Immunological correlates of suicidality among adolescents with internalizing symptoms
Suicide is a leading cause of death in adolescents and young adults globally. Well-established risk factors for suicide are depression and past suicide attempts. People experiencing suicidality may represent a distinct neurobiological group of people with depression. Because converging evidence has...
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| Published in: | Brain, behavior, & immunity. Health Vol. 41; p. 100866 |
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| Abstract | Suicide is a leading cause of death in adolescents and young adults globally. Well-established risk factors for suicide are depression and past suicide attempts. People experiencing suicidality may represent a distinct neurobiological group of people with depression. Because converging evidence has implicated inflammation in depression, we sought to investigate relationships between suicidality and immune markers in youth experiencing diverse mood and anxiety symptoms. We hypothesized that adolescents with suicidality would exhibit a unique immune signature.
Adolescents underwent semi-structured interviews and completed self-reported measures to assess psychopathology, including suicidality (suicidal ideation, plans, or attempts). Fasting blood samples were collected, cultured with and without lipopolysaccharide (LPS) to stimulate an inflammatory response, and analyzed for 41 immune analytes. To assess how immune function related to suicidality categorically and dimensionally, we conducted group comparisons and correlations while controlling for multiple comparisons using false discovery rate (FDR). To further uncover subtle immune-suicidality relationships, we employed a data-driven approach using factor analysis to extract major immune factors, each of which was subsequently correlated with suicidality measures.
Among 126 participants, 29 were healthy controls and 97 participants had internalizing symptoms; within the clinical group, 57 experienced suicidality. Three immune analytes differed between healthy controls, suicidal, and non-suicidal adolescents with internalizing symptoms in the LPS condition: Flt-3L (pFDR = 0.0246), GM-CSF (pFDR = 0.0246), and IFN-γ (pFDR = 0.0246). These analytes were negatively correlated with the Beck Scale for Suicide Ideation (BSSI): Flt-3L (ρ = −0.19, p = 0.04); GM-CSF (ρ = −0.26, p = 0.004); IFN-γ (ρ =−0.33, p = 0.0003). GM-CSF also negatively correlated with number of suicide attempts (ρ = −0.39, p = 0.003). Factor analysis reduced 41 analytes to several common immune factors across experimental conditions, with Flt-3L, GM-CSF, and IFN-γ all loading heavily onto immune factors that were hypoactive in suicidality. Through this data-driven approach, we detected further associations between suicidality and immune factors across all conditions.
Peripheral immune function may be distinctly altered in adolescent suicidality. Future work should examine immune-suicidality relationships longitudinally.
•Peripheral immune function may be distinctly altered in adolescent suicidality.•Suppressed cytokines (incl. Flt-3L, GM-CSF, and IFN-γ) after an inflammatory stressor may reflect a pro-suicidal immune state.•Factor analysis showed Flt-3L, GM-CSF, and IFN-γ loading heavily onto immune factors that were hypoactive in suicidality.•Data-driven approach with factor analysis revealed subtle associations between suicidality and immune dysfunction. |
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| AbstractList | Background: Suicide is a leading cause of death in adolescents and young adults globally. Well-established risk factors for suicide are depression and past suicide attempts. People experiencing suicidality may represent a distinct neurobiological group of people with depression. Because converging evidence has implicated inflammation in depression, we sought to investigate relationships between suicidality and immune markers in youth experiencing diverse mood and anxiety symptoms. We hypothesized that adolescents with suicidality would exhibit a unique immune signature. Methods: Adolescents underwent semi-structured interviews and completed self-reported measures to assess psychopathology, including suicidality (suicidal ideation, plans, or attempts). Fasting blood samples were collected, cultured with and without lipopolysaccharide (LPS) to stimulate an inflammatory response, and analyzed for 41 immune analytes. To assess how immune function related to suicidality categorically and dimensionally, we conducted group comparisons and correlations while controlling for multiple comparisons using false discovery rate (FDR). To further uncover subtle immune-suicidality relationships, we employed a data-driven approach using factor analysis to extract major immune factors, each of which was subsequently correlated with suicidality measures. Results: Among 126 participants, 29 were healthy controls and 97 participants had internalizing symptoms; within the clinical group, 57 experienced suicidality. Three immune analytes differed between healthy controls, suicidal, and non-suicidal adolescents with internalizing symptoms in the LPS condition: Flt-3L (pFDR = 0.0246), GM-CSF (pFDR = 0.0246), and IFN-γ (pFDR = 0.0246). These analytes were negatively correlated with the Beck Scale for Suicide Ideation (BSSI): Flt-3L (ρ = −0.19, p = 0.04); GM-CSF (ρ = −0.26, p = 0.004); IFN-γ (ρ =−0.33, p = 0.0003). GM-CSF also negatively correlated with number of suicide attempts (ρ = −0.39, p = 0.003). Factor analysis reduced 41 analytes to several common immune factors across experimental conditions, with Flt-3L, GM-CSF, and IFN-γ all loading heavily onto immune factors that were hypoactive in suicidality. Through this data-driven approach, we detected further associations between suicidality and immune factors across all conditions. Conclusions: Peripheral immune function may be distinctly altered in adolescent suicidality. Future work should examine immune-suicidality relationships longitudinally. Suicide is a leading cause of death in adolescents and young adults globally. Well-established risk factors for suicide are depression and past suicide attempts. People experiencing suicidality may represent a distinct neurobiological group of people with depression. Because converging evidence has implicated inflammation in depression, we sought to investigate relationships between suicidality and immune markers in youth experiencing diverse mood and anxiety symptoms. We hypothesized that adolescents with suicidality would exhibit a unique immune signature. Adolescents underwent semi-structured interviews and completed self-reported measures to assess psychopathology, including suicidality (suicidal ideation, plans, or attempts). Fasting blood samples were collected, cultured with and without lipopolysaccharide (LPS) to stimulate an inflammatory response, and analyzed for 41 immune analytes. To assess how immune function related to suicidality categorically and dimensionally, we conducted group comparisons and correlations while controlling for multiple comparisons using false discovery rate (FDR). To further uncover subtle immune-suicidality relationships, we employed a data-driven approach using factor analysis to extract major immune factors, each of which was subsequently correlated with suicidality measures. Among 126 participants, 29 were healthy controls and 97 participants had internalizing symptoms; within the clinical group, 57 experienced suicidality. Three immune analytes differed between healthy controls, suicidal, and non-suicidal adolescents with internalizing symptoms in the LPS condition: Flt-3L ( = 0.0246), GM-CSF ( = 0.0246), and IFN-γ ( = 0.0246). These analytes were negatively correlated with the Beck Scale for Suicide Ideation (BSSI): Flt-3L (ρ = -0.19, = 0.04); GM-CSF ( 0.26, = 0.004); IFN-γ ( 0.33, = 0.0003). GM-CSF also negatively correlated with number of suicide attempts (ρ = -0.39, = 0.003). Factor analysis reduced 41 analytes to several common immune factors across experimental conditions, with Flt-3L, GM-CSF, and IFN-γ all loading heavily onto immune factors that were hypoactive in suicidality. Through this data-driven approach, we detected further associations between suicidality and immune factors across all conditions. Peripheral immune function may be distinctly altered in adolescent suicidality. Future work should examine immune-suicidality relationships longitudinally. • Peripheral immune function may be distinctly altered in adolescent suicidality. • Suppressed cytokines (incl. Flt-3L, GM-CSF, and IFN-γ) after an inflammatory stressor may reflect a pro-suicidal immune state. • Factor analysis showed Flt-3L, GM-CSF, and IFN-γ loading heavily onto immune factors that were hypoactive in suicidality. • Data-driven approach with factor analysis revealed subtle associations between suicidality and immune dysfunction. Suicide is a leading cause of death in adolescents and young adults globally. Well-established risk factors for suicide are depression and past suicide attempts. People experiencing suicidality may represent a distinct neurobiological group of people with depression. Because converging evidence has implicated inflammation in depression, we sought to investigate relationships between suicidality and immune markers in youth experiencing diverse mood and anxiety symptoms. We hypothesized that adolescents with suicidality would exhibit a unique immune signature. Adolescents underwent semi-structured interviews and completed self-reported measures to assess psychopathology, including suicidality (suicidal ideation, plans, or attempts). Fasting blood samples were collected, cultured with and without lipopolysaccharide (LPS) to stimulate an inflammatory response, and analyzed for 41 immune analytes. To assess how immune function related to suicidality categorically and dimensionally, we conducted group comparisons and correlations while controlling for multiple comparisons using false discovery rate (FDR). To further uncover subtle immune-suicidality relationships, we employed a data-driven approach using factor analysis to extract major immune factors, each of which was subsequently correlated with suicidality measures. Among 126 participants, 29 were healthy controls and 97 participants had internalizing symptoms; within the clinical group, 57 experienced suicidality. Three immune analytes differed between healthy controls, suicidal, and non-suicidal adolescents with internalizing symptoms in the LPS condition: Flt-3L (pFDR = 0.0246), GM-CSF (pFDR = 0.0246), and IFN-γ (pFDR = 0.0246). These analytes were negatively correlated with the Beck Scale for Suicide Ideation (BSSI): Flt-3L (ρ = −0.19, p = 0.04); GM-CSF (ρ = −0.26, p = 0.004); IFN-γ (ρ =−0.33, p = 0.0003). GM-CSF also negatively correlated with number of suicide attempts (ρ = −0.39, p = 0.003). Factor analysis reduced 41 analytes to several common immune factors across experimental conditions, with Flt-3L, GM-CSF, and IFN-γ all loading heavily onto immune factors that were hypoactive in suicidality. Through this data-driven approach, we detected further associations between suicidality and immune factors across all conditions. Peripheral immune function may be distinctly altered in adolescent suicidality. Future work should examine immune-suicidality relationships longitudinally. •Peripheral immune function may be distinctly altered in adolescent suicidality.•Suppressed cytokines (incl. Flt-3L, GM-CSF, and IFN-γ) after an inflammatory stressor may reflect a pro-suicidal immune state.•Factor analysis showed Flt-3L, GM-CSF, and IFN-γ loading heavily onto immune factors that were hypoactive in suicidality.•Data-driven approach with factor analysis revealed subtle associations between suicidality and immune dysfunction. Suicide is a leading cause of death in adolescents and young adults globally. Well-established risk factors for suicide are depression and past suicide attempts. People experiencing suicidality may represent a distinct neurobiological group of people with depression. Because converging evidence has implicated inflammation in depression, we sought to investigate relationships between suicidality and immune markers in youth experiencing diverse mood and anxiety symptoms. We hypothesized that adolescents with suicidality would exhibit a unique immune signature.BackgroundSuicide is a leading cause of death in adolescents and young adults globally. Well-established risk factors for suicide are depression and past suicide attempts. People experiencing suicidality may represent a distinct neurobiological group of people with depression. Because converging evidence has implicated inflammation in depression, we sought to investigate relationships between suicidality and immune markers in youth experiencing diverse mood and anxiety symptoms. We hypothesized that adolescents with suicidality would exhibit a unique immune signature.Adolescents underwent semi-structured interviews and completed self-reported measures to assess psychopathology, including suicidality (suicidal ideation, plans, or attempts). Fasting blood samples were collected, cultured with and without lipopolysaccharide (LPS) to stimulate an inflammatory response, and analyzed for 41 immune analytes. To assess how immune function related to suicidality categorically and dimensionally, we conducted group comparisons and correlations while controlling for multiple comparisons using false discovery rate (FDR). To further uncover subtle immune-suicidality relationships, we employed a data-driven approach using factor analysis to extract major immune factors, each of which was subsequently correlated with suicidality measures.MethodsAdolescents underwent semi-structured interviews and completed self-reported measures to assess psychopathology, including suicidality (suicidal ideation, plans, or attempts). Fasting blood samples were collected, cultured with and without lipopolysaccharide (LPS) to stimulate an inflammatory response, and analyzed for 41 immune analytes. To assess how immune function related to suicidality categorically and dimensionally, we conducted group comparisons and correlations while controlling for multiple comparisons using false discovery rate (FDR). To further uncover subtle immune-suicidality relationships, we employed a data-driven approach using factor analysis to extract major immune factors, each of which was subsequently correlated with suicidality measures.Among 126 participants, 29 were healthy controls and 97 participants had internalizing symptoms; within the clinical group, 57 experienced suicidality. Three immune analytes differed between healthy controls, suicidal, and non-suicidal adolescents with internalizing symptoms in the LPS condition: Flt-3L (p FDR = 0.0246), GM-CSF (p FDR = 0.0246), and IFN-γ (p FDR = 0.0246). These analytes were negatively correlated with the Beck Scale for Suicide Ideation (BSSI): Flt-3L (ρ = -0.19, p = 0.04); GM-CSF (ρ = -0.26, p = 0.004); IFN-γ (ρ =-0.33, p = 0.0003). GM-CSF also negatively correlated with number of suicide attempts (ρ = -0.39, p = 0.003). Factor analysis reduced 41 analytes to several common immune factors across experimental conditions, with Flt-3L, GM-CSF, and IFN-γ all loading heavily onto immune factors that were hypoactive in suicidality. Through this data-driven approach, we detected further associations between suicidality and immune factors across all conditions.ResultsAmong 126 participants, 29 were healthy controls and 97 participants had internalizing symptoms; within the clinical group, 57 experienced suicidality. Three immune analytes differed between healthy controls, suicidal, and non-suicidal adolescents with internalizing symptoms in the LPS condition: Flt-3L (p FDR = 0.0246), GM-CSF (p FDR = 0.0246), and IFN-γ (p FDR = 0.0246). These analytes were negatively correlated with the Beck Scale for Suicide Ideation (BSSI): Flt-3L (ρ = -0.19, p = 0.04); GM-CSF (ρ = -0.26, p = 0.004); IFN-γ (ρ =-0.33, p = 0.0003). GM-CSF also negatively correlated with number of suicide attempts (ρ = -0.39, p = 0.003). Factor analysis reduced 41 analytes to several common immune factors across experimental conditions, with Flt-3L, GM-CSF, and IFN-γ all loading heavily onto immune factors that were hypoactive in suicidality. Through this data-driven approach, we detected further associations between suicidality and immune factors across all conditions.Peripheral immune function may be distinctly altered in adolescent suicidality. Future work should examine immune-suicidality relationships longitudinally.ConclusionsPeripheral immune function may be distinctly altered in adolescent suicidality. Future work should examine immune-suicidality relationships longitudinally. |
| ArticleNumber | 100866 |
| Author | Gabbay, Vilma Tobe, Russell H. Roske, Chloe Schwartz, Joshua J. Nguyen, Tram N.B. Nie, Kai Mowrey, Wenzhu Erulker, Ava Kim-Schulze, Seunghee Ely, Benjamin A. Xie, Hui |
| Author_xml | – sequence: 1 givenname: Chloe orcidid: 0000-0002-3365-7485 surname: Roske fullname: Roske, Chloe organization: Department of Psychology, Harvard University, Cambridge, MA, USA – sequence: 2 givenname: Tram N.B. surname: Nguyen fullname: Nguyen, Tram N.B. organization: Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY, USA – sequence: 3 givenname: Joshua J. surname: Schwartz fullname: Schwartz, Joshua J. organization: Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY, USA – sequence: 4 givenname: Ava surname: Erulker fullname: Erulker, Ava organization: Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY, USA – sequence: 5 givenname: Kai surname: Nie fullname: Nie, Kai organization: Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA – sequence: 6 givenname: Hui surname: Xie fullname: Xie, Hui organization: Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA – sequence: 7 givenname: Seunghee surname: Kim-Schulze fullname: Kim-Schulze, Seunghee organization: Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA – sequence: 8 givenname: Benjamin A. surname: Ely fullname: Ely, Benjamin A. organization: Department of Psychiatry and Behavioral Sciences, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA – sequence: 9 givenname: Russell H. surname: Tobe fullname: Tobe, Russell H. organization: Department of Clinical Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA – sequence: 10 givenname: Wenzhu surname: Mowrey fullname: Mowrey, Wenzhu organization: Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA – sequence: 11 givenname: Vilma orcidid: 0000-0001-8819-5137 surname: Gabbay fullname: Gabbay, Vilma email: vxg595@med.miami.edu organization: Department of Psychiatry and Behavioral Sciences, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39350953$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.socscimed.2007.08.031 10.1089/cap.2008.0140 10.1007/s00702-011-0685-7 10.1016/j.jpsychires.2011.08.006 10.1192/bjp.167.1.99 10.1080/13811110903266418 10.1177/0004867413488220 10.1016/j.bbi.2022.07.001 10.1002/hup.2698 10.1515/bmc-2018-0007 10.3389/fimmu.2015.00539 10.3390/ijerph17072393 10.1038/nri.2015.5 10.1097/00004583-199707000-00021 10.1016/S0887-6185(99)00009-2 10.1016/S0006-8993(98)01288-8 10.1016/j.biopsych.2015.04.008 10.1016/j.neubiorev.2010.01.003 10.1016/0006-3223(90)90016-U 10.1016/j.psychres.2015.03.031 10.1016/S1046-2023(02)00359-6 10.1016/j.cyto.2008.01.006 10.1016/j.psyneuen.2015.10.008 10.1017/S0033291715001804 10.1038/s41398-020-00920-4 10.1016/S2215-0366(19)30030-6 10.1097/MOP.0b013e32833063e1 10.1089/cap.2014.0105 10.1016/j.jneuroim.2005.08.014 10.1002/(SICI)1099-1700(200004)16:3<133::AID-SMI876>3.0.CO;2-9 10.1016/j.bbi.2019.04.014 10.1016/j.bbi.2015.02.004 10.1038/srep26996 10.1111/j.1749-6632.1998.tb09558.x 10.1371/journal.pone.0165799 10.1002/jcv2.12148 10.1111/j.2517-6161.1995.tb02031.x 10.1007/s12026-014-8517-0 10.1016/j.pnpbp.2007.08.041 10.3389/fpsyt.2013.00152 10.1037/0021-843X.103.2.302 10.1111/nyas.13217 10.2190/PM.43.1.a 10.1016/j.bbi.2022.07.163 10.1016/j.cyto.2014.10.030 10.1038/nrn2297 10.3389/fpsyt.2021.678709 10.1056/NEJM199801153380307 10.1080/15622975.2018.1482000 10.1080/15622975.2019.1618494 10.1016/j.npbr.2020.02.009 10.1007/s10802-023-01033-4 10.1002/eji.201444960 10.1186/s13075-016-1072-4 10.1186/s12974-022-02663-z 10.1016/j.bbi.2010.10.010 10.3389/fimmu.2022.1058963 10.1006/mcne.2001.1033 10.3389/fncel.2013.00068 10.1146/annurev-clinpsy-050718-095625 10.1001/archpsyc.1996.01830040075012 10.1080/15622975.2022.2045354 10.1111/j.1469-7610.2010.02245.x 10.3389/fpsyt.2019.00030 10.1016/j.jpsychires.2015.05.007 10.1523/JNEUROSCI.5321-06.2007 10.1097/PSY.0b013e31820ad12b 10.1016/j.jad.2008.07.022 |
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| Keywords | BSSI Adolescence Cytokines Suicide Chemokines Hematopoietic growth factors |
| Language | English |
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| References | Zunszain, Hepgul, Pariante (bib77) 2013 Benjamini, Hochberg (bib7) 1995; 57 Gabbay (bib27) 2015; 25 (bib14) 2023 Snaith (bib71) 1995; 167 Janelidze, Mattei, Westrin, Träskman-Bendz, Brundin (bib33) 2011; 25 Ganança (bib29) 2016; 63 Freed (bib22) 2019; 20 Lellahi (bib40) 2023; 13 O'Shea, Gadina, Siegel (bib61) 2013 Galbo, Kall (bib28) 2016; 18 Henderson (bib30) 2013; 4 Dhabhar (bib18) 2014; 58 Wong (bib76) 2008; 66 Himmerich, Patsalos, Lichtblau, Ibrahim, Dalton (bib31) 2019; 10 Miller, Raison (bib52) 2016; 16 Beck, Steer, Brown (bib5) 1987 Kaufman (bib36) 1997; 36 Naudé (bib56) 2022; 105 Liu, Zhu, Mi, Jin (bib44) 2022; 19 Shaffer (bib69) 1996; 53 Stetler, Miller (bib72) 2011; 73 Curtin, Garnett (bib16) 2023 Joseph, Golden (bib34) 2017; 1391 Ely, Nguyen, Tobe, Walker, Gabbay (bib20) 2021; 12 May, Klonsky (bib49) 2016; 23 Mindt, Neumaier, Hoyer, Sartorius, Kranaster (bib53) 2020; 21 Ottum, Arellano, Reyes, Iruretagoyena, Naves (bib60) 2015; 6 Vogel (bib74) 2015; 45 Nilsonne, Lekander, Åkerstedt, Axelsson, Ingre (bib58) 2016; 11 Kim (bib38) 2012; 43 Gabbay (bib25) 2010; 51 Atake (bib2) 2022; 23 Brazel, Ducceschi, Pytowski, Levison (bib10) 2001; 18 Makhija, Karunakaran (bib46) 2013; 47 Pandey (bib63) 2012; 46 van Eeden (bib73) 2020; 10 Lacosta, Merali, Anisman (bib39) 1999; 818 Beck, Steer (bib4) 1991; vol. 63 bib1 Pavón (bib64) 2006; 172 Gabbay (bib23) 2009; 19 March, Sullivan, Parker (bib47) 1999; 13 McEwen (bib50) 1998; 338 Omrani (bib59) 2009; 13 Miyauchi (bib54) 2019; 34 Gabbay, Ely, Babb, Liebes (bib26) 2012; 119 Audet, Anisman (bib3) 2013; 7 Gabbay (bib24) 2009; 115 Bellato (bib6) 2023; 3 Cash, Bridge (bib13) 2009; 21 Clayton (bib15) 2023 Lewinsohn (bib42) 1994; 103 Lu, Yeh, Ohashi (bib45) 2008; 42 Poznanski (bib65) 1984 Pandey (bib62) 2015; 78 Breen, Polaskova, Khan (bib11) 2015; 71 Serafini (bib68) 2020; 17 Dantzer, O'Connor, Freund, Johnson, Kelley (bib17) 2008; 9 Slavich, O'Donovan, Epel, Kemeny (bib70) 2010; 35 Ribeiro (bib67) 2016; 46 Bradley (bib9) 2019; 80 Mars (bib48) 2019; 6 Breen, Tan, Khan (bib12) 2016; 6 Kim (bib37) 2008; 32 Irwin (bib32) 1990; 27 Wang (bib75) 2020; 36 Bradley (bib8) 2015; 227 Réus (bib66) 2015; 68 Kak, Raza, Tiwari (bib35) 2018; 9 Mount (bib55) 2007; 27 Nguyen (bib57) 2022; 106 Linthorst, Reul (bib43) 1998; 840 Ducasse, Olié, Guillaume, Artéro, Courtet (bib19) 2015; 46 Eugenin, Berman (bib21) 2003; 29 Miller, Prinstein (bib51) 2019; 15 Leonard (bib41) 2000; 16 Linthorst (10.1016/j.bbih.2024.100866_bib43) 1998; 840 Pandey (10.1016/j.bbih.2024.100866_bib63) 2012; 46 Benjamini (10.1016/j.bbih.2024.100866_bib7) 1995; 57 Himmerich (10.1016/j.bbih.2024.100866_bib31) 2019; 10 Makhija (10.1016/j.bbih.2024.100866_bib46) 2013; 47 Zunszain (10.1016/j.bbih.2024.100866_bib77) 2013 Serafini (10.1016/j.bbih.2024.100866_bib68) 2020; 17 March (10.1016/j.bbih.2024.100866_bib47) 1999; 13 Brazel (10.1016/j.bbih.2024.100866_bib10) 2001; 18 Beck (10.1016/j.bbih.2024.100866_bib5) 1987 Gabbay (10.1016/j.bbih.2024.100866_bib25) 2010; 51 Ganança (10.1016/j.bbih.2024.100866_bib29) 2016; 63 Curtin (10.1016/j.bbih.2024.100866_bib16) Réus (10.1016/j.bbih.2024.100866_bib66) 2015; 68 Gabbay (10.1016/j.bbih.2024.100866_bib26) 2012; 119 Breen (10.1016/j.bbih.2024.100866_bib12) 2016; 6 Gabbay (10.1016/j.bbih.2024.100866_bib23) 2009; 19 Kim (10.1016/j.bbih.2024.100866_bib37) 2008; 32 Mount (10.1016/j.bbih.2024.100866_bib55) 2007; 27 Mindt (10.1016/j.bbih.2024.100866_bib53) 2020; 21 Breen (10.1016/j.bbih.2024.100866_bib11) 2015; 71 Vogel (10.1016/j.bbih.2024.100866_bib74) 2015; 45 Dantzer (10.1016/j.bbih.2024.100866_bib17) 2008; 9 van Eeden (10.1016/j.bbih.2024.100866_bib73) 2020; 10 Pandey (10.1016/j.bbih.2024.100866_bib62) 2015; 78 Ely (10.1016/j.bbih.2024.100866_bib20) 2021; 12 Lewinsohn (10.1016/j.bbih.2024.100866_bib42) 1994; 103 Gabbay (10.1016/j.bbih.2024.100866_bib27) 2015; 25 Eugenin (10.1016/j.bbih.2024.100866_bib21) 2003; 29 May (10.1016/j.bbih.2024.100866_bib49) 2016; 23 Slavich (10.1016/j.bbih.2024.100866_bib70) 2010; 35 Henderson (10.1016/j.bbih.2024.100866_bib30) 2013; 4 Mars (10.1016/j.bbih.2024.100866_bib48) 2019; 6 Nilsonne (10.1016/j.bbih.2024.100866_bib58) 2016; 11 Ducasse (10.1016/j.bbih.2024.100866_bib19) 2015; 46 Bradley (10.1016/j.bbih.2024.100866_bib9) 2019; 80 McEwen (10.1016/j.bbih.2024.100866_bib50) 1998; 338 Miyauchi (10.1016/j.bbih.2024.100866_bib54) 2019; 34 Janelidze (10.1016/j.bbih.2024.100866_bib33) 2011; 25 Naudé (10.1016/j.bbih.2024.100866_bib56) 2022; 105 Clayton (10.1016/j.bbih.2024.100866_bib15) 2023 Kak (10.1016/j.bbih.2024.100866_bib35) 2018; 9 Lellahi (10.1016/j.bbih.2024.100866_bib40) 2023; 13 Freed (10.1016/j.bbih.2024.100866_bib22) 2019; 20 Gabbay (10.1016/j.bbih.2024.100866_bib24) 2009; 115 Kim (10.1016/j.bbih.2024.100866_bib38) 2012; 43 Nguyen (10.1016/j.bbih.2024.100866_bib57) 2022; 106 Snaith (10.1016/j.bbih.2024.100866_bib71) 1995; 167 Audet (10.1016/j.bbih.2024.100866_bib3) 2013; 7 Poznanski (10.1016/j.bbih.2024.100866_bib65) 1984 Cash (10.1016/j.bbih.2024.100866_bib13) 2009; 21 Leonard (10.1016/j.bbih.2024.100866_bib41) 2000; 16 Ottum (10.1016/j.bbih.2024.100866_bib60) 2015; 6 O'Shea (10.1016/j.bbih.2024.100866_bib61) 2013 Kaufman (10.1016/j.bbih.2024.100866_bib36) 1997; 36 Dhabhar (10.1016/j.bbih.2024.100866_bib18) 2014; 58 Joseph (10.1016/j.bbih.2024.100866_bib34) 2017; 1391 Ribeiro (10.1016/j.bbih.2024.100866_bib67) 2016; 46 Bradley (10.1016/j.bbih.2024.100866_bib8) 2015; 227 Atake (10.1016/j.bbih.2024.100866_bib2) 2022; 23 Omrani (10.1016/j.bbih.2024.100866_bib59) 2009; 13 Liu (10.1016/j.bbih.2024.100866_bib44) 2022; 19 Beck (10.1016/j.bbih.2024.100866_bib4) 1991; vol. 63 Stetler (10.1016/j.bbih.2024.100866_bib72) 2011; 73 Wang (10.1016/j.bbih.2024.100866_bib75) 2020; 36 Shaffer (10.1016/j.bbih.2024.100866_bib69) 1996; 53 Lacosta (10.1016/j.bbih.2024.100866_bib39) 1999; 818 Galbo (10.1016/j.bbih.2024.100866_bib28) 2016; 18 Lu (10.1016/j.bbih.2024.100866_bib45) 2008; 42 Irwin (10.1016/j.bbih.2024.100866_bib32) 1990; 27 Wong (10.1016/j.bbih.2024.100866_bib76) 2008; 66 Bellato (10.1016/j.bbih.2024.100866_bib6) 2023; 3 Miller (10.1016/j.bbih.2024.100866_bib51) 2019; 15 Miller (10.1016/j.bbih.2024.100866_bib52) 2016; 16 Pavón (10.1016/j.bbih.2024.100866_bib64) 2006; 172 |
| References_xml | – volume: 119 start-page: 253 year: 2012 end-page: 260 ident: bib26 article-title: The possible role of the kynurenine pathway in anhedonia in adolescents publication-title: J. Neural. Transm. contributor: fullname: Liebes – volume: 167 start-page: 99 year: 1995 end-page: 103 ident: bib71 article-title: A scale for the assessment of hedonic tone the Snaith–Hamilton pleasure scale publication-title: Br. J. Psychiatry contributor: fullname: Snaith – volume: 78 start-page: 5 year: 2015 end-page: 6 ident: bib62 article-title: Cytokines as suicide risk biomarkers publication-title: Biol. Psychiatr. contributor: fullname: Pandey – volume: 6 start-page: 327 year: 2019 end-page: 337 ident: bib48 article-title: Predictors of future suicide attempt among adolescents with suicidal thoughts or non-suicidal self-harm: a population-based birth cohort study publication-title: Lancet Psychiatr. contributor: fullname: Mars – volume: 34 year: 2019 ident: bib54 article-title: Effect of antidepressant treatment on plasma levels of neuroinflammation‐associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region publication-title: Hum. Psychopharmacol. Clin. Exp. contributor: fullname: Miyauchi – volume: 43 start-page: 1 year: 2012 end-page: 17 ident: bib38 article-title: Associations between plasma cytokines and depressive mood in patients with breast cancer publication-title: Int. J. Psychiatr. Med. contributor: fullname: Kim – volume: 58 start-page: 193 year: 2014 end-page: 210 ident: bib18 article-title: Effects of stress on immune function: the good, the bad, and the beautiful publication-title: Immunol. Res. contributor: fullname: Dhabhar – volume: 25 start-page: 335 year: 2011 end-page: 339 ident: bib33 article-title: Cytokine levels in the blood may distinguish suicide attempters from depressed patients publication-title: Brain Behav. Immun. contributor: fullname: Brundin – volume: 19 start-page: 298 year: 2022 ident: bib44 article-title: Impact of disease-modifying therapy on dendritic cells and exploring their immunotherapeutic potential in multiple sclerosis publication-title: J. Neuroinflammation contributor: fullname: Jin – volume: 172 start-page: 156 year: 2006 end-page: 165 ident: bib64 article-title: Th2 cytokine response in Major Depressive Disorder patients before treatment publication-title: J. Neuroimmunol. contributor: fullname: Pavón – volume: 21 start-page: 613 year: 2009 end-page: 619 ident: bib13 article-title: Epidemiology of youth suicide and suicidal behavior publication-title: Curr. Opin. Pediatr. contributor: fullname: Bridge – volume: 818 start-page: 291 year: 1999 end-page: 303 ident: bib39 article-title: Behavioral and neurochemical consequences of lipopolysaccharide in mice: anxiogenic-like effects publication-title: Brain Res. contributor: fullname: Anisman – volume: 46 start-page: 203 year: 2015 end-page: 211 ident: bib19 article-title: A meta-analysis of cytokines in suicidal behavior publication-title: Brain Behav. Immun. contributor: fullname: Courtet – volume: 36 start-page: 980 year: 1997 end-page: 988 ident: bib36 article-title: Schedule for affective disorders and Schizophrenia for school-age children-present and Lifetime version (K-SADS-PL): initial reliability and validity data publication-title: J. Am. Acad. Child Adolesc. Psychiatry contributor: fullname: Kaufman – volume: 29 start-page: 351 year: 2003 end-page: 361 ident: bib21 article-title: Chemokine-dependent mechanisms of leukocyte trafficking across a model of the blood–brain barrier publication-title: Methods contributor: fullname: Berman – volume: 840 start-page: 139 year: 1998 end-page: 152 ident: bib43 article-title: Brain neurotransmission during peripheral inflammationa publication-title: Ann. N. Y. Acad. Sci. contributor: fullname: Reul – volume: 42 start-page: 145 year: 2008 end-page: 151 ident: bib45 article-title: LPS/TLR4 signal transduction pathway publication-title: Cytokine contributor: fullname: Ohashi – volume: 105 start-page: 160 year: 2022 end-page: 168 ident: bib56 article-title: Antenatal maternal depression, early life inflammation and neurodevelopment in a South African birth cohort publication-title: Brain Behav. Immun. contributor: fullname: Naudé – volume: 73 start-page: 114 year: 2011 ident: bib72 article-title: Depression and hypothalamic-pituitary-adrenal activation: a quantitative summary of four decades of research publication-title: Psychosom. Med. contributor: fullname: Miller – volume: 27 start-page: 22 year: 1990 end-page: 30 ident: bib32 article-title: Reduction of immune function in life stress and depression publication-title: Biol. Psychiatr. contributor: fullname: Irwin – volume: 338 start-page: 171 year: 1998 end-page: 179 ident: bib50 article-title: Protective and Damaging effects of stress mediators publication-title: N. Engl. J. Med. contributor: fullname: McEwen – volume: 227 start-page: 206 year: 2015 end-page: 212 ident: bib8 article-title: The role of the kynurenine pathway in suicidality in adolescent major depressive disorder publication-title: Psychiatr. Res. contributor: fullname: Bradley – volume: 106 start-page: 89 year: 2022 end-page: 99 ident: bib57 article-title: Clenbuterol attenuates immune reaction to lipopolysaccharide and its relationship to anhedonia in adolescents publication-title: Brain Behav. Immun. contributor: fullname: Nguyen – volume: 10 start-page: 1 year: 2020 end-page: 12 ident: bib73 article-title: Basal and LPS-stimulated inflammatory markers and the course of individual symptoms of depression publication-title: Transl. Psychiatry contributor: fullname: van Eeden – volume: 103 start-page: 302 year: 1994 end-page: 315 ident: bib42 article-title: Adolescent psychopathology: II. Psychosocial risk factors for depression publication-title: J. Abnorm. Psychol. contributor: fullname: Lewinsohn – volume: 16 start-page: 133 year: 2000 end-page: 137 ident: bib41 article-title: Stress, depression and the immune system publication-title: Stress Med. contributor: fullname: Leonard – volume: 57 start-page: 289 year: 1995 end-page: 300 ident: bib7 article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing publication-title: J. R. Stat. Soc. Ser. B Methodol. contributor: fullname: Hochberg – volume: 3 year: 2023 ident: bib6 article-title: Autonomic dysregulation and self-injurious thoughts and behaviours in children and young people: a systematic review and meta-analysis publication-title: JCPP Adv contributor: fullname: Bellato – volume: vol. 63 year: 1991 ident: bib4 article-title: Manual for the Beck scale for suicide ideation publication-title: San Antonio TX Psychol contributor: fullname: Steer – volume: 10 year: 2019 ident: bib31 article-title: Cytokine research in depression: principles, challenges, and open questions publication-title: Front. Psychiatr. contributor: fullname: Dalton – volume: 21 start-page: 139 year: 2020 end-page: 147 ident: bib53 article-title: Cytokine-mediated cellular immune activation in electroconvulsive therapy: a CSF study in patients with treatment-resistant depression publication-title: World J. Biol. Psychiatr. contributor: fullname: Kranaster – volume: 66 start-page: 232 year: 2008 end-page: 241 ident: bib76 article-title: Repeat suicide attempts in Hong Kong community adolescents publication-title: Soc. Sci. Med. contributor: fullname: Wong – volume: 23 start-page: 785 year: 2022 end-page: 793 ident: bib2 article-title: Pre-treatment plasma cytokine levels as potential predictors of short-term remission of depression publication-title: World J. Biol. Psychiatr. contributor: fullname: Atake – volume: 1391 start-page: 20 year: 2017 end-page: 34 ident: bib34 article-title: Cortisol dysregulation: the bidirectional link between stress, depression, and type 2 diabetes mellitus publication-title: Ann. N. Y. Acad. Sci. contributor: fullname: Golden – volume: 7 year: 2013 ident: bib3 article-title: Interplay between pro-inflammatory cytokines and growth factors in depressive illnesses publication-title: Front. Cell. Neurosci. contributor: fullname: Anisman – year: 2023 ident: bib15 article-title: Interpersonal life stress and inflammatory reactivity as prospective predictors of suicide attempts in adolescent females publication-title: Res. Child Adolesc. Psychopathol. contributor: fullname: Clayton – volume: 13 start-page: 349 year: 1999 end-page: 358 ident: bib47 article-title: Test-retest reliability of the multidimensional anxiety scale for children publication-title: J. Anxiety Disord. contributor: fullname: Parker – year: 2023 ident: bib14 article-title: Disparities in suicide – start-page: 108 year: 2013 end-page: 135 ident: bib61 article-title: Cytokines and cytokine receptors publication-title: Clinical Immunology contributor: fullname: Siegel – volume: 115 start-page: 177 year: 2009 end-page: 182 ident: bib24 article-title: Immune system dysregulation in adolescent major depressive disorder publication-title: J. Affect. Disord. contributor: fullname: Gabbay – volume: 18 start-page: 381 year: 2001 end-page: 393 ident: bib10 article-title: The FLT3 tyrosine kinase receptor inhibits neural stem/progenitor cell proliferation and collaborates with NGF to promote neuronal survival publication-title: Mol. Cell. Neurosci. contributor: fullname: Levison – volume: 12 year: 2021 ident: bib20 article-title: Multimodal investigations of reward circuitry and anhedonia in adolescent depression publication-title: Front. Psychiatr. contributor: fullname: Gabbay – volume: 17 start-page: 2393 year: 2020 ident: bib68 article-title: A specific inflammatory profile underlying suicide risk? Systematic review of the main literature findings publication-title: Int. J. Environ. Res. Publ. Health contributor: fullname: Serafini – ident: bib1 article-title: . World Health Organization – volume: 20 start-page: 712 year: 2019 end-page: 722 ident: bib22 article-title: Anhedonia as a clinical correlate of inflammation in adolescents across psychiatric conditions publication-title: World J. Biol. Psychiatr. contributor: fullname: Freed – volume: 19 start-page: 423 year: 2009 end-page: 430 ident: bib23 article-title: A preliminary study of cytokines in suicidal and nonsuicidal adolescents with major depression publication-title: J. Child Adolesc. Psychopharmacol. contributor: fullname: Gabbay – volume: 32 start-page: 356 year: 2008 end-page: 361 ident: bib37 article-title: Differences in cytokines between non-suicidal patients and suicidal patients in major depression publication-title: Prog. Neuro-Psychopharmacol. Biol. Psychiatry contributor: fullname: Kim – volume: 6 year: 2015 ident: bib60 article-title: Opposing roles of interferon-gamma on cells of the central nervous system in autoimmune neuroinflammation publication-title: Front. Immunol. contributor: fullname: Naves – volume: 53 start-page: 339 year: 1996 end-page: 348 ident: bib69 article-title: Psychiatric diagnosis in child and adolescent suicide publication-title: Arch. Gen. Psychiatr. contributor: fullname: Shaffer – volume: 36 start-page: 39 year: 2020 end-page: 51 ident: bib75 article-title: Cytokine changes in different types of depression: specific or general? publication-title: Neurol. Psychiatr. Brain Res. contributor: fullname: Wang – volume: 80 start-page: 374 year: 2019 end-page: 383 ident: bib9 article-title: Relationships between neural activation during a reward task and peripheral cytokine levels in youth with diverse psychiatric symptoms publication-title: Brain Behav. Immun. contributor: fullname: Bradley – volume: 25 start-page: 194 year: 2015 end-page: 200 ident: bib27 article-title: Anhedonia, but not irritability, is associated with illness severity outcomes in adolescent major depression publication-title: J. Child Adolesc. Psychopharmacol. contributor: fullname: Gabbay – start-page: 135 year: 2013 end-page: 151 ident: bib77 article-title: Inflammation and depression publication-title: Behavioral Neurobiology of Depression and its Treatment contributor: fullname: Pariante – year: 2023 ident: bib16 article-title: Suicide and homicide death rates among youth and young adults aged 10–24: United States, 2001–2021 contributor: fullname: Garnett – volume: 23 start-page: 5 year: 2016 end-page: 20 ident: bib49 article-title: What distinguishes suicide attempters from suicide ideators? A meta‐analysis of potential factors publication-title: Clin. Psychol. Sci. Pract. contributor: fullname: Klonsky – volume: 16 start-page: 22 year: 2016 end-page: 34 ident: bib52 article-title: The role of inflammation in depression: from evolutionary imperative to modern treatment target publication-title: Nat. Rev. Immunol. contributor: fullname: Raison – volume: 13 start-page: 330 year: 2009 end-page: 339 ident: bib59 article-title: Role of IL-10 −1082, IFN-γ +874, and TNF-α −308 genes polymorphisms in suicidal behavior publication-title: Arch. Suicide Res. contributor: fullname: Omrani – year: 1987 ident: bib5 article-title: Beck Depression Inventory contributor: fullname: Brown – year: 1984 ident: bib65 article-title: Children's Depression Rating Scale--Revised contributor: fullname: Poznanski – volume: 46 start-page: 225 year: 2016 end-page: 236 ident: bib67 article-title: Self-injurious thoughts and behaviors as risk factors for future suicide ideation, attempts, and death: a meta-analysis of longitudinal studies publication-title: Psychol. Med. contributor: fullname: Ribeiro – volume: 15 start-page: 425 year: 2019 end-page: 450 ident: bib51 article-title: Adolescent suicide as a failure of acute stress-response systems publication-title: Annu. Rev. Clin. Psychol. contributor: fullname: Prinstein – volume: 45 start-page: 1808 year: 2015 end-page: 1819 ident: bib74 article-title: GM-CSF promotes migration of human monocytes across the blood brain barrier: molecular immunology publication-title: Eur. J. Immunol. contributor: fullname: Vogel – volume: 35 start-page: 39 year: 2010 end-page: 45 ident: bib70 article-title: Black sheep get the blues: a psychobiological model of social rejection and depression publication-title: Neurosci. Biobehav. Rev. contributor: fullname: Kemeny – volume: 9 start-page: 46 year: 2008 end-page: 56 ident: bib17 article-title: From inflammation to sickness and depression: when the immune system subjugates the brain publication-title: Nat. Rev. Neurosci. contributor: fullname: Kelley – volume: 27 start-page: 3328 year: 2007 end-page: 3337 ident: bib55 article-title: Involvement of interferon-γ in microglial-mediated loss of dopaminergic neurons publication-title: J. Neurosci. contributor: fullname: Mount – volume: 68 start-page: 316 year: 2015 end-page: 328 ident: bib66 article-title: Kynurenine pathway dysfunction in the pathophysiology and treatment of depression: evidences from animal and human studies publication-title: J. Psychiatr. Res. contributor: fullname: Réus – volume: 9 start-page: 64 year: 2018 end-page: 79 ident: bib35 article-title: Interferon-gamma (IFN-γ): exploring its implications in infectious diseases publication-title: Biomol. Concepts contributor: fullname: Tiwari – volume: 71 start-page: 188 year: 2015 end-page: 198 ident: bib11 article-title: Bead-based multiplex immuno-assays for cytokines, chemokines, growth factors and other analytes: median fluorescence intensities versus their derived absolute concentration values for statistical analysis publication-title: Cytokine contributor: fullname: Khan – volume: 47 start-page: 828 year: 2013 end-page: 839 ident: bib46 article-title: The role of inflammatory cytokines on the aetiopathogenesis of depression publication-title: Aust. N. Z. J. Psychiatr. contributor: fullname: Karunakaran – volume: 4 start-page: 152 year: 2013 ident: bib30 article-title: A preliminary study of white matter in adolescent depression: relationships with illness severity, anhedonia, and irritability publication-title: Front. Psychiatr. contributor: fullname: Henderson – volume: 6 year: 2016 ident: bib12 article-title: The statistical value of raw fluorescence signal in Luminex xMAP based multiplex immunoassays publication-title: Sci. Rep. contributor: fullname: Khan – volume: 11 year: 2016 ident: bib58 article-title: Diurnal variation of circulating interleukin-6 in humans: a meta-analysis publication-title: PLoS One contributor: fullname: Ingre – volume: 18 start-page: 174 year: 2016 ident: bib28 article-title: Circadian variations in clinical symptoms and concentrations of inflammatory cytokines, melatonin, and cortisol in polymyalgia rheumatica before and during prednisolone treatment: a controlled, observational, clinical experimental study publication-title: Arthritis Res. Ther. contributor: fullname: Kall – volume: 13 year: 2023 ident: bib40 article-title: GM-CSF, Flt3-L and IL-4 affect viability and function of conventional dendritic cell types 1 and 2 publication-title: Front. Immunol. contributor: fullname: Lellahi – volume: 63 start-page: 296 year: 2016 end-page: 310 ident: bib29 article-title: The role of cytokines in the pathophysiology of suicidal behavior publication-title: Psychoneuroendocrinology contributor: fullname: Ganança – volume: 51 start-page: 935 year: 2010 end-page: 943 ident: bib25 article-title: The possible role of the kynurenine pathway in adolescent depression with melancholic features publication-title: JCPP (J. Child Psychol. Psychiatry) contributor: fullname: Gabbay – volume: 46 start-page: 57 year: 2012 end-page: 63 ident: bib63 article-title: Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims publication-title: J. Psychiatr. Res. contributor: fullname: Pandey – volume: 66 start-page: 232 year: 2008 ident: 10.1016/j.bbih.2024.100866_bib76 article-title: Repeat suicide attempts in Hong Kong community adolescents publication-title: Soc. Sci. Med. doi: 10.1016/j.socscimed.2007.08.031 contributor: fullname: Wong – volume: 19 start-page: 423 year: 2009 ident: 10.1016/j.bbih.2024.100866_bib23 article-title: A preliminary study of cytokines in suicidal and nonsuicidal adolescents with major depression publication-title: J. Child Adolesc. Psychopharmacol. doi: 10.1089/cap.2008.0140 contributor: fullname: Gabbay – volume: 119 start-page: 253 year: 2012 ident: 10.1016/j.bbih.2024.100866_bib26 article-title: The possible role of the kynurenine pathway in anhedonia in adolescents publication-title: J. Neural. Transm. doi: 10.1007/s00702-011-0685-7 contributor: fullname: Gabbay – ident: 10.1016/j.bbih.2024.100866_bib16 contributor: fullname: Curtin – volume: 46 start-page: 57 year: 2012 ident: 10.1016/j.bbih.2024.100866_bib63 article-title: Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims publication-title: J. Psychiatr. Res. doi: 10.1016/j.jpsychires.2011.08.006 contributor: fullname: Pandey – volume: 167 start-page: 99 year: 1995 ident: 10.1016/j.bbih.2024.100866_bib71 article-title: A scale for the assessment of hedonic tone the Snaith–Hamilton pleasure scale publication-title: Br. J. Psychiatry doi: 10.1192/bjp.167.1.99 contributor: fullname: Snaith – volume: 13 start-page: 330 year: 2009 ident: 10.1016/j.bbih.2024.100866_bib59 article-title: Role of IL-10 −1082, IFN-γ +874, and TNF-α −308 genes polymorphisms in suicidal behavior publication-title: Arch. Suicide Res. doi: 10.1080/13811110903266418 contributor: fullname: Omrani – volume: 47 start-page: 828 year: 2013 ident: 10.1016/j.bbih.2024.100866_bib46 article-title: The role of inflammatory cytokines on the aetiopathogenesis of depression publication-title: Aust. N. Z. J. Psychiatr. doi: 10.1177/0004867413488220 contributor: fullname: Makhija – volume: 105 start-page: 160 year: 2022 ident: 10.1016/j.bbih.2024.100866_bib56 article-title: Antenatal maternal depression, early life inflammation and neurodevelopment in a South African birth cohort publication-title: Brain Behav. Immun. doi: 10.1016/j.bbi.2022.07.001 contributor: fullname: Naudé – volume: 34 year: 2019 ident: 10.1016/j.bbih.2024.100866_bib54 article-title: Effect of antidepressant treatment on plasma levels of neuroinflammation‐associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region publication-title: Hum. Psychopharmacol. Clin. Exp. doi: 10.1002/hup.2698 contributor: fullname: Miyauchi – start-page: 108 year: 2013 ident: 10.1016/j.bbih.2024.100866_bib61 article-title: Cytokines and cytokine receptors contributor: fullname: O'Shea – volume: 9 start-page: 64 year: 2018 ident: 10.1016/j.bbih.2024.100866_bib35 article-title: Interferon-gamma (IFN-γ): exploring its implications in infectious diseases publication-title: Biomol. Concepts doi: 10.1515/bmc-2018-0007 contributor: fullname: Kak – volume: 6 year: 2015 ident: 10.1016/j.bbih.2024.100866_bib60 article-title: Opposing roles of interferon-gamma on cells of the central nervous system in autoimmune neuroinflammation publication-title: Front. Immunol. doi: 10.3389/fimmu.2015.00539 contributor: fullname: Ottum – volume: 17 start-page: 2393 year: 2020 ident: 10.1016/j.bbih.2024.100866_bib68 article-title: A specific inflammatory profile underlying suicide risk? Systematic review of the main literature findings publication-title: Int. J. Environ. Res. Publ. Health doi: 10.3390/ijerph17072393 contributor: fullname: Serafini – volume: 16 start-page: 22 year: 2016 ident: 10.1016/j.bbih.2024.100866_bib52 article-title: The role of inflammation in depression: from evolutionary imperative to modern treatment target publication-title: Nat. Rev. Immunol. doi: 10.1038/nri.2015.5 contributor: fullname: Miller – volume: 36 start-page: 980 year: 1997 ident: 10.1016/j.bbih.2024.100866_bib36 article-title: Schedule for affective disorders and Schizophrenia for school-age children-present and Lifetime version (K-SADS-PL): initial reliability and validity data publication-title: J. Am. Acad. Child Adolesc. Psychiatry doi: 10.1097/00004583-199707000-00021 contributor: fullname: Kaufman – volume: 13 start-page: 349 year: 1999 ident: 10.1016/j.bbih.2024.100866_bib47 article-title: Test-retest reliability of the multidimensional anxiety scale for children publication-title: J. Anxiety Disord. doi: 10.1016/S0887-6185(99)00009-2 contributor: fullname: March – volume: 818 start-page: 291 year: 1999 ident: 10.1016/j.bbih.2024.100866_bib39 article-title: Behavioral and neurochemical consequences of lipopolysaccharide in mice: anxiogenic-like effects publication-title: Brain Res. doi: 10.1016/S0006-8993(98)01288-8 contributor: fullname: Lacosta – volume: 78 start-page: 5 year: 2015 ident: 10.1016/j.bbih.2024.100866_bib62 article-title: Cytokines as suicide risk biomarkers publication-title: Biol. Psychiatr. doi: 10.1016/j.biopsych.2015.04.008 contributor: fullname: Pandey – volume: 35 start-page: 39 year: 2010 ident: 10.1016/j.bbih.2024.100866_bib70 article-title: Black sheep get the blues: a psychobiological model of social rejection and depression publication-title: Neurosci. Biobehav. Rev. doi: 10.1016/j.neubiorev.2010.01.003 contributor: fullname: Slavich – volume: 27 start-page: 22 year: 1990 ident: 10.1016/j.bbih.2024.100866_bib32 article-title: Reduction of immune function in life stress and depression publication-title: Biol. Psychiatr. doi: 10.1016/0006-3223(90)90016-U contributor: fullname: Irwin – volume: 227 start-page: 206 year: 2015 ident: 10.1016/j.bbih.2024.100866_bib8 article-title: The role of the kynurenine pathway in suicidality in adolescent major depressive disorder publication-title: Psychiatr. Res. doi: 10.1016/j.psychres.2015.03.031 contributor: fullname: Bradley – volume: 29 start-page: 351 year: 2003 ident: 10.1016/j.bbih.2024.100866_bib21 article-title: Chemokine-dependent mechanisms of leukocyte trafficking across a model of the blood–brain barrier publication-title: Methods doi: 10.1016/S1046-2023(02)00359-6 contributor: fullname: Eugenin – volume: 42 start-page: 145 year: 2008 ident: 10.1016/j.bbih.2024.100866_bib45 article-title: LPS/TLR4 signal transduction pathway publication-title: Cytokine doi: 10.1016/j.cyto.2008.01.006 contributor: fullname: Lu – volume: 63 start-page: 296 year: 2016 ident: 10.1016/j.bbih.2024.100866_bib29 article-title: The role of cytokines in the pathophysiology of suicidal behavior publication-title: Psychoneuroendocrinology doi: 10.1016/j.psyneuen.2015.10.008 contributor: fullname: Ganança – volume: 46 start-page: 225 year: 2016 ident: 10.1016/j.bbih.2024.100866_bib67 article-title: Self-injurious thoughts and behaviors as risk factors for future suicide ideation, attempts, and death: a meta-analysis of longitudinal studies publication-title: Psychol. Med. doi: 10.1017/S0033291715001804 contributor: fullname: Ribeiro – volume: 10 start-page: 1 year: 2020 ident: 10.1016/j.bbih.2024.100866_bib73 article-title: Basal and LPS-stimulated inflammatory markers and the course of individual symptoms of depression publication-title: Transl. Psychiatry doi: 10.1038/s41398-020-00920-4 contributor: fullname: van Eeden – volume: 6 start-page: 327 year: 2019 ident: 10.1016/j.bbih.2024.100866_bib48 article-title: Predictors of future suicide attempt among adolescents with suicidal thoughts or non-suicidal self-harm: a population-based birth cohort study publication-title: Lancet Psychiatr. doi: 10.1016/S2215-0366(19)30030-6 contributor: fullname: Mars – volume: 21 start-page: 613 year: 2009 ident: 10.1016/j.bbih.2024.100866_bib13 article-title: Epidemiology of youth suicide and suicidal behavior publication-title: Curr. Opin. Pediatr. doi: 10.1097/MOP.0b013e32833063e1 contributor: fullname: Cash – volume: vol. 63 year: 1991 ident: 10.1016/j.bbih.2024.100866_bib4 article-title: Manual for the Beck scale for suicide ideation contributor: fullname: Beck – volume: 25 start-page: 194 year: 2015 ident: 10.1016/j.bbih.2024.100866_bib27 article-title: Anhedonia, but not irritability, is associated with illness severity outcomes in adolescent major depression publication-title: J. Child Adolesc. Psychopharmacol. doi: 10.1089/cap.2014.0105 contributor: fullname: Gabbay – volume: 172 start-page: 156 year: 2006 ident: 10.1016/j.bbih.2024.100866_bib64 article-title: Th2 cytokine response in Major Depressive Disorder patients before treatment publication-title: J. Neuroimmunol. doi: 10.1016/j.jneuroim.2005.08.014 contributor: fullname: Pavón – volume: 23 start-page: 5 year: 2016 ident: 10.1016/j.bbih.2024.100866_bib49 article-title: What distinguishes suicide attempters from suicide ideators? A meta‐analysis of potential factors publication-title: Clin. Psychol. Sci. Pract. contributor: fullname: May – volume: 16 start-page: 133 year: 2000 ident: 10.1016/j.bbih.2024.100866_bib41 article-title: Stress, depression and the immune system publication-title: Stress Med. doi: 10.1002/(SICI)1099-1700(200004)16:3<133::AID-SMI876>3.0.CO;2-9 contributor: fullname: Leonard – volume: 80 start-page: 374 year: 2019 ident: 10.1016/j.bbih.2024.100866_bib9 article-title: Relationships between neural activation during a reward task and peripheral cytokine levels in youth with diverse psychiatric symptoms publication-title: Brain Behav. Immun. doi: 10.1016/j.bbi.2019.04.014 contributor: fullname: Bradley – start-page: 135 year: 2013 ident: 10.1016/j.bbih.2024.100866_bib77 article-title: Inflammation and depression contributor: fullname: Zunszain – volume: 46 start-page: 203 year: 2015 ident: 10.1016/j.bbih.2024.100866_bib19 article-title: A meta-analysis of cytokines in suicidal behavior publication-title: Brain Behav. Immun. doi: 10.1016/j.bbi.2015.02.004 contributor: fullname: Ducasse – year: 1984 ident: 10.1016/j.bbih.2024.100866_bib65 contributor: fullname: Poznanski – volume: 6 year: 2016 ident: 10.1016/j.bbih.2024.100866_bib12 article-title: The statistical value of raw fluorescence signal in Luminex xMAP based multiplex immunoassays publication-title: Sci. Rep. doi: 10.1038/srep26996 contributor: fullname: Breen – volume: 840 start-page: 139 year: 1998 ident: 10.1016/j.bbih.2024.100866_bib43 article-title: Brain neurotransmission during peripheral inflammationa publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/j.1749-6632.1998.tb09558.x contributor: fullname: Linthorst – volume: 11 year: 2016 ident: 10.1016/j.bbih.2024.100866_bib58 article-title: Diurnal variation of circulating interleukin-6 in humans: a meta-analysis publication-title: PLoS One doi: 10.1371/journal.pone.0165799 contributor: fullname: Nilsonne – volume: 3 year: 2023 ident: 10.1016/j.bbih.2024.100866_bib6 article-title: Autonomic dysregulation and self-injurious thoughts and behaviours in children and young people: a systematic review and meta-analysis publication-title: JCPP Adv doi: 10.1002/jcv2.12148 contributor: fullname: Bellato – volume: 57 start-page: 289 year: 1995 ident: 10.1016/j.bbih.2024.100866_bib7 article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing publication-title: J. R. Stat. Soc. Ser. B Methodol. doi: 10.1111/j.2517-6161.1995.tb02031.x contributor: fullname: Benjamini – volume: 58 start-page: 193 year: 2014 ident: 10.1016/j.bbih.2024.100866_bib18 article-title: Effects of stress on immune function: the good, the bad, and the beautiful publication-title: Immunol. Res. doi: 10.1007/s12026-014-8517-0 contributor: fullname: Dhabhar – volume: 32 start-page: 356 year: 2008 ident: 10.1016/j.bbih.2024.100866_bib37 article-title: Differences in cytokines between non-suicidal patients and suicidal patients in major depression publication-title: Prog. Neuro-Psychopharmacol. Biol. Psychiatry doi: 10.1016/j.pnpbp.2007.08.041 contributor: fullname: Kim – volume: 4 start-page: 152 year: 2013 ident: 10.1016/j.bbih.2024.100866_bib30 article-title: A preliminary study of white matter in adolescent depression: relationships with illness severity, anhedonia, and irritability publication-title: Front. Psychiatr. doi: 10.3389/fpsyt.2013.00152 contributor: fullname: Henderson – volume: 103 start-page: 302 year: 1994 ident: 10.1016/j.bbih.2024.100866_bib42 article-title: Adolescent psychopathology: II. Psychosocial risk factors for depression publication-title: J. Abnorm. Psychol. doi: 10.1037/0021-843X.103.2.302 contributor: fullname: Lewinsohn – volume: 1391 start-page: 20 year: 2017 ident: 10.1016/j.bbih.2024.100866_bib34 article-title: Cortisol dysregulation: the bidirectional link between stress, depression, and type 2 diabetes mellitus publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/nyas.13217 contributor: fullname: Joseph – volume: 43 start-page: 1 year: 2012 ident: 10.1016/j.bbih.2024.100866_bib38 article-title: Associations between plasma cytokines and depressive mood in patients with breast cancer publication-title: Int. J. Psychiatr. Med. doi: 10.2190/PM.43.1.a contributor: fullname: Kim – volume: 106 start-page: 89 year: 2022 ident: 10.1016/j.bbih.2024.100866_bib57 article-title: Clenbuterol attenuates immune reaction to lipopolysaccharide and its relationship to anhedonia in adolescents publication-title: Brain Behav. Immun. doi: 10.1016/j.bbi.2022.07.163 contributor: fullname: Nguyen – volume: 71 start-page: 188 year: 2015 ident: 10.1016/j.bbih.2024.100866_bib11 article-title: Bead-based multiplex immuno-assays for cytokines, chemokines, growth factors and other analytes: median fluorescence intensities versus their derived absolute concentration values for statistical analysis publication-title: Cytokine doi: 10.1016/j.cyto.2014.10.030 contributor: fullname: Breen – volume: 9 start-page: 46 year: 2008 ident: 10.1016/j.bbih.2024.100866_bib17 article-title: From inflammation to sickness and depression: when the immune system subjugates the brain publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn2297 contributor: fullname: Dantzer – volume: 12 year: 2021 ident: 10.1016/j.bbih.2024.100866_bib20 article-title: Multimodal investigations of reward circuitry and anhedonia in adolescent depression publication-title: Front. Psychiatr. doi: 10.3389/fpsyt.2021.678709 contributor: fullname: Ely – volume: 338 start-page: 171 year: 1998 ident: 10.1016/j.bbih.2024.100866_bib50 article-title: Protective and Damaging effects of stress mediators publication-title: N. Engl. J. Med. doi: 10.1056/NEJM199801153380307 contributor: fullname: McEwen – volume: 20 start-page: 712 year: 2019 ident: 10.1016/j.bbih.2024.100866_bib22 article-title: Anhedonia as a clinical correlate of inflammation in adolescents across psychiatric conditions publication-title: World J. Biol. Psychiatr. doi: 10.1080/15622975.2018.1482000 contributor: fullname: Freed – volume: 21 start-page: 139 year: 2020 ident: 10.1016/j.bbih.2024.100866_bib53 article-title: Cytokine-mediated cellular immune activation in electroconvulsive therapy: a CSF study in patients with treatment-resistant depression publication-title: World J. Biol. Psychiatr. doi: 10.1080/15622975.2019.1618494 contributor: fullname: Mindt – volume: 36 start-page: 39 year: 2020 ident: 10.1016/j.bbih.2024.100866_bib75 article-title: Cytokine changes in different types of depression: specific or general? publication-title: Neurol. Psychiatr. Brain Res. doi: 10.1016/j.npbr.2020.02.009 contributor: fullname: Wang – year: 2023 ident: 10.1016/j.bbih.2024.100866_bib15 article-title: Interpersonal life stress and inflammatory reactivity as prospective predictors of suicide attempts in adolescent females publication-title: Res. Child Adolesc. Psychopathol. doi: 10.1007/s10802-023-01033-4 contributor: fullname: Clayton – volume: 45 start-page: 1808 year: 2015 ident: 10.1016/j.bbih.2024.100866_bib74 article-title: GM-CSF promotes migration of human monocytes across the blood brain barrier: molecular immunology publication-title: Eur. J. Immunol. doi: 10.1002/eji.201444960 contributor: fullname: Vogel – volume: 18 start-page: 174 year: 2016 ident: 10.1016/j.bbih.2024.100866_bib28 article-title: Circadian variations in clinical symptoms and concentrations of inflammatory cytokines, melatonin, and cortisol in polymyalgia rheumatica before and during prednisolone treatment: a controlled, observational, clinical experimental study publication-title: Arthritis Res. Ther. doi: 10.1186/s13075-016-1072-4 contributor: fullname: Galbo – volume: 19 start-page: 298 year: 2022 ident: 10.1016/j.bbih.2024.100866_bib44 article-title: Impact of disease-modifying therapy on dendritic cells and exploring their immunotherapeutic potential in multiple sclerosis publication-title: J. Neuroinflammation doi: 10.1186/s12974-022-02663-z contributor: fullname: Liu – volume: 25 start-page: 335 year: 2011 ident: 10.1016/j.bbih.2024.100866_bib33 article-title: Cytokine levels in the blood may distinguish suicide attempters from depressed patients publication-title: Brain Behav. Immun. doi: 10.1016/j.bbi.2010.10.010 contributor: fullname: Janelidze – volume: 13 year: 2023 ident: 10.1016/j.bbih.2024.100866_bib40 article-title: GM-CSF, Flt3-L and IL-4 affect viability and function of conventional dendritic cell types 1 and 2 publication-title: Front. Immunol. doi: 10.3389/fimmu.2022.1058963 contributor: fullname: Lellahi – volume: 18 start-page: 381 year: 2001 ident: 10.1016/j.bbih.2024.100866_bib10 article-title: The FLT3 tyrosine kinase receptor inhibits neural stem/progenitor cell proliferation and collaborates with NGF to promote neuronal survival publication-title: Mol. Cell. Neurosci. doi: 10.1006/mcne.2001.1033 contributor: fullname: Brazel – volume: 7 year: 2013 ident: 10.1016/j.bbih.2024.100866_bib3 article-title: Interplay between pro-inflammatory cytokines and growth factors in depressive illnesses publication-title: Front. Cell. Neurosci. doi: 10.3389/fncel.2013.00068 contributor: fullname: Audet – volume: 15 start-page: 425 year: 2019 ident: 10.1016/j.bbih.2024.100866_bib51 article-title: Adolescent suicide as a failure of acute stress-response systems publication-title: Annu. Rev. Clin. Psychol. doi: 10.1146/annurev-clinpsy-050718-095625 contributor: fullname: Miller – volume: 53 start-page: 339 year: 1996 ident: 10.1016/j.bbih.2024.100866_bib69 article-title: Psychiatric diagnosis in child and adolescent suicide publication-title: Arch. Gen. Psychiatr. doi: 10.1001/archpsyc.1996.01830040075012 contributor: fullname: Shaffer – volume: 23 start-page: 785 year: 2022 ident: 10.1016/j.bbih.2024.100866_bib2 article-title: Pre-treatment plasma cytokine levels as potential predictors of short-term remission of depression publication-title: World J. Biol. Psychiatr. doi: 10.1080/15622975.2022.2045354 contributor: fullname: Atake – volume: 51 start-page: 935 year: 2010 ident: 10.1016/j.bbih.2024.100866_bib25 article-title: The possible role of the kynurenine pathway in adolescent depression with melancholic features publication-title: JCPP (J. Child Psychol. Psychiatry) doi: 10.1111/j.1469-7610.2010.02245.x contributor: fullname: Gabbay – volume: 10 year: 2019 ident: 10.1016/j.bbih.2024.100866_bib31 article-title: Cytokine research in depression: principles, challenges, and open questions publication-title: Front. Psychiatr. doi: 10.3389/fpsyt.2019.00030 contributor: fullname: Himmerich – volume: 68 start-page: 316 year: 2015 ident: 10.1016/j.bbih.2024.100866_bib66 article-title: Kynurenine pathway dysfunction in the pathophysiology and treatment of depression: evidences from animal and human studies publication-title: J. Psychiatr. Res. doi: 10.1016/j.jpsychires.2015.05.007 contributor: fullname: Réus – year: 1987 ident: 10.1016/j.bbih.2024.100866_bib5 contributor: fullname: Beck – volume: 27 start-page: 3328 year: 2007 ident: 10.1016/j.bbih.2024.100866_bib55 article-title: Involvement of interferon-γ in microglial-mediated loss of dopaminergic neurons publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.5321-06.2007 contributor: fullname: Mount – volume: 73 start-page: 114 year: 2011 ident: 10.1016/j.bbih.2024.100866_bib72 article-title: Depression and hypothalamic-pituitary-adrenal activation: a quantitative summary of four decades of research publication-title: Psychosom. Med. doi: 10.1097/PSY.0b013e31820ad12b contributor: fullname: Stetler – volume: 115 start-page: 177 year: 2009 ident: 10.1016/j.bbih.2024.100866_bib24 article-title: Immune system dysregulation in adolescent major depressive disorder publication-title: J. Affect. Disord. doi: 10.1016/j.jad.2008.07.022 contributor: fullname: Gabbay |
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| Snippet | Suicide is a leading cause of death in adolescents and young adults globally. Well-established risk factors for suicide are depression and past suicide... • Peripheral immune function may be distinctly altered in adolescent suicidality. • Suppressed cytokines (incl. Flt-3L, GM-CSF, and IFN-γ) after an... Background: Suicide is a leading cause of death in adolescents and young adults globally. Well-established risk factors for suicide are depression and past... |
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| Title | Immunological correlates of suicidality among adolescents with internalizing symptoms |
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