Bioconcentration and acute toxicity of polycyclic musks in two benthic organisms (Chironomus riparius and Lumbriculus variegatus)

• Published in: Environmental toxicology and chemistry Vol. 22; no. 5; pp. 1086 - 1092
• Main Authors: Artola-Garicano, Elsa, Sinnige, Theo L., van Holsteijn, Ineke, Vaes, Wouter H. J., Hermens, Joop L. M.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Periodicals, Inc 01-05-2003; SETAC
• Subjects: Acute toxicity; Animal, plant and microbial ecology; Animals; Applied ecology; Benthic organisms; Benzopyrans - chemistry; Benzopyrans - metabolism; Benzopyrans - toxicity; Bioconcentration; Biological and medical sciences; Biotransformation; Chironomidae; Chironomidae - drug effects; Chironomidae - metabolism; Chironomus riparius; Cytochrome P-450 Enzyme Inhibitors; Ecotoxicology, biological effects of pollution; Effects of pollution and side effects of pesticides on protozoa and invertebrates; Environmental Exposure - analysis; Fundamental and applied biological sciences. Psychology; Kinetics; Larva - drug effects; Larva - metabolism; Lipids - analysis; Lumbriculus variegatus; Naphthalenes - chemistry; Naphthalenes - metabolism; Naphthalenes - toxicity; Oligochaeta; Oligochaeta - drug effects; Oligochaeta - metabolism; Perfume - analysis; Piperonyl Butoxide - pharmacology; Polycyclic musks; Predictive Value of Tests; Solubility; Techniques; Tetrahydronaphthalenes; Toxicity Tests, Acute; Chironomidae; Benthic organism; Ecotoxicology; Chironomus riparius; Musk; Toxicity; Insecta; Perfume; Acute; Interspecific comparison; Polycyclic compound; Toxicity test; Risk analysis; Annelida; Oligochaeta; Freshwater environment; Arthropoda; Bioconcentration Acute toxicity Benthic organisms Polycyclic musks; Concentration effect; Water pollution; Invertebrata; Biological accumulation; Diptera
• ISSN: 0730-7268; 1552-8618
• DOI: 10.1002/etc.5620220516

In the current study, the bioconcentration behavior and acute toxicity of two polycyclic musks, Tonalide® 7‐acetyl‐1,1,3,4,4,6,‐hexamethyl‐1,2,3,4,‐tetrahydronaphthalene (AHTN) and Galaxolide® 1,3,4,6,7,8‐hexahydro‐4,6,6,7,8,8‐hexa‐methyl‐cyclopenta[γ]‐2‐benzopyran (HHCB), were studied in two benthic organisms. Polycyclic musks are frequently used fragrances, and they have been detected in different compartments of the environment. The aim of this study was to fill some empirical data gaps for AHTN and HHCB for benthic organisms. Results show that differences exist between both organisms. Chironomus riparius exhibited bioconcentration factors (BCFs) for AHTN and HHCB substantially lower than predicted for nontransformed organics. The BCFs for both chemicals increased after coexposure of the organism to the cytochrome P450 inhibitor piperonyl butoxide. Thus, the low BCF values were the result of rapid biotransformation of AHTN and HHCB in the midge larvae. Bioconcentration kinetics indicated that both chemicals induced their own cytochrome P450–mediated metabolism. Acute toxicity of AHTN to midge larvae was reduced compared to predicted baseline toxicity and was similar for HHCB. Bioconcentration of AHTN and HHCB in the worm (Lumbriculus variegatus) is in agreement with predictions based on the octanol‐water partition coefficients of these chemicals. Acute toxicity was found to be similar to predicted values for baseline toxicity. Summarizing, for AHTN and HHCB, acute toxicity and bioconcentration behavior in L. variegatus was in accordance with predicted data for nontransformed organics. In C. riparius, bioconcentration as well as toxicity were reduced.