Altered Function of Antigen-Presenting Cells in Type 1 Diabetes: A Challenge for Antigen-Specific Immunotherapy?

Type 1 diabetes (T1D) arises from a failure to maintain tolerance to specific β-cell antigens. Antigen-specific immunotherapy (ASIT) aims to reestablish immune tolerance through the supply of pertinent antigens to specific cell types or environments that are suitable for eliciting tolerogenic respon...

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Bibliographic Details
Published in:	Diabetes (New York, N.Y.) Vol. 67; no. 8; pp. 1481 - 1494
Main Authors:	Creusot, Rémi J, Postigo-Fernandez, Jorge, Teteloshvili, Nato
Format:	Journal Article
Language:	English
Published:	United States American Diabetes Association 01-08-2018
Subjects:	Animal models Animals Antigen Presentation - drug effects Antigen-presenting cells Antigen-Presenting Cells - drug effects Antigen-Presenting Cells - immunology Antigen-Presenting Cells - metabolism Antigen-Presenting Cells - pathology Antigens Autoantibodies - analysis Autoantibodies - biosynthesis Autoimmune Diseases - genetics Autoimmune Diseases - immunology Autoimmune Diseases - pathology Autoimmune Diseases - therapy Autoimmunity - drug effects Cells Chemotaxis - drug effects Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - pathology Diabetes Mellitus, Type 1 - therapy Gene polymorphism Genetic Predisposition to Disease Genetics Humans Hypoglycemic Agents - adverse effects Hypoglycemic Agents - therapeutic use Immunological tolerance Immunotherapy Immunotherapy - adverse effects Immunotherapy - trends Methodology Review Models, Immunological Phagocytosis - drug effects Phenols Phenotypes Polymorphism Polymorphism, Genetic
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