The Relationship Between Tumor-Infiltrating Lymphocytes, PD-L1 Expression, Driver Mutations and Clinical Outcome Parameters in Non-Small Cell Lung Cancer Adenocarcinoma in Patients with a Limited to no Smoking History

Tumor infiltrating lymphocytes (TIL), programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1) expression are important prognostic markers. This study aimed to investigate these markers in lung adenocarcinoma (ADC) biopsies from patients with stage IIIB or IV ADC with little or no smoking his...

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Bibliographic Details
Published in:	Pathology oncology research Vol. 26; no. 2; pp. 1221 - 1228
Main Authors:	Mignon, Sacha, Willard-Gallo, Karen, Van den Eynden, Gert, Salgado, Roberto, Decoster, Lore, Marien, Koen M., Vansteenkiste, Johan F., Teugels, Erik, De Grève, Jacques
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer Netherlands 01-04-2020 Springer Nature B.V
Subjects:	Adenocarcinoma Adenocarcinoma of Lung - genetics Adenocarcinoma of Lung - immunology Adult Aged Apoptosis B7-H1 Antigen - biosynthesis Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - immunology Disease-Free Survival Female Humans Immune response Immunohistochemistry Immunology Infiltration Lung cancer Lymphocytes Lymphocytes, Tumor-Infiltrating - immunology Male Medical prognosis Metastases Middle Aged Mutants Mutation Non-small cell lung carcinoma Oncology Original Article Pathology PD-1 protein PD-L1 protein Prognosis Proto-Oncogene Proteins p21(ras) - genetics Small cell lung carcinoma Smoking Stromal cells Tissue analysis Tumor cells Tumor-infiltrating lymphocytes Tumors Programmed death-1 (PD-1) Lung adenocarcinoma Driver mutations Tumor infiltrating lymphocytes (TIL) Programmed death-ligand 1 (PD-L1)
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