clusia nemorosa G. Mey, called HECn,...
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SubjectTerms	Animals Anti-Inflammatory Agents - pharmacology Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Carrageenan Cells, Cultured Chemotaxis, Leukocyte - drug effects Clusia Cotton Fiber Granuloma - chemically induced Granuloma - drug therapy Granuloma - immunology Humans Immunology Internal Medicine Mice Neutrophils - immunology Neutrophils - physiology Pathology Pharmacology/Toxicology Phytotherapy Plant Extracts - pharmacology Plant Leaves Pleurisy - chemically induced Pleurisy - drug therapy Pleurisy - immunology Rheumatology Tumor Necrosis Factor-alpha - biosynthesis
Title	Modulation of Inflammatory Processes by Leaves Extract from Clusia nemorosa Both In Vitro and In Vivo Animal Models
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