Development of biosensor based on imaging ellipsometry and biomedical applications

• Published in: Thin solid films Vol. 519; no. 9; pp. 2750 - 2757
• Main Authors: Jin, G., Meng, Y.H., Liu, L., Niu, Y., Chen, S., Cai, Q., Jiang, T.J.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier B.V 28-02-2011; Elsevier
• Subjects: Arrays; Biosensor; Biosensors; Channels; Charge coupled devices; Ellipsometry; Exact sciences and technology; Imaging; Imaging ellipsometry; Instruments, apparatus, components and techniques common to several branches of physics and astronomy; Markers; Microfluidics; Optical instruments, equipment and techniques; Physics; Polarimeters and ellipsometers; Protein microarray; Total internal reflection; Imaging ellipsometry; Total internal reflection; Protein microarray; Biosensor; Charge coupled devices; Macromolecules; Antibodies; Viruses; Time resolved spectra; Optimization; Ellipsometry; Proteins; Time resolution; Imaging; Biosensors; Arrays; Medical application; Microfluidics
• ISSN: 0040-6090; 1879-2731
• DOI: 10.1016/j.tsf.2010.12.175

So far, combined with a microfluidic reactor array system, an engineering system of biosensor based on imaging ellipsometry is installed for biomedical applications, such as antibody screen, hepatitis B markers detection, cancer markers spectrum and virus recognition, etc. Furthermore, the biosensor in total internal reflection (TIR) mode has be improved by a spectroscopic light, optimization settings of polarization and low noise CCD which brings an obvious improvement of 10 time increase in the sensitivity and SNR, and 50 times lower concentration in the detection limit with a throughput of 48 independent channels and the time resolution of 0.04S.