Depletion of SAM leading to loss of heterochromatin drives muscle stem cell ageing

The global loss of heterochromatin during ageing has been observed in eukaryotes from yeast to humans, and this has been proposed as one of the causes of ageing. However, the cause of this age-associated loss of heterochromatin has remained enigmatic. Here we show that heterochromatin markers, inclu...

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Bibliographic Details
Published in:	Nature metabolism Vol. 6; no. 1; pp. 153 - 168
Main Authors:	Kang, Jengmin, Benjamin, Daniel I., Kim, Soochi, Salvi, Jayesh S., Dhaliwal, Gurkamal, Lam, Richard, Goshayeshi, Armon, Brett, Jamie O., Liu, Ling, Rando, Thomas A.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-01-2024
Subjects:	631/337/100/2285 631/443/319 631/443/7 631/45/320 631/532/2439 Aged Aging Animals Biomedical and Life Sciences Cellular Senescence Female Heterochromatin Humans Life Sciences Male Mice Muscles - metabolism Polyamines - metabolism S-Adenosylmethionine - metabolism
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