Cardiometabolic phenotypes and mitochondrial DNA copy number in two cohorts of UK women
The mitochondrial genome is present at variable copy number between individuals. Mitochondria are vulnerable to oxidative stress, and their dysfunction may be associated with cardiovascular disease. The association of mitochondrial DNA copy number with cardiometabolic risk factors (lipids, glycaemic...
Saved in:
| Published in: | Mitochondrion Vol. 39; pp. 9 - 19 |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Netherlands
Elsevier Science
01-03-2018
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | The mitochondrial genome is present at variable copy number between individuals. Mitochondria are vulnerable to oxidative stress, and their dysfunction may be associated with cardiovascular disease. The association of mitochondrial DNA copy number with cardiometabolic risk factors (lipids, glycaemic traits, inflammatory markers, anthropometry and blood pressure) was assessed in two independent cohorts of European origin women, one in whom outcomes were measured at mean (SD) age 30 (4.3) years (N=2278) and the second at 69.4 (5.5) years (N=2872). Mitochondrial DNA copy number was assayed by quantitative polymerase chain reaction. Associations were adjusted for smoking, sociodemographic status, laboratory factors and white cell traits. Out of a total of 12 outcomes assessed in both cohorts, mitochondrial DNA copy number showed little or no association with the majority (point estimates were close to zero and nearly all p-values were >0.01). The strongest evidence was for an inverse association in the older cohort with insulin (standardised beta [95%CI]: -0.06, [-0.098, -0.022], p=0.002), but this association did not replicate in the younger cohort. Our findings do not provide support for variation in mitochondrial DNA copy number having an important impact on cardio-metabolic risk factors in European origin women. |
|---|---|
| AbstractList | The mitochondrial genome is present at variable copy number between individuals. Mitochondria are vulnerable to oxidative stress, and their dysfunction may be associated with cardiovascular disease.
The association of mitochondrial DNA copy number with cardiometabolic risk factors (lipids, glycaemic traits, inflammatory markers, anthropometry and blood pressure) was assessed in two independent cohorts of European origin women, one in whom outcomes were measured at mean (SD) age 30 (4.3) years (
N
= 2278) and the second at 69.4 (5.5) years (
N
= 2872). Mitochondrial DNA copy number was assayed by quantitative polymerase chain reaction. Associations were adjusted for smoking, sociodemographic status, laboratory factors and white cell traits.
Out of a total of 12 outcomes assessed in both cohorts, mitochondrial DNA copy number showed little or no association with the majority (point estimates were close to zero and nearly all
p
-values were > 0.01). The strongest evidence was for an inverse association in the older cohort with insulin (standardised beta [95%CI]: − 0.06, [− 0.098, − 0.022],
p
= 0.002), but this association did not replicate in the younger cohort.
Our findings do not provide support for variation in mitochondrial DNA copy number having an important impact on cardio-metabolic risk factors in European origin women.
•
MtDNA copy number was studied in relation to cardiometabolic traits in two cohorts of women.
•
Associations were adjusted for a number of possible confounders.
•
There was weak evidence for an inverse relationship between mtDNA copy number and insulin in the older cohort.
•
The findings do not suggest an important association between mtDNA copy number and the majority of phenotypes studied. The mitochondrial genome is present at variable copy number between individuals. Mitochondria are vulnerable to oxidative stress, and their dysfunction may be associated with cardiovascular disease. The association of mitochondrial DNA copy number with cardiometabolic risk factors (lipids, glycaemic traits, inflammatory markers, anthropometry and blood pressure) was assessed in two independent cohorts of European origin women, one in whom outcomes were measured at mean (SD) age 30 (4.3) years (N=2278) and the second at 69.4 (5.5) years (N=2872). Mitochondrial DNA copy number was assayed by quantitative polymerase chain reaction. Associations were adjusted for smoking, sociodemographic status, laboratory factors and white cell traits. Out of a total of 12 outcomes assessed in both cohorts, mitochondrial DNA copy number showed little or no association with the majority (point estimates were close to zero and nearly all p-values were >0.01). The strongest evidence was for an inverse association in the older cohort with insulin (standardised beta [95%CI]: -0.06, [-0.098, -0.022], p=0.002), but this association did not replicate in the younger cohort. Our findings do not provide support for variation in mitochondrial DNA copy number having an important impact on cardio-metabolic risk factors in European origin women. |
| Author | Burrows, Kimberley Day, Ian N M Gaunt, Tom R Rodriguez, Santiago Guyatt, Anna L Guthrie, Philip A I McArdle, Wendy Ascione, Raimondo Ring, Sue Lawlor, Debbie A |
| AuthorAffiliation | c Bristol Heart Institute, School of Clinical Sciences, University of Bristol, Bristol, UK a MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK b School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK |
| AuthorAffiliation_xml | – name: a MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK – name: b School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK – name: c Bristol Heart Institute, School of Clinical Sciences, University of Bristol, Bristol, UK |
| Author_xml | – sequence: 1 givenname: Anna L surname: Guyatt fullname: Guyatt, Anna L organization: MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK; School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK – sequence: 2 givenname: Kimberley surname: Burrows fullname: Burrows, Kimberley organization: MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK; School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK – sequence: 3 givenname: Philip A I surname: Guthrie fullname: Guthrie, Philip A I organization: School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK – sequence: 4 givenname: Sue surname: Ring fullname: Ring, Sue organization: MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK; School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK – sequence: 5 givenname: Wendy surname: McArdle fullname: McArdle, Wendy organization: MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK; School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK – sequence: 6 givenname: Ian N M surname: Day fullname: Day, Ian N M organization: School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK – sequence: 7 givenname: Raimondo surname: Ascione fullname: Ascione, Raimondo organization: Bristol Heart Institute, School of Clinical Sciences, University of Bristol, Bristol, UK – sequence: 8 givenname: Debbie A surname: Lawlor fullname: Lawlor, Debbie A organization: MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK; School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK – sequence: 9 givenname: Tom R surname: Gaunt fullname: Gaunt, Tom R organization: MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK; School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK – sequence: 10 givenname: Santiago surname: Rodriguez fullname: Rodriguez, Santiago email: santi.rodriguez@bristol.ac.uk organization: MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK; School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK. Electronic address: santi.rodriguez@bristol.ac.uk |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28818596$$D View this record in MEDLINE/PubMed |
| BookMark | eNpVUUtPxCAQJkbjrqt_wIPh6KUVKBS4mGzWZzR60XgktFCXTQsVupr993bjI3qaycz3mMx3AHZ98BaAY4xyjHB5tso7N4ScIMxzJHKE-A6YYsFJJggXu2PPSp5xQuUEHKS0QiMQE7IPJkQILJgsp-BloaNxobODrkLratgvrQ_DprcJam_g1qFeBm-i0y28eJjDOvQb6NddZSN0Hg4fYRwtQxwSDA18voMfo5o_BHuNbpM9-q4z8Hx1-bS4ye4fr28X8_uspogMma40MQ1jsjKcSlMxKXTDKaowZwxrihtUElahgnBbClbURnJiaSMEociUtJiB8y_dfl111tTWD1G3qo-u03Gjgnbq_8a7pXoN74qJgkjBR4HTb4EY3tY2DapzqbZtq70N66SwLBAVBedyhJIvaB1DStE2vzYYqW0iaqW2_1LbRBQSakxkJJ38PfCX8hNB8QmmHYuf |
| CitedBy_id | crossref_primary_10_1016_j_xgen_2021_100006 crossref_primary_10_1007_s11033_024_09616_0 crossref_primary_10_1007_s13167_022_00281_6 crossref_primary_10_1093_jn_nxaa146 crossref_primary_10_1186_s40246_021_00335_2 crossref_primary_10_1016_j_chemosphere_2021_129907 crossref_primary_10_1080_24701394_2018_1544248 crossref_primary_10_1111_joim_13242 crossref_primary_10_1016_j_mito_2020_07_004 crossref_primary_10_3389_fpubh_2022_904856 |
| Cites_doi | 10.1681/ASN.2015060661 10.1016/j.exger.2006.03.014 10.1371/journal.pgen.1004369 10.1016/j.cca.2010.01.024 10.1258/acb.2008.008008 10.1002/jcp.1041360316 10.1038/nature09787 10.1016/S1474-4422(10)70083-1 10.1093/ije/dys066 10.1016/j.bbrc.2011.06.067 10.1007/BF03324472 10.1186/1471-2350-10-35 10.1196/annals.1338.008 10.4238/2012.September.17.4 10.1016/j.neulet.2013.10.045 10.1016/0921-8734(92)90021-G 10.1007/s00134-010-1823-7 10.3233/JAD-131715 10.1038/sj.cdd.4401320 10.1073/pnas.0403649101 10.1016/j.mrfmmm.2004.10.003 10.1007/s11695-009-9987-3 10.1111/acel.12287 10.1186/gb-2014-15-2-r31 10.7754/Clin.Lab.2014.140313 10.1016/j.neurobiolaging.2015.10.033 10.1093/hmg/ddu739 10.1007/s00125-007-0818-6 10.1136/jech.2004.029991 10.1016/0006-291X(92)90517-O 10.1093/nar/18.23.6927 10.1007/s10545-011-9382-9 10.1186/1471-2105-13-86 10.1097/gme.0b013e31823a3e46 10.3168/jds.2015-9847 10.1002/ana.23955 10.1016/j.cca.2013.06.006 10.1161/CIRCRESAHA.111.246868 10.1371/journal.pone.0043149 10.1097/gme.0b013e3182503e97 10.1136/jmg.2007.048876 10.1111/pcn.12163 10.1016/j.diabres.2008.10.002 10.1097/QAD.0b013e32833f9d02 10.5551/jat.8698 10.1038/nrm3352 10.1136/jech.57.2.134 10.1007/s13311-013-0177-6 10.1016/j.bbagen.2011.08.008 10.1172/JCI117790 10.1007/s00109-014-1233-3 10.1016/j.pnpbp.2013.09.002 10.1016/j.pnpbp.2015.06.012 10.1007/s00439-014-1458-9 10.1093/ije/dyv072 10.1182/blood-2013-10-532085 10.1016/j.archger.2010.11.019 10.1016/j.diabres.2009.07.002 10.1016/j.atherosclerosis.2014.08.051 10.2337/db05-1230 10.1073/pnas.0501559102 10.1136/bmj.327.7414.557 10.1111/j.1469-1809.2011.00654.x 10.1080/07853890510007368 10.1086/502682 10.1016/j.taap.2006.01.003 10.1016/j.diabres.2011.01.010 10.1086/383251 |
| ContentType | Journal Article |
| Copyright | Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved. 2017 The Authors 2017 |
| Copyright_xml | – notice: Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved. – notice: 2017 The Authors 2017 |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 5PM |
| DOI | 10.1016/j.mito.2017.08.007 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1872-8278 |
| EndPage | 19 |
| ExternalDocumentID | 10_1016_j_mito_2017_08_007 28818596 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | United Kingdom |
| GeographicLocations_xml | – name: United Kingdom |
| GrantInformation_xml | – fundername: Wellcome Trust – fundername: Medical Research Council grantid: MC_UU_12013/5 – fundername: Medical Research Council grantid: MC_UU_00011/4 – fundername: Wellcome Trust grantid: 102215/2/13/2 – fundername: British Heart Foundation grantid: PG/16/104/32652 – fundername: Medical Research Council grantid: MC_PC_15018 – fundername: British Heart Foundation grantid: PG/13/66/30442 – fundername: Medical Research Council grantid: MR/K002767/1 – fundername: Medical Research Council grantid: G9815508 – fundername: Wellcome Trust grantid: 102433/Z/13/Z |
| GroupedDBID | --- --K --M .~1 0R~ 123 1B1 1RT 1~. 1~5 29M 4.4 457 4G. 53G 5VS 7-5 71M 8P~ AACTN AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAXKI AAXUO ABFNM ABFRF ABGSF ABJNI ABMAC ABUDA ABXDB ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADUVX AEBSH AEFWE AEHWI AEKER AENEX AFJKZ AFKWA AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AIEXJ AIKHN AITUG AJOXV AKRWK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CGR CS3 CUY CVF DU5 EBS ECM EFJIC EIF EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-Q GBLVA HVGLF HZ~ IHE J1W KOM M41 MO0 N9A NPM O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SDF SDG SES SEW SPCBC SSU SSZ T5K UHS UNMZH ~G- AAYXX CITATION 7X8 5PM |
| ID | FETCH-LOGICAL-c402t-aba2df559bd749db598af740b17551a41f0625b0327e6853cd972e4f88240d643 |
| ISSN | 1567-7249 |
| IngestDate | Tue Sep 17 21:25:21 EDT 2024 Sat Oct 26 05:57:24 EDT 2024 Thu Sep 26 16:47:55 EDT 2024 Sat Nov 02 12:25:21 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Cardiovascular disease ALSPAC Mitochondrial DNA Diabetes Copy number Complex traits |
| Language | English |
| License | Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c402t-aba2df559bd749db598af740b17551a41f0625b0327e6853cd972e4f88240d643 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work. |
| OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC5832987 |
| PMID | 28818596 |
| PQID | 1930483779 |
| PQPubID | 23479 |
| PageCount | 11 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_5832987 proquest_miscellaneous_1930483779 crossref_primary_10_1016_j_mito_2017_08_007 pubmed_primary_28818596 |
| PublicationCentury | 2000 |
| PublicationDate | 2018-03-00 20180301 |
| PublicationDateYYYYMMDD | 2018-03-01 |
| PublicationDate_xml | – month: 03 year: 2018 text: 2018-03-00 |
| PublicationDecade | 2010 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Mitochondrion |
| PublicationTitleAlternate | Mitochondrion |
| PublicationYear | 2018 |
| Publisher | Elsevier Science |
| Publisher_xml | – name: Elsevier Science |
| References | Liu (10.1016/j.mito.2017.08.007_bb0240) 2005; 1042 Rolo (10.1016/j.mito.2017.08.007_bb0350) 2006; 212 Samuels (10.1016/j.mito.2017.08.007_bb0365) 2006; 78 10.1016/j.mito.2017.08.007_bb0160 Hosnijeh (10.1016/j.mito.2017.08.007_bb0125) 2014; 124 Rice (10.1016/j.mito.2017.08.007_bb0335) 2014; 40 Kim (10.1016/j.mito.2017.08.007_bb0195) 2013; 8 Zabaneh (10.1016/j.mito.2017.08.007_bb0405) 2011; 75 Arai (10.1016/j.mito.2017.08.007_bb0010) 2003; 15 Lawlor (10.1016/j.mito.2017.08.007_bb0220) 2005; 59 Botto (10.1016/j.mito.2017.08.007_bb0030) 2005; 570 Chinnery (10.1016/j.mito.2017.08.007_bb0065) 2010; 9 Laubenthal (10.1016/j.mito.2017.08.007_bb0210) 2016; 99 Ziegler (10.1016/j.mito.2017.08.007_bb0415) 2015; 14 Malik (10.1016/j.mito.2017.08.007_bb0250) 2009; 86 Mengel-From (10.1016/j.mito.2017.08.007_bb0265) 2014; 133 Bersani (10.1016/j.mito.2017.08.007_bb0025) 2016; 64 Weng (10.1016/j.mito.2017.08.007_bb0390) 2009; 83 Knez (10.1016/j.mito.2017.08.007_bb0200) 2016; 183 Ding (10.1016/j.mito.2017.08.007_bb0100) 2015; 11 Mohamed (10.1016/j.mito.2017.08.007_bb0270) 2006; 41 Asmann (10.1016/j.mito.2017.08.007_bb0020) 2006; 55 Jonckheere (10.1016/j.mito.2017.08.007_bb0170) 2012; 35 Moslehi (10.1016/j.mito.2017.08.007_bb0275) 2012; 110 St John (10.1016/j.mito.2017.08.007_bb0375) 2007; 12 Coskun (10.1016/j.mito.2017.08.007_bb0085) 2012; 1820 Kim (10.1016/j.mito.2017.08.007_bb0185) 2012; 19 Hulgan (10.1016/j.mito.2017.08.007_bb0155) 2011; 25 Kim (10.1016/j.mito.2017.08.007_bb0180) 2011; 53 Rea (10.1016/j.mito.2017.08.007_bb0325) 2013; 35 Short (10.1016/j.mito.2017.08.007_bb0370) 2005; 102 Chang (10.1016/j.mito.2017.08.007_bb0040) 2015; 10 Tin (10.1016/j.mito.2017.08.007_bb0380) 2016 Zabihi Diba (10.1016/j.mito.2017.08.007_bb0410) 2016; 27 Houseman (10.1016/j.mito.2017.08.007_bb0130) 2012; 13 Sahin (10.1016/j.mito.2017.08.007_bb0355) 2012; 13 Wiesner (10.1016/j.mito.2017.08.007_bb0395) 1992; 183 Mozhei (10.1016/j.mito.2017.08.007_bb0280) 2014; 48 Dimauro (10.1016/j.mito.2017.08.007_bb0095) 2005; 37 Corral-Debrinski (10.1016/j.mito.2017.08.007_bb0070) 1992; 275 Malik (10.1016/j.mito.2017.08.007_bb0255) 2011; 412 Gatt (10.1016/j.mito.2017.08.007_bb0115) 2013; 557 Huang (10.1016/j.mito.2017.08.007_bb0140) 2011; 18 10.1016/j.mito.2017.08.007_bb0260 Pyle (10.1016/j.mito.2017.08.007_bb0310) 2010; 36 Pyle (10.1016/j.mito.2017.08.007_bb0315) 2016; 38 Huang (10.1016/j.mito.2017.08.007_bb0145) 2016; 95 Fraser (10.1016/j.mito.2017.08.007_bb0110) 2013; 42 El-Hattab (10.1016/j.mito.2017.08.007_bb0105) 2013; 10 Podlesniy (10.1016/j.mito.2017.08.007_bb0300) 2013; 74 Lee (10.1016/j.mito.2017.08.007_bb0225) 2010; 411 Lindinger (10.1016/j.mito.2017.08.007_bb0235) 2010; 20 Robin (10.1016/j.mito.2017.08.007_bb0345) 1988; 136 Ashar (10.1016/j.mito.2017.08.007_bb0015) 2015; 93 Kim (10.1016/j.mito.2017.08.007_bb0190) 2012; 19 Kofler (10.1016/j.mito.2017.08.007_bb0205) 2009; 10 Maianski (10.1016/j.mito.2017.08.007_bb0245) 2004; 11 Coskun (10.1016/j.mito.2017.08.007_bb0080) 2004; 101 Nardelli (10.1016/j.mito.2017.08.007_bb0285) 2013; 631082 Cortopassi (10.1016/j.mito.2017.08.007_bb0075) 1990; 18 Jaffe (10.1016/j.mito.2017.08.007_bb0165) 2014; 15 Hsieh (10.1016/j.mito.2017.08.007_bb0135) 2011; 92 Lawlor (10.1016/j.mito.2017.08.007_bb0215) 2003; 57 Lee (10.1016/j.mito.2017.08.007_bb0230) 2014; 586017 Yu (10.1016/j.mito.2017.08.007_bb0400) 2013; 424 Higgins (10.1016/j.mito.2017.08.007_bb0120) 2003; 327 Office for National Statistics, E. L (10.1016/j.mito.2017.08.007_bb0295) 2000 Chinnery (10.1016/j.mito.2017.08.007_bb0060) 2007; 44 Hudson (10.1016/j.mito.2017.08.007_bb0150) 2014; 10 Nyholt (10.1016/j.mito.2017.08.007_bb0290) 2004; 74 Relton (10.1016/j.mito.2017.08.007_bb0330) 2015 Antonetti (10.1016/j.mito.2017.08.007_bb0005) 1995; 95 Kaaman (10.1016/j.mito.2017.08.007_bb0175) 2007; 50 Urata (10.1016/j.mito.2017.08.007_bb0385) 2008; 45 10.1016/j.mito.2017.08.007_bb0055 Chen (10.1016/j.mito.2017.08.007_bb0045) 2014; 237 De Sousa (10.1016/j.mito.2017.08.007_bb0090) 2014; 48 Purdue (10.1016/j.mito.2017.08.007_bb0305) 2012; 7 Richmond (10.1016/j.mito.2017.08.007_bb0340) 2015; 24 Sahin (10.1016/j.mito.2017.08.007_bb0360) 2011; 470 Qiu (10.1016/j.mito.2017.08.007_bb0320) 2015; 61 Chang (10.1016/j.mito.2017.08.007_bb0035) 2014; 68 Chien (10.1016/j.mito.2017.08.007_bb0050) 2012; 11 |
| References_xml | – year: 2016 ident: 10.1016/j.mito.2017.08.007_bb0380 article-title: Association between mitochondrial DNA copy number in peripheral blood and incident CKD in the atherosclerosis risk in communities study publication-title: J. Am. Soc. Nephrol. doi: 10.1681/ASN.2015060661 contributor: fullname: Tin – volume: 41 start-page: 508 year: 2006 ident: 10.1016/j.mito.2017.08.007_bb0270 article-title: Mitochondrial DNA deletions and the aging heart publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2006.03.014 contributor: fullname: Mohamed – volume: 10 year: 2014 ident: 10.1016/j.mito.2017.08.007_bb0150 article-title: Recent mitochondrial DNA mutations increase the risk of developing common late-onset human diseases publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1004369 contributor: fullname: Hudson – volume: 411 start-page: 592 year: 2010 ident: 10.1016/j.mito.2017.08.007_bb0225 article-title: Mitochondrial DNA copy number in peripheral blood is associated with cognitive function in apparently healthy elderly women publication-title: Clin. Chim. Acta doi: 10.1016/j.cca.2010.01.024 contributor: fullname: Lee – ident: 10.1016/j.mito.2017.08.007_bb0055 – volume: 45 start-page: 513 year: 2008 ident: 10.1016/j.mito.2017.08.007_bb0385 article-title: Platelet contamination causes large variation as well as overestimation of mitochondrial DNA content of peripheral blood mononuclear cells publication-title: Ann. Clin. Biochem. doi: 10.1258/acb.2008.008008 contributor: fullname: Urata – volume: 136 start-page: 507 year: 1988 ident: 10.1016/j.mito.2017.08.007_bb0345 article-title: Mitochondrial DNA molecules and virtual number of mitochondria per cell in mammalian cells publication-title: J. Cell. Physiol. doi: 10.1002/jcp.1041360316 contributor: fullname: Robin – ident: 10.1016/j.mito.2017.08.007_bb0160 – volume: 470 start-page: 359 year: 2011 ident: 10.1016/j.mito.2017.08.007_bb0360 article-title: Telomere dysfunction induces metabolic and mitochondrial compromise publication-title: Nature doi: 10.1038/nature09787 contributor: fullname: Sahin – volume: 9 start-page: 498 year: 2010 ident: 10.1016/j.mito.2017.08.007_bb0065 article-title: Mitochondrial DNA haplogroups and risk of transient ischaemic attack and ischaemic stroke: a genetic association study publication-title: Lancet Neurol. doi: 10.1016/S1474-4422(10)70083-1 contributor: fullname: Chinnery – volume: 42 start-page: 97 year: 2013 ident: 10.1016/j.mito.2017.08.007_bb0110 article-title: Cohort profile: the Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort publication-title: Int. J. Epidemiol. doi: 10.1093/ije/dys066 contributor: fullname: Fraser – volume: 412 start-page: 1 year: 2011 ident: 10.1016/j.mito.2017.08.007_bb0255 article-title: Mitochondrial DNA as a non-invasive biomarker: accurate quantification using real time quantitative PCR without co-amplification of pseudogenes and dilution bias publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2011.06.067 contributor: fullname: Malik – volume: 15 start-page: 1 year: 2003 ident: 10.1016/j.mito.2017.08.007_bb0010 article-title: Age-related mitochondrial DNA deletion in human heart: its relationship with cardiovascular diseases publication-title: Aging Clin. Exp. Res. doi: 10.1007/BF03324472 contributor: fullname: Arai – volume: 10 start-page: 35 year: 2009 ident: 10.1016/j.mito.2017.08.007_bb0205 article-title: Mitochondrial DNA haplogroup T is associated with coronary artery disease and diabetic retinopathy: a case control study publication-title: BMC Med. Genet. doi: 10.1186/1471-2350-10-35 contributor: fullname: Kofler – volume: 1042 start-page: 70 year: 2005 ident: 10.1016/j.mito.2017.08.007_bb0240 article-title: Alteration of the copy number of mitochondrial DNA in leukocytes of patients with hyperlipidemia publication-title: Ann. N. Y. Acad. Sci. doi: 10.1196/annals.1338.008 contributor: fullname: Liu – volume: 11 start-page: 3339 year: 2012 ident: 10.1016/j.mito.2017.08.007_bb0050 article-title: Role of mitochondrial DNA variants and copy number in diabetic atherogenesis publication-title: Genet. Mol. Res. doi: 10.4238/2012.September.17.4 contributor: fullname: Chien – volume: 557 start-page: 177 issue: Pt B year: 2013 ident: 10.1016/j.mito.2017.08.007_bb0115 article-title: Association of a polymorphism in mitochondrial transcription factor A (TFAM) with Parkinson's disease dementia but not dementia with Lewy bodies publication-title: Neurosci. Lett. doi: 10.1016/j.neulet.2013.10.045 contributor: fullname: Gatt – volume: 275 start-page: 169 year: 1992 ident: 10.1016/j.mito.2017.08.007_bb0070 article-title: Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease publication-title: Mutat. Res. doi: 10.1016/0921-8734(92)90021-G contributor: fullname: Corral-Debrinski – volume: 36 start-page: 956 year: 2010 ident: 10.1016/j.mito.2017.08.007_bb0310 article-title: Fall in circulating mononuclear cell mitochondrial DNA content in human sepsis publication-title: Intensive Care Med. doi: 10.1007/s00134-010-1823-7 contributor: fullname: Pyle – volume: 40 start-page: 319 year: 2014 ident: 10.1016/j.mito.2017.08.007_bb0335 article-title: Mitochondrial DNA copy numbers in pyramidal neurons are decreased and mitochondrial biogenesis transcriptome signaling is disrupted in Alzheimer's disease hippocampi publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-131715 contributor: fullname: Rice – volume: 11 start-page: 143 year: 2004 ident: 10.1016/j.mito.2017.08.007_bb0245 article-title: Functional characterization of mitochondria in neutrophils: a role restricted to apoptosis publication-title: Cell Death Differ. doi: 10.1038/sj.cdd.4401320 contributor: fullname: Maianski – volume: 101 start-page: 10726 year: 2004 ident: 10.1016/j.mito.2017.08.007_bb0080 article-title: Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0403649101 contributor: fullname: Coskun – volume: 570 start-page: 81 year: 2005 ident: 10.1016/j.mito.2017.08.007_bb0030 article-title: Detection of mtDNA with 4977bp deletion in blood cells and atherosclerotic lesions of patients with coronary artery disease publication-title: Mutat. Res. Mol. Mech. Mutagen. doi: 10.1016/j.mrfmmm.2004.10.003 contributor: fullname: Botto – volume: 20 start-page: 84 year: 2010 ident: 10.1016/j.mito.2017.08.007_bb0235 article-title: Mitochondrial DNA content in human omental adipose tissue publication-title: Obes. Surg. doi: 10.1007/s11695-009-9987-3 contributor: fullname: Lindinger – volume: 14 start-page: 1 year: 2015 ident: 10.1016/j.mito.2017.08.007_bb0415 article-title: Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging publication-title: Aging Cell doi: 10.1111/acel.12287 contributor: fullname: Ziegler – volume: 15 start-page: R31 year: 2014 ident: 10.1016/j.mito.2017.08.007_bb0165 article-title: Accounting for cellular heterogeneity is critical in epigenome-wide association studies publication-title: Genome Biol. doi: 10.1186/gb-2014-15-2-r31 contributor: fullname: Jaffe – volume: 61 start-page: 363 year: 2015 ident: 10.1016/j.mito.2017.08.007_bb0320 article-title: The association between leukocyte telomere length and mitochondrial DNA copy number in pregnant women: a pilot study publication-title: Clin. Lab. doi: 10.7754/Clin.Lab.2014.140313 contributor: fullname: Qiu – volume: 38 start-page: 216.e7 year: 2016 ident: 10.1016/j.mito.2017.08.007_bb0315 article-title: Reduced mitochondrial DNA copy number is a biomarker of Parkinson's disease publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2015.10.033 contributor: fullname: Pyle – volume: 24 start-page: 2201 year: 2015 ident: 10.1016/j.mito.2017.08.007_bb0340 article-title: Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddu739 contributor: fullname: Richmond – volume: 35 issue: 1445–56 year: 2013 ident: 10.1016/j.mito.2017.08.007_bb0325 article-title: Mitochondrial J haplogroup is associated with lower blood pressure and anti-oxidant status: findings in octo/nonagenarians from the BELFAST Study publication-title: Age (Dordr.) contributor: fullname: Rea – volume: 50 start-page: 2526 year: 2007 ident: 10.1016/j.mito.2017.08.007_bb0175 article-title: Strong association between mitochondrial DNA copy number and lipogenesis in human white adipose tissue publication-title: Diabetologia doi: 10.1007/s00125-007-0818-6 contributor: fullname: Kaaman – volume: 59 start-page: 785 year: 2005 ident: 10.1016/j.mito.2017.08.007_bb0220 article-title: Adverse socioeconomic position across the lifecourse increases coronary heart disease risk cumulatively: findings from the British women's heart and health study publication-title: J. Epidemiol. Community Health doi: 10.1136/jech.2004.029991 contributor: fullname: Lawlor – volume: 11 year: 2015 ident: 10.1016/j.mito.2017.08.007_bb0100 article-title: Assessing mitochondrial DNA variation and copy number in lymphocytes of ~2,000 sardinians using tailored sequencing analysis tools publication-title: PLoS Genet. contributor: fullname: Ding – volume: 183 start-page: 553 year: 1992 ident: 10.1016/j.mito.2017.08.007_bb0395 article-title: Counting target molecules by exponential polymerase chain reaction: copy number of mitochondrial DNA in rat tissues publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/0006-291X(92)90517-O contributor: fullname: Wiesner – volume: 18 start-page: 6927 year: 1990 ident: 10.1016/j.mito.2017.08.007_bb0075 article-title: Detection of a specific mitochondrial DNA deletion in tissues of older humans publication-title: Nucleic Acids Res. doi: 10.1093/nar/18.23.6927 contributor: fullname: Cortopassi – volume: 12 start-page: 913 year: 2007 ident: 10.1016/j.mito.2017.08.007_bb0375 article-title: Mitochondria, oxidative stress and cell death publication-title: Cell Death Differ. contributor: fullname: St John – volume: 35 start-page: 211 year: 2012 ident: 10.1016/j.mito.2017.08.007_bb0170 article-title: Mitochondrial ATP synthase: architecture, function and pathology publication-title: J. Inherit. Metab. Dis. doi: 10.1007/s10545-011-9382-9 contributor: fullname: Jonckheere – volume: 13 start-page: 86 year: 2012 ident: 10.1016/j.mito.2017.08.007_bb0130 article-title: DNA methylation arrays as surrogate measures of cell mixture distribution publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-13-86 contributor: fullname: Houseman – volume: 19 start-page: 582 year: 2012 ident: 10.1016/j.mito.2017.08.007_bb0190 article-title: The relationship between leukocyte mitochondrial DNA contents and metabolic syndrome in postmenopausal women publication-title: Menopause doi: 10.1097/gme.0b013e31823a3e46 contributor: fullname: Kim – volume: 99 start-page: 1571 year: 2016 ident: 10.1016/j.mito.2017.08.007_bb0210 article-title: Mitochondrial DNA copy number and biogenesis in different tissues of early- and late-lactating dairy cows publication-title: J. Dairy Sci. doi: 10.3168/jds.2015-9847 contributor: fullname: Laubenthal – volume: 74 start-page: 655 year: 2013 ident: 10.1016/j.mito.2017.08.007_bb0300 article-title: Low cerebrospinal fluid concentration of mitochondrial DNA in preclinical Alzheimer disease publication-title: Ann. Neurol. doi: 10.1002/ana.23955 contributor: fullname: Podlesniy – volume: 424 start-page: 245 year: 2013 ident: 10.1016/j.mito.2017.08.007_bb0400 article-title: Foam cells in atherosclerosis publication-title: Clin. Chim. Acta doi: 10.1016/j.cca.2013.06.006 contributor: fullname: Yu – volume: 95 year: 2016 ident: 10.1016/j.mito.2017.08.007_bb0145 article-title: Decreased Peripheral Mitochondrial DNA Copy Number is Associated with the Risk of Heart Failure and Long-term Outcomes publication-title: Med. (Baltimore) contributor: fullname: Huang – volume: 110 start-page: 1226 year: 2012 ident: 10.1016/j.mito.2017.08.007_bb0275 article-title: Telomeres and mitochondria in the aging heart publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.111.246868 contributor: fullname: Moslehi – ident: 10.1016/j.mito.2017.08.007_bb0260 – volume: 7 start-page: e43149 year: 2012 ident: 10.1016/j.mito.2017.08.007_bb0305 article-title: A case-control study of peripheral blood mitochondrial DNA copy number and risk of renal cell carcinoma publication-title: PLoS One doi: 10.1371/journal.pone.0043149 contributor: fullname: Purdue – volume: 19 start-page: 1109 year: 2012 ident: 10.1016/j.mito.2017.08.007_bb0185 article-title: Habitual physical exercise has beneficial effects on telomere length in postmenopausal women publication-title: Menopause doi: 10.1097/gme.0b013e3182503e97 contributor: fullname: Kim – volume: 631082 issue: 2013 year: 2013 ident: 10.1016/j.mito.2017.08.007_bb0285 article-title: Haplogroup T is an obesity risk factor: mitochondrial DNA haplotyping in a morbid obese population from southern Italy publication-title: Biomed. Res. Int. contributor: fullname: Nardelli – volume: 44 start-page: e80 year: 2007 ident: 10.1016/j.mito.2017.08.007_bb0060 article-title: Mitochondrial DNA haplogroups and type 2 diabetes: a study of 897 cases and 1010 controls publication-title: J. Med. Genet. doi: 10.1136/jmg.2007.048876 contributor: fullname: Chinnery – volume: 68 start-page: 551 year: 2014 ident: 10.1016/j.mito.2017.08.007_bb0035 article-title: Mitochondrial DNA variation and increased oxidative damage in euthymic patients with bipolar disorder publication-title: Psychiatry Clin. Neurosci. doi: 10.1111/pcn.12163 contributor: fullname: Chang – volume: 83 start-page: 94 year: 2009 ident: 10.1016/j.mito.2017.08.007_bb0390 article-title: Peripheral blood mitochondrial DNA content and dysregulation of glucose metabolism publication-title: Diabetes Res. Clin. Pr. doi: 10.1016/j.diabres.2008.10.002 contributor: fullname: Weng – volume: 25 start-page: 37 year: 2011 ident: 10.1016/j.mito.2017.08.007_bb0155 article-title: European mitochondrial DNA haplogroups and metabolic changes during antiretroviral therapy in AIDS Clinical Trials Group Study A5142* publication-title: AIDS doi: 10.1097/QAD.0b013e32833f9d02 contributor: fullname: Hulgan – volume: 18 start-page: 867 year: 2011 ident: 10.1016/j.mito.2017.08.007_bb0140 article-title: Depleted leukocyte mitochondrial DNA copy number in metabolic syndrome publication-title: J. Atheroscler. Thromb. doi: 10.5551/jat.8698 contributor: fullname: Huang – volume: 586017 issue: 2014 year: 2014 ident: 10.1016/j.mito.2017.08.007_bb0230 article-title: Mitochondrial DNA copy number in peripheral blood is independently associated with visceral fat accumulation in healthy young adults publication-title: Int. J. Endocrinol. contributor: fullname: Lee – volume: 13 start-page: 397 year: 2012 ident: 10.1016/j.mito.2017.08.007_bb0355 article-title: A. axis of ageing: telomeres, p53 and mitochondria publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm3352 contributor: fullname: Sahin – volume: 57 start-page: 134 year: 2003 ident: 10.1016/j.mito.2017.08.007_bb0215 article-title: Geographical variation in cardiovascular disease, risk factors, and their control in older women: British Women's Heart and Health Study publication-title: J. Epidemiol. Community Health doi: 10.1136/jech.57.2.134 contributor: fullname: Lawlor – year: 2000 ident: 10.1016/j.mito.2017.08.007_bb0295 contributor: fullname: Office for National Statistics, E. L – volume: 10 start-page: 186 year: 2013 ident: 10.1016/j.mito.2017.08.007_bb0105 article-title: Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and therapeutic options publication-title: Neurotherapeutics doi: 10.1007/s13311-013-0177-6 contributor: fullname: El-Hattab – volume: 1820 start-page: 553 year: 2012 ident: 10.1016/j.mito.2017.08.007_bb0085 article-title: A mitochondrial etiology of Alzheimer and Parkinson disease publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbagen.2011.08.008 contributor: fullname: Coskun – volume: 95 start-page: 1383 year: 1995 ident: 10.1016/j.mito.2017.08.007_bb0005 article-title: Increased expression of mitochondrial-encoded genes in skeletal muscle of humans with diabetes mellitus publication-title: J. Clin. Invest. doi: 10.1172/JCI117790 contributor: fullname: Antonetti – volume: 93 start-page: 177 year: 2015 ident: 10.1016/j.mito.2017.08.007_bb0015 article-title: Association of mitochondrial DNA levels with frailty and all-cause mortality publication-title: J. Mol. Med. doi: 10.1007/s00109-014-1233-3 contributor: fullname: Ashar – volume: 48 start-page: 32 year: 2014 ident: 10.1016/j.mito.2017.08.007_bb0090 article-title: Leukocyte mitochondrial DNA copy number in bipolar disorder publication-title: Prog. Neuro-Psychopharmacol. Biol. Psychiatry doi: 10.1016/j.pnpbp.2013.09.002 contributor: fullname: De Sousa – volume: 64 start-page: 10 year: 2016 ident: 10.1016/j.mito.2017.08.007_bb0025 article-title: Mitochondrial DNA copy number is reduced in male combat veterans with PTSD publication-title: Prog. Neuro-Psychopharmacol. Biol. Psychiatry doi: 10.1016/j.pnpbp.2015.06.012 contributor: fullname: Bersani – volume: 133 start-page: 1149 year: 2014 ident: 10.1016/j.mito.2017.08.007_bb0265 article-title: Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly publication-title: Hum. Genet. doi: 10.1007/s00439-014-1458-9 contributor: fullname: Mengel-From – year: 2015 ident: 10.1016/j.mito.2017.08.007_bb0330 article-title: Data resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES) publication-title: Int. J. Epidemiol. doi: 10.1093/ije/dyv072 contributor: fullname: Relton – volume: 27 start-page: 3008 year: 2016 ident: 10.1016/j.mito.2017.08.007_bb0410 article-title: Age-related decrease in mtDNA content as a consequence of mtDNA 4977bp deletion. Mitochondrial DNA. Part A. DNA mapping publication-title: Seq. Anal. contributor: fullname: Zabihi Diba – volume: 124 start-page: 530 year: 2014 ident: 10.1016/j.mito.2017.08.007_bb0125 article-title: Mitochondrial DNA copy number and future risk of B-cell lymphoma in a nested case-control study in the prospective EPIC cohort publication-title: Blood doi: 10.1182/blood-2013-10-532085 contributor: fullname: Hosnijeh – volume: 53 start-page: e218 year: 2011 ident: 10.1016/j.mito.2017.08.007_bb0180 article-title: Leukocyte mitochondrial DNA (mtDNA) content is associated with depression in old women publication-title: Arch. Gerontol. Geriatr. doi: 10.1016/j.archger.2010.11.019 contributor: fullname: Kim – volume: 86 start-page: e22 year: 2009 ident: 10.1016/j.mito.2017.08.007_bb0250 article-title: Increased peripheral blood mitochondrial DNA in type 2 diabetic patients with nephropathy publication-title: Diabetes Res. Clin. Pr. doi: 10.1016/j.diabres.2009.07.002 contributor: fullname: Malik – volume: 10 year: 2015 ident: 10.1016/j.mito.2017.08.007_bb0040 article-title: Mitochondria DNA change and oxidative damage in clinically stable patients with major depressive disorder publication-title: PLoS One contributor: fullname: Chang – volume: 183 start-page: 138 year: 2016 ident: 10.1016/j.mito.2017.08.007_bb0200 article-title: Correlates of peripheral blood mitochondrial DNA content in a general population publication-title: Am. J. Epidemiol. contributor: fullname: Knez – volume: 237 start-page: 220 year: 2014 ident: 10.1016/j.mito.2017.08.007_bb0045 article-title: Association between leukocyte mitochondrial DNA content and risk of coronary heart disease: a case-control study publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2014.08.051 contributor: fullname: Chen – volume: 55 start-page: 3309 year: 2006 ident: 10.1016/j.mito.2017.08.007_bb0020 article-title: Skeletal muscle mitochondrial functions, mitochondrial DNA copy numbers, and gene transcript profiles in type 2 diabetic and nondiabetic subjects at equal levels of low or high insulin and euglycemia publication-title: Diabetes doi: 10.2337/db05-1230 contributor: fullname: Asmann – volume: 102 start-page: 5618 year: 2005 ident: 10.1016/j.mito.2017.08.007_bb0370 article-title: Decline in skeletal muscle mitochondrial function with aging in humans publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0501559102 contributor: fullname: Short – volume: 327 start-page: 557 year: 2003 ident: 10.1016/j.mito.2017.08.007_bb0120 article-title: Measuring inconsistency in meta-analyses publication-title: BMJ doi: 10.1136/bmj.327.7414.557 contributor: fullname: Higgins – volume: 75 start-page: 456 year: 2011 ident: 10.1016/j.mito.2017.08.007_bb0405 article-title: Genetic variants associated with Von Willebrand factor levels in healthy men and women identified using the HumanCVD BeadChip publication-title: Ann. Hum. Genet. doi: 10.1111/j.1469-1809.2011.00654.x contributor: fullname: Zabaneh – volume: 37 start-page: 222 year: 2005 ident: 10.1016/j.mito.2017.08.007_bb0095 article-title: Mitochondrial DNA and disease publication-title: Ann. Med. doi: 10.1080/07853890510007368 contributor: fullname: Dimauro – volume: 78 start-page: 713 year: 2006 ident: 10.1016/j.mito.2017.08.007_bb0365 article-title: The power to detect disease associations with mitochondrial DNA haplogroups publication-title: Am. J. Hum. Genet. doi: 10.1086/502682 contributor: fullname: Samuels – volume: 48 start-page: 677 year: 2014 ident: 10.1016/j.mito.2017.08.007_bb0280 article-title: Evaluating the mitochondrial dna copy number in leukocytes and adipocytes from metabolic syndrome patients: pilot study publication-title: Mol. Biol. contributor: fullname: Mozhei – volume: 212 start-page: 167 year: 2006 ident: 10.1016/j.mito.2017.08.007_bb0350 article-title: Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2006.01.003 contributor: fullname: Rolo – volume: 8 year: 2013 ident: 10.1016/j.mito.2017.08.007_bb0195 article-title: The relationship between leukocyte mitochondrial DNA copy number and telomere length in community-dwelling elderly women publication-title: PLoS One contributor: fullname: Kim – volume: 92 start-page: 106 year: 2011 ident: 10.1016/j.mito.2017.08.007_bb0135 article-title: Tissue-specific differences in mitochondrial DNA content in type 2 diabetes publication-title: Diabetes Res. Clin. Pr. doi: 10.1016/j.diabres.2011.01.010 contributor: fullname: Hsieh – volume: 74 start-page: 765 year: 2004 ident: 10.1016/j.mito.2017.08.007_bb0290 article-title: A Simple Correction for Multiple Testing for Single-Nucleotide Polymorphisms in Linkage Disequilibrium with Each Other publication-title: Am. J. Hum. Genet. doi: 10.1086/383251 contributor: fullname: Nyholt |
| SSID | ssj0017122 |
| Score | 2.3097117 |
| Snippet | The mitochondrial genome is present at variable copy number between individuals. Mitochondria are vulnerable to oxidative stress, and their dysfunction may be... |
| SourceID | pubmedcentral proquest crossref pubmed |
| SourceType | Open Access Repository Aggregation Database Index Database |
| StartPage | 9 |
| SubjectTerms | Adult Aged Cardiovascular Diseases - epidemiology Cardiovascular Diseases - genetics DNA Copy Number Variations DNA, Mitochondrial - analysis Female Humans Metabolic Diseases - epidemiology Metabolic Diseases - genetics Middle Aged United Kingdom - epidemiology |
| Title | Cardiometabolic phenotypes and mitochondrial DNA copy number in two cohorts of UK women |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/28818596 https://search.proquest.com/docview/1930483779 https://pubmed.ncbi.nlm.nih.gov/PMC5832987 |
| Volume | 39 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db5swELfWVpP2Mq37arZ18qS9ISpwTQyPWUvXLV0mrYmWN4TBVlOpUDVBU_77nX18hPSlfegLQgaM8P04353PvyPkK9igkczAU2VcKxcs4tSNPBW4OoPZjXlKCrvL9fxSTObhaczjjlCha3tSSUMbyNrsnH2EtNtOoQHOQeZwBKnD8UFyP7EJpjdqBdI1BNYmh6s0gVYkY76BPxg0XpHbah2nk5GTlbdrBwuD2KTHf6VjqubeYZLHbIwkDZtG7K-uj24R_3u1TnGhyXAyO21M-VtlWB4tWsYL85JmJdk-s7qq63lhYAfUVBvF_VNXW7ms1GZowg-73Kwjheo0FKBvGRbpafQtkhfVCjPamHlRd97T6RheuD4yA2Ry8YTlXMVauX0C7cnv5Gx2cZFM4_l0h-wx0D2g-vZGP-L5z3ZpSfiM1bunMNFvu9--hXLP7djOnt0wR6avyMvaj6AjBMA-eaaK1-Q5VhZdvyF_t2BAOxhQgAHtwYACDKiBAUUY0EVBAQa0hgEtNZ2NqYXBWzI7i6cn525dQ8PNuMdWbipTlmtwG2UueJTLIApTLbgnwWwM_JT72gMPWHrHTKghmG5ZHgmmuAbHi3s5mKvvyG5RFuqAUC2lcZ5BnMMhl74Kj-E_F3kQwu2cMz0gTjNuyS1SpSRNDuF1Yr4rMaOcmLKnnhiQL83QwrWlWaZKC1VWywRcClvnQEQD8h6Huu2PhcbAjIYDInpCaG8wbOn9K8XiyrKmBzB3RaH48ID3fiQvOjh_Iruru0odkp1lXn2u0fQfVTKKfA |
| link.rule.ids | 230,315,782,786,887,27933,27934 |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cardiometabolic+phenotypes+and+mitochondrial+DNA+copy+number+in+two+cohorts+of+UK+women&rft.jtitle=Mitochondrion&rft.au=Guyatt%2C+Anna+L&rft.au=Burrows%2C+Kimberley&rft.au=Guthrie%2C+Philip+A+I&rft.au=Ring%2C+Sue&rft.date=2018-03-01&rft.eissn=1872-8278&rft.volume=39&rft.spage=9&rft.epage=19&rft_id=info:doi/10.1016%2Fj.mito.2017.08.007&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1567-7249&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1567-7249&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1567-7249&client=summon |