Predictive Value of Admission Platelet Volume Indices for In-hospital Major Adverse Cardiovascular Events in Acute ST-Segment Elevation Myocardial Infarction

• Published in: Angiology Vol. 66; no. 2; pp. 155 - 162
• Main Authors: Celik, Turgay, Kaya, Mehmet G., Akpek, Mahmut, Gunebakmaz, Ozgur, Balta, Sevket, Sarli, Bahadir, Duran, Mustafa, Demirkol, Sait, Uysal, Onur Kadir, Oguzhan, Abdurrahman, Gibson, C. Michael
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01-02-2015
• Subjects: Aged; Chi-Square Distribution; Coronary Angiography; Coronary Thrombosis - blood; Coronary Thrombosis - etiology; Coronary Thrombosis - mortality; Female; Hospital Mortality; Humans; Logistic Models; Male; Mean Platelet Volume; Middle Aged; Multivariate Analysis; Myocardial Infarction - blood; Myocardial Infarction - diagnosis; Myocardial Infarction - mortality; Myocardial Infarction - therapy; No-Reflow Phenomenon - blood; No-Reflow Phenomenon - etiology; No-Reflow Phenomenon - mortality; Odds Ratio; Patient Admission; Percutaneous Coronary Intervention - adverse effects; Percutaneous Coronary Intervention - instrumentation; Percutaneous Coronary Intervention - mortality; Predictive Value of Tests; Recurrence; Risk Factors; Stents; Time Factors; Treatment Outcome; Turkey; Turkey; platelet distribution width; ST-segment elevation myocardial infarction; in-hospital prognosis; primary percutaneous coronary intervention; mean platelet volume
• ISSN: 0003-3197; 1940-1574
• DOI: 10.1177/0003319713513493

Although mean platelet volume (MPV) is an independent correlate of impaired angiographic reperfusion and 6-month mortality in ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI), there is less data regarding the association between platelet distribution width (PDW) and in-hospital major adverse cardiovascular events (MACEs). A total of 306 patients with STEMI pPCI were evaluated. No reflow was defined as a post-PCI thrombolysis in myocardial infarction (TIMI) flow grade of 0, 1, or 2 (group 1). Angiographic success was defined as TIMI flow grade 3 (group 2). The values of MPV and PDW were higher among patients with no reflow. In-stent thrombosis, nonfatal myocardial infarction, in-hospital mortality, and MACEs were significantly more frequent among patients with no reflow. In multivariate analysis, PDW, MPV, high-sensitivity C-reactive protein, and glucose on admission were independent correlates of in-hospital MACEs. Admission PDW and MPV are independent correlates of no reflow and in-hospital MACEs among patients with STEMI undergoing pPCI.