$Figitumumab in patients with refractory metastatic colorectal cancer previously treated with standard therapies: a nonrandomized, open-label, phase II trial$
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Figitumumab in patients with refractory metastatic colorectal cancer previously treated with standard therapies: a nonrandomized, open-label, phase II trial

Purpose Figitumumab (CP-751,871) is a human IgG2 monoclonal antibody that binds and down-regulates insulin-like growth factor receptor-1 (IGF-1R) and inhibits activation of this receptor by IGF-1 and IGF-2. This nonrandomized, open-label, single-arm, phase II trial evaluated the antitumor activity a...

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Bibliographic Details
Published in:	Cancer chemotherapy and pharmacology Vol. 73; no. 4; pp. 695 - 702
Main Authors:	Becerra, Carlos R., Salazar, Ramon, Garcia-Carbonero, Rocio, Thomas, Anne L., Vázquez-Mazón, Federico J., Cassidy, James, Maughan, Tim, Castillo, Manuel Gallén, Iveson, Tim, Yin, Donghua, Green, Stephanie, Bergsland, Emily K.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-04-2014 Springer Springer Nature B.V
Subjects:	Adult Aged Aged, 80 and over Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal - therapeutic use Antineoplastic agents Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Biological and medical sciences Cancer Research Cohort Studies Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Female Gastroenterology. Liver. Pancreas. Abdomen Humans Male Medical sciences Medicine Medicine & Public Health Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Metastasis Neoplasm Staging Oncology Original Article Pharmacology. Drug treatments Pharmacology/Toxicology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Analysis Tumors Phase II Safety Figitumumab Metastatic colorectal cancer Antineoplastic agent Human Treatment resistance Rectal disease Toxicity Colorectal cancer Monoclonal antibody Malignant tumor Metastasis Standards Colonic disease Treatment Phase II trial Digestive diseases Intestinal disease Advanced stage Cancer
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