Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins

We have analyzed T cell receptor repertoires in a unique set of thymus samples from a pair of monozygotic twins. While genetics affect the V(D)J rearrangement and generation of junctional sequences, the thymic selections seem largely stochastic and import no detectable inheritable effect at clonal l...

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Bibliographic Details
Published in:	European journal of immunology Vol. 50; no. 5; pp. 748 - 751
Main Authors:	Heikkilä, Nelli, Vanhanen, Reetta, Yohannes, Dawit A., Saavalainen, Päivi, Meri, Seppo, Jokiranta, T. Sakari, Jarva, Hanna, Mattila, Ilkka P., Hamm, David, Sormunen, Silja, Saramäki, Jari, Arstila, T. Petteri
Format:	Journal Article
Language:	English
Published:	Germany Wiley Subscription Services, Inc 01-05-2020
Subjects:	CDR3 genetics Lymphocytes T Stochasticity T cell receptors TCR repertoire thymic selection Thymus Twins thymic selection twins genetics CDR3 TCR repertoire
Online Access:	Get full text
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Summary:	We have analyzed T cell receptor repertoires in a unique set of thymus samples from a pair of monozygotic twins. While genetics affect the V(D)J rearrangement and generation of junctional sequences, the thymic selections seem largely stochastic and import no detectable inheritable effect at clonal level.
Bibliography:	https://publons.com/publon/10.1002/eji.201948404 The peer review history for this article is available at SourceType-Other Sources-1 ObjectType-Article-2 content type line 63 ObjectType-Correspondence-1
ISSN:	0014-2980 1521-4141
DOI:	10.1002/eji.201948404