Effect of N-Acetylcysteine and Fructose-1,6-Bisphosphate in the Treatment of Experimental Sepsis

• Published in: Inflammation Vol. 34; no. 6; pp. 539 - 550
• Main Authors: de Mello, Ricardo Obalski, Lunardelli, Adroaldo, Caberlon, Eduardo, de Moraes, Cristina Machado Bragança, Christ Vianna Santos, Roberto, da Costa, Vinicius Lorini, da Silva, Gabriela Viegas, da Silva Scherer, Patrícia, Buaes, Luiz Eduardo Coimbra, da Silva Melo, Denizar Alberto, Donadio, Márcio Vinícius Fagundes, Nunes, Fernanda Bordignon, de Oliveira, Jarbas Rodrigues
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01-12-2011; Springer Nature B.V
• Subjects: Acetylcysteine - pharmacology; Acetylcysteine - therapeutic use; Animals; Biomedical and Life Sciences; Biomedicine; Drug Synergism; Drug Therapy, Combination; Escherichia coli; Fructose-Bisphosphatase - pharmacology; Fructose-Bisphosphatase - therapeutic use; Immunology; Internal Medicine; Pathology; Pharmacology/Toxicology; Rats; Rheumatology; Sepsis - drug therapy; Sepsis - mortality; Survival Rate; Treatment Outcome; fructose-1,6-bisphosphate; sepsis; oxidative stress; N-acetylcysteine
• ISSN: 0360-3997; 1573-2576
• DOI: 10.1007/s10753-010-9261-9

Sepsis is a syndrome caused by uncontrolled systemic inflammatory response of the individual, which represents a serious epidemiological problem worldwide. The aim of this study was to investigate the effect of N-acetylcysteine (NAC) and fructose-1,6-bisphosphate (FBP) in the treatment of experimental sepsis. We used rats that were divided into five experimental groups: normal control (not induced), septic control (induced using a capsule with non sterile fecal content and
Escherichia coli
), treated with FBP (500 mg/kg i.p.), treated with NAC (150 mg/kg i.p.), and treated with the combination of FBP with NAC. In the group treated with NAC, 16.68% of the mice survived, the FBP reduced the mortality of mice during the acute stage of the disease and increased the animals’ survival time in 33.34%, and the combination of drugs had no effect. Our results show that NAC prevented the mortality of animals after septic induction. These data confirm the validity of the use of NAC in the treatment of sepsis. Our data also show that the synergistic action with FBP does not improve the picture.