Whipple's disease confined to the central nervous system

Progressive hypersomnia, memory disturbance, and vertical ophthalmoplegia developed in a 63-year-old woman. The diagnosis of Whipple's disease of the central nervous system was suggested by her presentation and results of studies using magnetic resonance imaging. Despite a one-month course of a...

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Bibliographic Details
Published in:	Annals of neurology Vol. 21; no. 1; p. 104
Main Authors:	Adams, M, Rhyner, P A, Day, J, DeArmond, S, Smuckler, E A
Format:	Journal Article
Language:	English
Published:	United States 01-01-1987
Subjects:	Anti-Infective Agents - therapeutic use Brain - pathology Central Nervous System Diseases - diagnosis Central Nervous System Diseases - drug therapy Central Nervous System Diseases - pathology Female Humans Microscopy, Electron Middle Aged Whipple Disease - diagnosis Whipple Disease - drug therapy Whipple Disease - pathology
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Summary:	Progressive hypersomnia, memory disturbance, and vertical ophthalmoplegia developed in a 63-year-old woman. The diagnosis of Whipple's disease of the central nervous system was suggested by her presentation and results of studies using magnetic resonance imaging. Despite a one-month course of antibiotics, active Whipple's disease, localized to the central nervous system, was found at autopsy.
ISSN:	0364-5134
DOI:	10.1002/ana.410210121