Transformation of epidermal growth factor receptor mutated lung adenocarcinoma to small-cell carcinoma long after the cessation of tyrosine kinase inhibitor treatment: A case series and literature review

Histological transformation to small-cell lung cancer (SCLC) is a well-known mechanism of acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), and almost all patients receive EGFR-TKIs at the time of transformation. We herein report three cases of EGFR-muta...

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Bibliographic Details

Published in:	Respiratory medicine case reports Vol. 51; p. 102076
Main Authors:	Miyamoto, Kenya, Ogino, Hirokazu, Kakimoto, Takumi, Matsumura, Yugo, Haji, Keiko, Mitsuhashi, Atsushi, Morita, Yutaka, Tsukazaki, Yuki, Yabuki, Yohei, Ozaki, Ryohiko, Yoneda, Hiroto, Sato, Seidai, Hanibuchi, Masaki, Bando, Yoshimi, Nokihara, Hiroshi, Nishioka, Yasuhiko
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-01-2024 Elsevier
Subjects:	Acquired resistance Case Report Epidermal growth factor receptor Non-small-cell lung cancer Small-cell lung cancer transformation Tyrosine kinase inhibitors Non-small-cell lung cancer Acquired resistance Epidermal growth factor receptor Tyrosine kinase inhibitors Small-cell lung cancer transformation
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