Modification of native fucoidan from Fucus evanescens by recombinant fucoidanase from marine bacteria Formosa algae

•Enzymatic cleavage of native fucoidan FeF by fucoidanase FFA1 yielded fractions HMP and LMP.•HMP are polymeric fragments of FeF that have a regular structure.•FeF and HMP have anticancer effect on colon cancer cells in vitro.•Anticancer effect of HMP was comparable to the activity of FeF but not id...

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Bibliographic Details
Published in:	Carbohydrate polymers Vol. 193; pp. 189 - 195
Main Authors:	Silchenko, Artem S., Rasin, Anton B., Kusaykin, Mikhail I., Malyarenko, Olesya S., Shevchenko, Natalie M., Zueva, Anastasya O., Kalinovsky, Anatoly I., Zvyagintseva, Tatyana N., Ermakova, Svetlana P.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-08-2018
Subjects:	Anticancer activity Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Biocatalysis Carbohydrate Conformation Cell Proliferation - drug effects Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Endo-fucoidanase Fucoidan depolymerization Fucoidan from Fucus evanescens Fucoidanase Fucus - chemistry Fucus - enzymology Fucus - metabolism Humans Hydrolases - chemistry Hydrolases - metabolism Marine bacteria Polysaccharides - chemistry Polysaccharides - metabolism Polysaccharides - pharmacology Recombinant Proteins - chemistry Recombinant Proteins - metabolism Structure-Activity Relationship Tumor Cells, Cultured Fucoidanase Fucoidan from Fucus evanescens Fucoidan depolymerization Endo-fucoidanase Anticancer activity Marine bacteria
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