Developing Streptomyces venezuelae as a cell factory for the production of small molecules used in drug discovery

The heterologous expression of biosynthetic pathways is an indispensable tool for drug discovery and development from natural products. Streptomyces venezuelae is a promising heterologous host as it offers several attractive advantages, such as rapid growth rate, convenient genetic manipulation, and...

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Published in:	Archives of pharmacal research Vol. 38; no. 9; pp. 1606 - 1616
Main Authors:	Kim, Eun Ji, Yang, Inho, Yoon, Yeo Joon
Format:	Journal Article
Language:	English
Published:	Seoul Pharmaceutical Society of Korea 01-09-2015 대한약학회
Subjects:	Animals biochemical pathways derivatization Drug Discovery - methods drugs genetic engineering Genetic Engineering - methods genetically modified organisms heterologous gene expression host strains Humans Medicine multigene family mutants Pharmacology/Toxicology Pharmacy products Review Streptomyces Streptomyces - genetics Streptomyces - metabolism Streptomyces venezuelae 약학 Secondary metabolism . Pathway engineering Heterologous expression S. venezuelae
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Abstract	The heterologous expression of biosynthetic pathways is an indispensable tool for drug discovery and development from natural products. Streptomyces venezuelae is a promising heterologous host as it offers several attractive advantages, such as rapid growth rate, convenient genetic manipulation, and an abundant supply of common biosynthetic building blocks. In recent decades, several S. venezuelae mutant strains have been constructed and used to facilitate the synthesis and derivatization of diverse natural products. In this review article, we have provided a schematic look at these host strains, which were used to synthesize natural products from genetically engineered biosynthetic gene clusters.
AbstractList	The heterologous expression of biosynthetic pathways is an indispensable tool for drug discovery and development from natural products. Streptomyces venezuelae is a promising heterologous host as it offers several attractive advantages, such as rapid growth rate, convenient genetic manipulation, and an abundant supply of common biosynthetic building blocks. In recent decades, several S. venezuelae mutant strains have been constructed and used to facilitate the synthesis and derivatization of diverse natural products. In this review article, we have provided a schematic look at these host strains, which were used to synthesize natural products from genetically engineered biosynthetic gene clusters. The heterologous expression of biosynthetic pathways is an indispensable tool for drug discovery and development from natural products. Streptomyces venezuelae is a promising heterologous host as it offers several attractive advantages, such as rapid growth rate, convenient genetic manipulation, and an abundant supply of common biosynthetic building blocks. In recent decades, several S . venezuelae mutant strains have been constructed and used to facilitate the synthesis and derivatization of diverse natural products. In this review article, we have provided a schematic look at these host strains, which were used to synthesize natural products from genetically engineered biosynthetic gene clusters. The heterologous expression of biosyntheticpathways is an indispensable tool for drug discovery anddevelopment from natural products. Streptomycesvenezuelae is a promising heterologous host as it offersseveral attractive advantages, such as rapid growth rate,convenient genetic manipulation, and an abundant supplyof common biosynthetic building blocks. In recent decades,several S. venezuelae mutant strains have been constructedand used to facilitate the synthesis and derivatization ofdiverse natural products. In this review article, we haveprovided a schematic look at these host strains, which wereused to synthesize natural products from genetically engineeredbiosynthetic gene clusters. KCI Citation Count: 25
Author	Yang, Inho Kim, Eun Ji Yoon, Yeo Joon
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Cites_doi	10.1007/s00253-011-3592-9 10.1021/np200906s 10.1016/S1367-5931(03)00020-6 10.1021/np050523q 10.1128/AEM.02296-07 10.1006/mben.2000.0167 10.1007/s00253-008-1674-0 10.1128/AAC.46.9.2772-2778.2002 10.1016/j.abb.2004.06.009 10.1021/jo00303a029 10.1039/b109542k 10.1038/417141a 10.1007/s00253-007-1101-y 10.1016/S1074-5521(00)00075-2 10.1021/ja072909o 10.1124/pr.56.2.6 10.1039/C0NP00037J 10.1002/anie.200806121 10.1093/gbe/evq013 10.1016/S0378-1119(02)00860-0 10.1002/anie.200503195 10.1128/JB.05583-11 10.1039/c1np00045d 10.1007/s00253-013-5503-8 10.1016/S1074-5521(98)90293-9 10.1007/s00253-007-1096-4 10.1038/nbt820 10.1021/ja992810k 10.1007/s00253-006-0318-5 10.1002/jms.1240 10.1126/science.287.5453.640 10.1016/j.jbiotec.2013.05.014 10.1021/np060026p 10.1128/JB.00596-10 10.1039/c3np70034h 10.1186/1471-2164-12-175 10.1038/35000624 10.1016/j.chembiol.2011.12.014 10.1099/13500872-145-4-855 10.1039/c3np70060g 10.4014/jmb.1108.08012 10.4014/jmb.1005.05038 10.1021/sb300080t 10.1016/j.chembiol.2005.02.016 10.1016/S0031-9422(00)00235-1 10.1073/pnas.0803164105 10.1073/pnas.95.21.12111 10.1021/jm00340a034 10.1016/S0163-7258(97)00096-X 10.1016/j.tim.2007.03.004 10.1021/np960085a 10.1021/cr0301088 10.1128/AEM.02527-10 10.1007/s00253-010-2890-y 10.7164/antibiotics.30.1012 10.1007/s00253-009-2326-8 10.1094/MPMI-23-2-0161 10.1016/j.carres.2006.03.012 10.7164/antibiotics.49.560 10.1002/cbic.200700610 10.1128/JB.00204-08 10.1039/np9971400099 10.1074/jbc.M309135200 10.1016/j.jbiotec.2009.03.013 10.1105/tpc.7.7.1085 10.1021/bi052075r 10.1007/978-1-4899-2909-9 10.1038/nchembio.671 10.1021/ol302575h 10.1073/pnas.211433198 10.2174/0929867305666220319104359
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References	Park, Park, Nepal, Han, Ban, Yoo, Kim, Kim, Kim, Sohng, Yoon (CR58) 2011; 7 Osswald, Zipf, Schmidt, Maier, Bernauer, Müller, Wenzel (CR51) 2014; 3 Park, Jung, Park, Park, Yoon (CR52) 2007; 42 Julien, Shah (CR28) 2002; 46 Minotti, Menna, Salvatorelli, Cairo, Gianni (CR40) 2004; 56 Springob, Nakajima, Yamazaki, Saito (CR64) 2003; 20 Olano, Abdelfattah, Gullón, Braña, Rohr, Méndez, Salas (CR47) 2008; 9 Leimkuhler, Fridman, Lupoli, Walker, Walsh, Kahne (CR36) 2007; 129 Medema, Trefzer, Kovalchuk, van den Berg, Müller, Heijne, Wu, Alam, Ronning, Nierman, Bovenberg, Breitling, Takano (CR39) 2010; 2 Omura, Ikeda, Ishikawa, Hanamoto, Takahashi, Shinose, Takahashi, Horikawa, Nakazawa, Osonoe, Kikuchi, Shiba, Sakaki, Hattori (CR48) 2001; 98 Chang, Flatt, Gerwick, Nguyen, Willis, Sherman (CR9) 2002; 296 Gerth, Bedorf, Höfle, Irschik, Reichenbach (CR15) 1996; 49 Xue, Sherman (CR73) 2000; 403 Han, Shinde, Park, Cho, Lee, Ban, Yoo, Kim, Kim, Park, Kim, Lee, Yoon (CR20) 2012; 93 Hertweck (CR23) 2009; 48 Magnet, Blanchard (CR38) 2005; 105 Zhao, Ahlert, Xue, Thorson, Sherman, Liu (CR78) 1999; 121 Han, Park, Lee, Ban, Yoo, Kim, Kim, Kim, Sohng, Yoon (CR18) 2011; 77 Park, Yoon, Paik, Park, Jung, Ban, Kim, Yoo, Han, Yoon (CR55) 2009; 141 Han, Park, Park, Lee, Kim, Kim, Yoon (CR19) 2011; 21 Weinstein, Luedemann, Oden, Wagman, Rosselet, Marquez, Coniglio, Charney, Herzog, Black (CR70) 1963; 6 Gerwick, Moore (CR16) 2012; 19 Arcamone, Cassinelli (CR1) 1998; 5 Gantt, Peltier-Pain, Thorson (CR14) 2011; 28 Lee, Park, Kim, Jung, Park, Choi, Kim, Kim, Ahn, Sherman, Yoon (CR35) 2006; 69 Tang, Shah, Chung, Carney, Katz, Khosla, Julien (CR66) 2000; 287 Bollag, McQueney, Zhu, Hensens, Koupal, Liesch, Goetz, Lazarides, Woods (CR6) 1995; 55 Newman, Cragg (CR44) 2012; 75 Salas, Méndez (CR61) 2007; 15 Lu, Leimkuhler, Gatto, Kruger, Oberthür, Kahne, Walsh (CR37) 2005; 12 Xue, Sherman (CR74) 2001; 3 Ikeda, Ishikawa, Hanamoto, Shinose, Kikuchi, Shiba, Sakaki, Hattori, Omura (CR27) 2003; 21 Park, Ahn, Han, Park, Yoon (CR59) 2011; 21 Harborne, Willams (CR21) 2000; 55 Orjala, Gerwick (CR50) 1996; 59 Wang, Yan, Zhang, An, Wang, Tian, Jiang, Chen, Huang, Yin, Zhang, Gao, Liu, Zhu, Xiang (CR69) 2010; 192 Harborne, Mabry, Mabry (CR22) 1975 Hopwood (CR26) 2012; 517 Borisova, Zhang, Takahashi, Zhang, Wong, Thorson, Liu (CR7) 2006; 45 Mutka, Carney, Liu, Kennedy (CR42) 2006; 45 Jung, Jeong, Park, Choi, Park, Park, Yoon (CR31) 2008; 74 Park, Paik, Ahn, Park, Yoon (CR57) 2010; 20 Flatt, O’Connell, McPhail, Zeller, Willis, Sherman, Gerwick (CR12) 2006; 69 Shinde, Han, Cho, Lee, Ban, Yoo, Kim, Kim, Song, Park, Lee, Yoon (CR63) 2013; 168 Barbe, Bouzon, Mangenot, Badet, Poulain, Segurens, Vallenet, Marlière, Weissenbach (CR3) 2011; 193 Arcamone, Animati, Capranico, Lombardi, Pratesi, Manzini, Supino, Zunino (CR2) 1997; 76 Shen (CR62) 2003; 7 Zhang, Boghigian, Armando, Pfeifer (CR77) 2011; 28 Bryskier (CR8) 2015 Corcoran, Huber, Huber (CR10) 1977; 30 Thapa, Oh, Lee, Liou, Park, Yoon, Sohng (CR67) 2007; 76 Jung, Kim, Yoo, Ban, Kim, Yoon (CR32) 2014; 98 Park, Han, Ban, Yoo, Kim, Yoon (CR56) 2010; 85 Nagabhushan, Miller, Weinstein, Whelton, Neu (CR43) 1982 Dixon, Paiva (CR11) 1995; 7 Hong, Park, Choi, Sohng, Yoon (CR24) 2004; 238 Park, Park, Jung, Han, Ban, Kim, Sohng, Sim, Yoon (CR54) 2008; 81 Jung, Han, Hong, Park, Choi, Park, Yoon (CR30) 2007; 76 Kim, Lee, Choi, Pereira, Ban, Yoo, Kim, Park, Sherman, Gerwick, Yoon (CR34) 2012; 14 Gunasekera, Gunasekera, Longley, Schulte (CR17) 1990; 55 Molnár, Schupp, Ono, Zirkle, Milnamow, Nowak-Thompson, Engel, Toupet, Stratmann, Cyr, Gorlach, Mayo, Hu, Goff, Schmid, Ligon (CR41) 2000; 7 Bentley, Chater, Cerdeño-Tárraga, Challis, Thomson, James, Harris, Quail, Kieser, Harper, Bateman, Brown, Chandra, Chen, Collins, Cronin, Fraser, Goble, Hidalgo, Hornsby, Howarth, Huang, Kieser, Larke, Murphy, Oliver, O’Neil, Rabbinowitsch, Rajandream, Rutherford, Rutter, Seeger, Saunders, Sharp, Squares, Squares, Taylor, Warren, Wietzorrek, Woodward, Barrell, Parkhill, Hopwood (CR4) 2002; 417 Kharel, Subba, Basnet, Woo, Lee, Liou, Sohng (CR33) 2004; 429 Toshima (CR68) 2006; 341 Xue, Zhao, Liu, Sherman (CR76) 1998; 95 Wolucka, Van Montagu (CR72) 2003; 278 Bignell, Seipke, Huguet-Tapia, Chambers, Parry, Loria (CR5) 2010; 23 Park, Hong, Parajuli, Jung, Park, Lim, Sohng, Yoon (CR53) 2008; 105 Pullan, Chandra, Bibb, Merrick (CR60) 2011; 12 Jung, Lee, Hong, Park, Jeong, Han, Sohng, Kim, Choi, Sherman, Yoon (CR29) 2006; 72 Ohnishi, Ishikawa, Hara, Suzuki, Ikenoya, Ikeda, Yamashita, Hattori, Horinouchi (CR46) 2008; 190 Ongley, Bian, Neilan, Müller (CR49) 2013; 30 Xue, Wilson, Zhao, Hw, Sherman (CR75) 1998; 5 Fouces, Mellado, Díez, Barredo (CR13) 1999; 145 Stevens, Hari, Boddy (CR65) 2013; 30 Hopwood (CR25) 2007 Weymouth-Wilson (CR71) 1997; 14 Y Xue (638_CR76) 1998; 95 DR Bignell (638_CR5) 2010; 23 B Julien (638_CR28) 2002; 46 C Olano (638_CR47) 2008; 9 SE Ongley (638_CR49) 2013; 30 W Lu (638_CR37) 2005; 12 SR Park (638_CR55) 2009; 141 AR Han (638_CR18) 2011; 77 WS Jung (638_CR29) 2006; 72 LP Thapa (638_CR67) 2007; 76 MK Kharel (638_CR33) 2004; 429 I Molnár (638_CR41) 2000; 7 JW Park (638_CR52) 2007; 42 Y Xue (638_CR73) 2000; 403 SC Mutka (638_CR42) 2006; 45 H Ikeda (638_CR27) 2003; 21 SA Borisova (638_CR7) 2006; 45 Y Ohnishi (638_CR46) 2008; 190 G Minotti (638_CR40) 2004; 56 SR Park (638_CR57) 2010; 20 V Barbe (638_CR3) 2011; 193 TL Nagabhushan (638_CR43) 1982 JW Park (638_CR58) 2011; 7 SP Gunasekera (638_CR17) 1990; 55 C Hertweck (638_CR23) 2009; 48 JA Salas (638_CR61) 2007; 15 PB Shinde (638_CR63) 2013; 168 SD Bentley (638_CR4) 2002; 417 K Toshima (638_CR68) 2006; 341 JW Corcoran (638_CR10) 1977; 30 JS Hong (638_CR24) 2004; 238 JW Park (638_CR53) 2008; 105 SR Park (638_CR59) 2011; 21 DJ Newman (638_CR44) 2012; 75 DM Bollag (638_CR6) 1995; 55 MH Medema (638_CR39) 2010; 2 B Shen (638_CR62) 2003; 7 RA Dixon (638_CR11) 1995; 7 ST Pullan (638_CR60) 2011; 12 MJ Weinstein (638_CR70) 1963; 6 C Osswald (638_CR51) 2014; 3 SR Park (638_CR56) 2010; 85 DC Stevens (638_CR65) 2013; 30 Y Xue (638_CR74) 2001; 3 C Leimkuhler (638_CR36) 2007; 129 AR Han (638_CR19) 2011; 21 SR Park (638_CR54) 2008; 81 A Bryskier (638_CR8) 2015 RW Gantt (638_CR14) 2011; 28 DA Hopwood (638_CR25) 2007 JB Harborne (638_CR21) 2000; 55 WS Jung (638_CR31) 2008; 74 L Tang (638_CR66) 2000; 287 F Arcamone (638_CR2) 1997; 76 K Gerth (638_CR15) 1996; 49 S Magnet (638_CR38) 2005; 105 F Arcamone (638_CR1) 1998; 5 EJ Kim (638_CR34) 2012; 14 JB Harborne (638_CR22) 1975 WS Jung (638_CR30) 2007; 76 SK Lee (638_CR35) 2006; 69 WS Jung (638_CR32) 2014; 98 PM Flatt (638_CR12) 2006; 69 R Fouces (638_CR13) 1999; 145 L Zhao (638_CR78) 1999; 121 Z Chang (638_CR9) 2002; 296 J Orjala (638_CR50) 1996; 59 Y Xue (638_CR75) 1998; 5 AR Han (638_CR20) 2012; 93 DA Hopwood (638_CR26) 2012; 517 H Zhang (638_CR77) 2011; 28 S Omura (638_CR48) 2001; 98 XJ Wang (638_CR69) 2010; 192 WH Gerwick (638_CR16) 2012; 19 BA Wolucka (638_CR72) 2003; 278 AC Weymouth-Wilson (638_CR71) 1997; 14 K Springob (638_CR64) 2003; 20
References_xml	– volume: 93 start-page: 1147 year: 2012 end-page: 1156 ident: CR20 article-title: Engineered biosynthesis of glycosylated derivatives of narbomycin and evaluation of their antibacterial activities publication-title: Applied Microbiology and Biotechnology doi: 10.1007/s00253-011-3592-9 contributor: fullname: Yoon – volume: 75 start-page: 311 year: 2012 end-page: 353 ident: CR44 article-title: Natural products as sources of new drugs over the 30 years from 1981 to 2010 publication-title: Journal of Natural Products doi: 10.1021/np200906s contributor: fullname: Cragg – volume: 7 start-page: 285 year: 2003 end-page: 295 ident: CR62 article-title: Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigms publication-title: Current Opinion in Chemical Biology doi: 10.1016/S1367-5931(03)00020-6 contributor: fullname: Shen – volume: 69 start-page: 938 year: 2006 end-page: 944 ident: CR12 article-title: Characterization of the initial enzymatic steps of barbamide biosynthesis publication-title: Journal of Natural Products doi: 10.1021/np050523q contributor: fullname: Gerwick – volume: 238 start-page: 391 year: 2004 end-page: 399 ident: CR24 article-title: New olivosyl derivatives of methymycin/pikromycin from an engineered strain of publication-title: FEMS Microbiology Letters contributor: fullname: Yoon – volume: 74 start-page: 1972 year: 2008 end-page: 1979 ident: CR31 article-title: Enhanced heterologous production of desosaminyl macrolides and their hydroxylated derivatives by overexpression of the regulatory gene in publication-title: Applied and Environmental Microbiology doi: 10.1128/AEM.02296-07 contributor: fullname: Yoon – volume: 3 start-page: 15 year: 2001 end-page: 26 ident: CR74 article-title: Biosynthesis and combinatorial biosynthesis of pikromycin-related macrolides in publication-title: Metabolic Engineering doi: 10.1006/mben.2000.0167 contributor: fullname: Sherman – volume: 81 start-page: 109 year: 2008 end-page: 117 ident: CR54 article-title: Heterologous production of epothilones B and D in publication-title: Applied Microbiology and Biotechnology doi: 10.1007/s00253-008-1674-0 contributor: fullname: Yoon – volume: 46 start-page: 2772 year: 2002 end-page: 2778 ident: CR28 article-title: Heterologous expression of epothilone biosynthetic genes in publication-title: Antimicrobial Agents and Chemotherapy doi: 10.1128/AAC.46.9.2772-2778.2002 contributor: fullname: Shah – volume: 429 start-page: 204 year: 2004 end-page: 214 ident: CR33 article-title: A gene cluster for biosynthesis of kanamycin from : Comparison with gentamicin biosynthetic gene cluster publication-title: Archives of Biochemistry and Biophysics doi: 10.1016/j.abb.2004.06.009 contributor: fullname: Sohng – volume: 55 start-page: 4912 year: 1990 end-page: 4915 ident: CR17 article-title: Discodermolide: A new bioactive polyhydroxylated lactone from the marine sponge publication-title: The Journal of Organic Chemistry doi: 10.1021/jo00303a029 contributor: fullname: Schulte – volume: 20 start-page: 288 year: 2003 end-page: 303 ident: CR64 article-title: Recent advances in the biosynthesis and accumulation of anthocyanins publication-title: Natural Product Reports doi: 10.1039/b109542k contributor: fullname: Saito – volume: 417 start-page: 141 year: 2002 end-page: 147 ident: CR4 article-title: Complete genome sequence of the model actinomycete A3(2) publication-title: Nature doi: 10.1038/417141a contributor: fullname: Hopwood – volume: 76 start-page: 1373 year: 2007 end-page: 1381 ident: CR30 article-title: Bioconversion of 12-, 14-, and 16-membered ring aglycones to glycosylated macrolides in an engineered strain of publication-title: Applied Microbiology and Biotechnology doi: 10.1007/s00253-007-1101-y contributor: fullname: Yoon – volume: 7 start-page: 97 year: 2000 end-page: 109 ident: CR41 article-title: The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from So ce90 publication-title: Chemistry and Biology doi: 10.1016/S1074-5521(00)00075-2 contributor: fullname: Ligon – volume: 129 start-page: 10546 year: 2007 end-page: 10550 ident: CR36 article-title: Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A publication-title: Journal of the American Chemical Society doi: 10.1021/ja072909o contributor: fullname: Kahne – volume: 56 start-page: 185 year: 2004 end-page: 229 ident: CR40 article-title: Anthracyclines: Molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity publication-title: Pharmacological Reviews doi: 10.1124/pr.56.2.6 contributor: fullname: Gianni – volume: 28 start-page: 125 year: 2011 end-page: 151 ident: CR77 article-title: Methods and options for the heterologous production of complex natural production publication-title: Natural Product Reports doi: 10.1039/C0NP00037J contributor: fullname: Pfeifer – volume: 48 start-page: 4688 year: 2009 end-page: 4716 ident: CR23 article-title: The biosynthetic logic of polyketide diversity publication-title: Angewandte Chemie International Edition doi: 10.1002/anie.200806121 contributor: fullname: Hertweck – year: 2007 ident: CR25 publication-title: in nature and medicine: The antibiotic markers contributor: fullname: Hopwood – volume: 2 start-page: 212 year: 2010 end-page: 224 ident: CR39 article-title: The sequence of a 1.8-Mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways publication-title: Genome Biology and Evolution doi: 10.1093/gbe/evq013 contributor: fullname: Takano – volume: 296 start-page: 235 year: 2002 end-page: 247 ident: CR9 article-title: The barbamide biosynthetic gene cluster: A novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit publication-title: Gene doi: 10.1016/S0378-1119(02)00860-0 contributor: fullname: Sherman – volume: 45 start-page: 2748 year: 2006 end-page: 2753 ident: CR7 article-title: Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII: Opportunities, limitations, and mechanistic hypotheses publication-title: Angewandte Chemie International Edition doi: 10.1002/anie.200503195 contributor: fullname: Liu – volume: 193 start-page: 5055 year: 2011 end-page: 5056 ident: CR3 article-title: Complete genome sequence of NRRL 8057, a producer of antibiotics and fluorometabolites publication-title: Journal of Bacteriology doi: 10.1128/JB.05583-11 contributor: fullname: Weissenbach – volume: 28 start-page: 1811 year: 2011 end-page: 1853 ident: CR14 article-title: Enzymatic methods for glyco (diversification/randomization) of drugs and small molecules publication-title: Natural Product Reports doi: 10.1039/c1np00045d contributor: fullname: Thorson – volume: 98 start-page: 3701 year: 2014 end-page: 3713 ident: CR32 article-title: Characterization and engineering of the ethylmalonyl-CoA pathway towards the improved heterologous production of polyketides in publication-title: Applied Microbiology and Biotechnology doi: 10.1007/s00253-013-5503-8 contributor: fullname: Yoon – volume: 5 start-page: 661 year: 1998 end-page: 667 ident: CR75 article-title: Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in publication-title: Chemistry and Biology doi: 10.1016/S1074-5521(98)90293-9 contributor: fullname: Sherman – volume: 55 start-page: 2325 year: 1995 end-page: 2333 ident: CR6 article-title: Epothilones, a new class of microtubule-stabilizing agents with a Taxol-like mechanism of action publication-title: Cancer Research contributor: fullname: Woods – volume: 76 start-page: 1357 year: 2007 end-page: 1364 ident: CR67 article-title: Heterologous expression of the kanamycin biosynthetic gene cluster (pSKC2) in YJ003 publication-title: Applied Microbiology and Biotechnology doi: 10.1007/s00253-007-1096-4 contributor: fullname: Sohng – volume: 21 start-page: 526 year: 2003 end-page: 531 ident: CR27 article-title: Complete genome sequence and comparative analysis of the industrial microorganism publication-title: Nature Biotechnology doi: 10.1038/nbt820 contributor: fullname: Omura – volume: 121 start-page: 9881 year: 1999 end-page: 9882 ident: CR78 article-title: Engineering a methymycin/pikromycin–calicheamicin hybrid: Construction of two new macrolides carrying a designed sugar moiety publication-title: Journal of the American Chemical Society doi: 10.1021/ja992810k contributor: fullname: Liu – volume: 517 start-page: 2 year: 2012 end-page: 449 ident: CR26 article-title: Natural product biosynthesis by microorganisms and plants, part C publication-title: Methods in Enzymology contributor: fullname: Hopwood – volume: 72 start-page: 763 year: 2006 end-page: 769 ident: CR29 article-title: Heterologous expression of tylosin polyketide synthase and production of a hybrid bioactive macrolide in publication-title: Applied Microbiology and Biotechnology doi: 10.1007/s00253-006-0318-5 contributor: fullname: Yoon – year: 1982 ident: CR43 article-title: Structure–activity relationships in aminoglycoside–aminocyclitol antibiotics publication-title: The aminoglycosides: Microbiology, clinical use and toxicology contributor: fullname: Neu – volume: 42 start-page: 1136 year: 2007 end-page: 1147 ident: CR52 article-title: Analysis of intracellular short organic acid-coenzyme A esters from actinomycetes using liquid chromatography–electrospray ionization–mass spectrometry publication-title: Journal of Mass Spectrometry doi: 10.1002/jms.1240 contributor: fullname: Yoon – volume: 287 start-page: 640 year: 2000 end-page: 642 ident: CR66 article-title: Cloning and heterologous expression of the epothilone gene cluster publication-title: Science doi: 10.1126/science.287.5453.640 contributor: fullname: Julien – volume: 168 start-page: 142 year: 2013 end-page: 148 ident: CR63 article-title: Combinatorial biosynthesis and antibacterial evaluation of glycosylated derivatives of 12-membered macrolide antibiotic YC-17 publication-title: Journal of Biotechnology doi: 10.1016/j.jbiotec.2013.05.014 contributor: fullname: Yoon – volume: 69 start-page: 847 year: 2006 end-page: 849 ident: CR35 article-title: Neopikromycin and novapikromycin from the pikromycin biosynthetic pathway of publication-title: Journal of Natural Products doi: 10.1021/np060026p contributor: fullname: Yoon – volume: 192 start-page: 4526 year: 2010 end-page: 4527 ident: CR69 article-title: Genome sequence of the milbemycin-producing bacterium publication-title: Journal of Bacteriology doi: 10.1128/JB.00596-10 contributor: fullname: Xiang – volume: 30 start-page: 1121 year: 2013 end-page: 1138 ident: CR49 article-title: Recent advances in the heterologous expression of microbial natural product biosynthetic pathways publication-title: Natural Product Reports doi: 10.1039/c3np70034h contributor: fullname: Müller – volume: 12 start-page: 175 year: 2011 end-page: 188 ident: CR60 article-title: Genome-wide analysis of the role of GlnR in provides new insights into global nitrogen regulation in actinomycetes publication-title: BMC Genomics doi: 10.1186/1471-2164-12-175 contributor: fullname: Merrick – volume: 403 start-page: 571 year: 2000 end-page: 575 ident: CR73 article-title: Alternative modular polyketide synthase expression controls macrolactone structure publication-title: Nature doi: 10.1038/35000624 contributor: fullname: Sherman – volume: 19 start-page: 85 year: 2012 end-page: 98 ident: CR16 article-title: Lessons from the past and charting the future of marine natural products drug discovery and chemical biology publication-title: Chemistry and Biology doi: 10.1016/j.chembiol.2011.12.014 contributor: fullname: Moore – volume: 145 start-page: 855 year: 1999 end-page: 868 ident: CR13 article-title: The tylosin biosynthetic cluster from : Genetic organization of the left region publication-title: Microbiology doi: 10.1099/13500872-145-4-855 contributor: fullname: Barredo – volume: 30 start-page: 1391 year: 2013 end-page: 1411 ident: CR65 article-title: The role of transcription in heterologous expression of polyketides in bacterial hosts publication-title: Natural Product Reports doi: 10.1039/c3np70060g contributor: fullname: Boddy – volume: 21 start-page: 1143 year: 2011 end-page: 1146 ident: CR59 article-title: Enhanced flavonoid production in via metabolic engineering publication-title: Journal of Microbiology and Biotechnology doi: 10.4014/jmb.1108.08012 contributor: fullname: Yoon – volume: 20 start-page: 1295 year: 2010 end-page: 1299 ident: CR57 article-title: Biosynthesis of plant-specific flavones and flavonols in publication-title: Journal of Microbiology and Biotechnology doi: 10.4014/jmb.1005.05038 contributor: fullname: Yoon – volume: 3 start-page: 759 year: 2014 end-page: 772 ident: CR51 article-title: Modular construction of a functional artificial epothilone polyketide pathway publication-title: ACS Synthetic Biology doi: 10.1021/sb300080t contributor: fullname: Wenzel – volume: 12 start-page: 527 year: 2005 end-page: 534 ident: CR37 article-title: AknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A publication-title: Chemistry and Biology doi: 10.1016/j.chembiol.2005.02.016 contributor: fullname: Walsh – volume: 55 start-page: 481 year: 2000 end-page: 504 ident: CR21 article-title: Advances in flavonoid research since 1992 publication-title: Phyotochemistry doi: 10.1016/S0031-9422(00)00235-1 contributor: fullname: Willams – volume: 105 start-page: 8399 year: 2008 end-page: 8404 ident: CR53 article-title: Genetic dissection of the biosynthetic route to gentamicin A2 by heterologous expression of its minimal gene set publication-title: Proceedings of the National Academy of Sciences USA doi: 10.1073/pnas.0803164105 contributor: fullname: Yoon – volume: 95 start-page: 12111 year: 1998 end-page: 12116 ident: CR76 article-title: A gene cluster for macrolide antibiotic biosynthesis in : Architecture of metabolic diversity publication-title: Proceedings of the National Academy of Sciences USA doi: 10.1073/pnas.95.21.12111 contributor: fullname: Sherman – volume: 6 start-page: 463 year: 1963 end-page: 464 ident: CR70 article-title: Gentamicin: A new antibiotic complex from publication-title: Journal of Medicinal Chemistry doi: 10.1021/jm00340a034 contributor: fullname: Black – volume: 76 start-page: 18 year: 1997 end-page: 124 ident: CR2 article-title: New developments in antitumor anthracyclines publication-title: Pharmacology and Therapeutics doi: 10.1016/S0163-7258(97)00096-X contributor: fullname: Zunino – volume: 15 start-page: 219 year: 2007 end-page: 232 ident: CR61 article-title: Engineering the glycosylation of natural products in actinomycetes publication-title: Trends in Microbiology doi: 10.1016/j.tim.2007.03.004 contributor: fullname: Méndez – volume: 59 start-page: 427 year: 1996 end-page: 430 ident: CR50 article-title: Barbamide, a chlorinated metabolite with molluscicidal activity from the Caribbean cyanobacterium publication-title: Journal of Natural Products doi: 10.1021/np960085a contributor: fullname: Gerwick – volume: 105 start-page: 477 year: 2005 end-page: 498 ident: CR38 article-title: Molecular insights into aminoglycoside action and resistance publication-title: Chemical Reviews doi: 10.1021/cr0301088 contributor: fullname: Blanchard – volume: 77 start-page: 4912 year: 2011 end-page: 4923 ident: CR18 article-title: Development of a -based combinatorial biosynthetic system for the production of glycosylated derivatives of doxorubicin and its biosynthetic intermediates publication-title: Applied and Environmental Microbiology doi: 10.1128/AEM.02527-10 contributor: fullname: Yoon – volume: 21 start-page: 613 year: 2011 end-page: 616 ident: CR19 article-title: Biosynthesis of glycosylated derivatives of tylosin in publication-title: Journal of Microbiology and Biotechnology doi: 10.1007/s00253-010-2890-y contributor: fullname: Yoon – volume: 5 start-page: 391 year: 1998 end-page: 419 ident: CR1 article-title: Biosynthetic anthracyclines publication-title: Current Medicinal Chemistry contributor: fullname: Cassinelli – volume: 30 start-page: 1012 year: 1977 end-page: 1014 ident: CR10 article-title: Relationship of ribosomal binding and antibacterial properties of tylosin-type antibiotics publication-title: The Journal of Antibiotics doi: 10.7164/antibiotics.30.1012 contributor: fullname: Huber – volume: 85 start-page: 1227 year: 2010 end-page: 1239 ident: CR56 article-title: Genetic engineering of macrolide biosynthesis: Past advances, current state, and future prospects publication-title: Applied Microbiology and Biotechnology doi: 10.1007/s00253-009-2326-8 contributor: fullname: Yoon – volume: 23 start-page: 161 year: 2010 end-page: 175 ident: CR5 article-title: 87–22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant–microbe interactions publication-title: Molecular Plant–Microbe Interactions doi: 10.1094/MPMI-23-2-0161 contributor: fullname: Loria – volume: 341 start-page: 1282 year: 2006 end-page: 1297 ident: CR68 article-title: Novel glycosylation methods and their application to natural products synthesis publication-title: Carbohydrate Research doi: 10.1016/j.carres.2006.03.012 contributor: fullname: Toshima – volume: 49 start-page: 560 year: 1996 end-page: 563 ident: CR15 article-title: Epothilones A and B: Antifungal and cytotoxic compounds from (Myxobacteria). Production, physicochemical and biological properties publication-title: The Journal of Antibiotics doi: 10.7164/antibiotics.49.560 contributor: fullname: Reichenbach – volume: 9 start-page: 624 year: 2008 end-page: 633 ident: CR47 article-title: Glycosylated derivatives of steffimycin: Insights into the role of the sugar moieties for the biological activity publication-title: ChemBioChem doi: 10.1002/cbic.200700610 contributor: fullname: Salas – volume: 190 start-page: 4050 year: 2008 end-page: 4060 ident: CR46 article-title: Genome sequence of the streptomycin-producing microorganism IFO 13350 publication-title: Journal of Bacteriology doi: 10.1128/JB.00204-08 contributor: fullname: Horinouchi – volume: 14 start-page: 99 year: 1997 end-page: 110 ident: CR71 article-title: The role of carbohydrates in biologically active natural products publication-title: Natural Product Reports doi: 10.1039/np9971400099 contributor: fullname: Weymouth-Wilson – volume: 278 start-page: 47483 year: 2003 end-page: 47490 ident: CR72 article-title: GDP-mannose 3′,5′-epimerase forms GDP-L-gulose, a putative intermediate for the de novo biosynthesis of vitamin C in plants publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M309135200 contributor: fullname: Van Montagu – volume: 141 start-page: 181 year: 2009 end-page: 188 ident: CR55 article-title: Engineering of plant-specific phenylpropanoids biosynthesis in publication-title: Journal of Biotechnology doi: 10.1016/j.jbiotec.2009.03.013 contributor: fullname: Yoon – volume: 7 start-page: 1085 year: 1995 end-page: 1097 ident: CR11 article-title: Stress-induced phenylpropanoid metabolism publication-title: Plant Cell doi: 10.1105/tpc.7.7.1085 contributor: fullname: Paiva – volume: 45 start-page: 1321 year: 2006 end-page: 1330 ident: CR42 article-title: Heterologous production of epothilone C and D in publication-title: Biochemistry doi: 10.1021/bi052075r contributor: fullname: Kennedy – year: 2015 ident: CR8 publication-title: Antibacterial agents: Antibacterials and antifungals contributor: fullname: Bryskier – year: 1975 ident: CR22 publication-title: The flavonoids doi: 10.1007/978-1-4899-2909-9 contributor: fullname: Mabry – volume: 7 start-page: 843 year: 2011 end-page: 852 ident: CR58 article-title: Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation publication-title: Nature Chemical Biology doi: 10.1038/nchembio.671 contributor: fullname: Yoon – volume: 14 start-page: 5824 year: 2012 end-page: 5827 ident: CR34 article-title: Heterologous production of 4- -demethylbarbamide, a marine cyanobacterial natural product publication-title: Organic Letters doi: 10.1021/ol302575h contributor: fullname: Yoon – volume: 98 start-page: 12215 year: 2001 end-page: 12220 ident: CR48 article-title: Genome sequence of an industrial microorganism : Deducing the ability of producing secondary metabolites publication-title: Proceedings of the National Academy of Sciences USA doi: 10.1073/pnas.211433198 contributor: fullname: Hattori – volume: 81 start-page: 109 year: 2008 ident: 638_CR54 publication-title: Applied Microbiology and Biotechnology doi: 10.1007/s00253-008-1674-0 contributor: fullname: SR Park – volume: 77 start-page: 4912 year: 2011 ident: 638_CR18 publication-title: Applied and Environmental Microbiology doi: 10.1128/AEM.02527-10 contributor: fullname: AR Han – volume: 93 start-page: 1147 year: 2012 ident: 638_CR20 publication-title: Applied Microbiology and Biotechnology doi: 10.1007/s00253-011-3592-9 contributor: fullname: AR Han – volume: 48 start-page: 4688 year: 2009 ident: 638_CR23 publication-title: Angewandte Chemie International Edition doi: 10.1002/anie.200806121 contributor: fullname: C Hertweck – volume: 7 start-page: 843 year: 2011 ident: 638_CR58 publication-title: Nature Chemical Biology doi: 10.1038/nchembio.671 contributor: fullname: JW Park – volume: 21 start-page: 613 year: 2011 ident: 638_CR19 publication-title: Journal of Microbiology and Biotechnology doi: 10.1007/s00253-010-2890-y contributor: fullname: AR Han – volume: 72 start-page: 763 year: 2006 ident: 638_CR29 publication-title: Applied Microbiology and Biotechnology doi: 10.1007/s00253-006-0318-5 contributor: fullname: WS Jung – volume: 76 start-page: 18 year: 1997 ident: 638_CR2 publication-title: Pharmacology and Therapeutics doi: 10.1016/S0163-7258(97)00096-X contributor: fullname: F Arcamone – volume: 28 start-page: 125 year: 2011 ident: 638_CR77 publication-title: Natural Product Reports doi: 10.1039/C0NP00037J contributor: fullname: H Zhang – volume: 7 start-page: 1085 year: 1995 ident: 638_CR11 publication-title: Plant Cell doi: 10.1105/tpc.7.7.1085 contributor: fullname: RA Dixon – volume: 9 start-page: 624 year: 2008 ident: 638_CR47 publication-title: ChemBioChem doi: 10.1002/cbic.200700610 contributor: fullname: C Olano – volume: 74 start-page: 1972 year: 2008 ident: 638_CR31 publication-title: Applied and Environmental Microbiology doi: 10.1128/AEM.02296-07 contributor: fullname: WS Jung – volume: 20 start-page: 288 year: 2003 ident: 638_CR64 publication-title: Natural Product Reports doi: 10.1039/b109542k contributor: fullname: K Springob – volume: 429 start-page: 204 year: 2004 ident: 638_CR33 publication-title: Archives of Biochemistry and Biophysics doi: 10.1016/j.abb.2004.06.009 contributor: fullname: MK Kharel – volume: 69 start-page: 938 year: 2006 ident: 638_CR12 publication-title: Journal of Natural Products doi: 10.1021/np050523q contributor: fullname: PM Flatt – volume-title: The flavonoids year: 1975 ident: 638_CR22 doi: 10.1007/978-1-4899-2909-9 contributor: fullname: JB Harborne – volume: 3 start-page: 15 year: 2001 ident: 638_CR74 publication-title: Metabolic Engineering doi: 10.1006/mben.2000.0167 contributor: fullname: Y Xue – volume: 49 start-page: 560 year: 1996 ident: 638_CR15 publication-title: The Journal of Antibiotics doi: 10.7164/antibiotics.49.560 contributor: fullname: K Gerth – volume: 14 start-page: 5824 year: 2012 ident: 638_CR34 publication-title: Organic Letters doi: 10.1021/ol302575h contributor: fullname: EJ Kim – volume: 5 start-page: 661 year: 1998 ident: 638_CR75 publication-title: Chemistry and Biology doi: 10.1016/S1074-5521(98)90293-9 contributor: fullname: Y Xue – volume: 45 start-page: 2748 year: 2006 ident: 638_CR7 publication-title: Angewandte Chemie International Edition doi: 10.1002/anie.200503195 contributor: fullname: SA Borisova – volume: 19 start-page: 85 year: 2012 ident: 638_CR16 publication-title: Chemistry and Biology doi: 10.1016/j.chembiol.2011.12.014 contributor: fullname: WH Gerwick – volume: 75 start-page: 311 year: 2012 ident: 638_CR44 publication-title: Journal of Natural Products doi: 10.1021/np200906s contributor: fullname: DJ Newman – volume: 517 start-page: 2 year: 2012 ident: 638_CR26 publication-title: Methods in Enzymology contributor: fullname: DA Hopwood – volume: 45 start-page: 1321 year: 2006 ident: 638_CR42 publication-title: Biochemistry doi: 10.1021/bi052075r contributor: fullname: SC Mutka – volume: 296 start-page: 235 year: 2002 ident: 638_CR9 publication-title: Gene doi: 10.1016/S0378-1119(02)00860-0 contributor: fullname: Z Chang – volume: 98 start-page: 12215 year: 2001 ident: 638_CR48 publication-title: Proceedings of the National Academy of Sciences USA doi: 10.1073/pnas.211433198 contributor: fullname: S Omura – volume: 193 start-page: 5055 year: 2011 ident: 638_CR3 publication-title: Journal of Bacteriology doi: 10.1128/JB.05583-11 contributor: fullname: V Barbe – volume: 76 start-page: 1373 year: 2007 ident: 638_CR30 publication-title: Applied Microbiology and Biotechnology doi: 10.1007/s00253-007-1101-y contributor: fullname: WS Jung – volume: 105 start-page: 477 year: 2005 ident: 638_CR38 publication-title: Chemical Reviews doi: 10.1021/cr0301088 contributor: fullname: S Magnet – volume: 20 start-page: 1295 year: 2010 ident: 638_CR57 publication-title: Journal of Microbiology and Biotechnology doi: 10.4014/jmb.1005.05038 contributor: fullname: SR Park – volume: 3 start-page: 759 year: 2014 ident: 638_CR51 publication-title: ACS Synthetic Biology doi: 10.1021/sb300080t contributor: fullname: C Osswald – volume: 46 start-page: 2772 year: 2002 ident: 638_CR28 publication-title: Antimicrobial Agents and Chemotherapy doi: 10.1128/AAC.46.9.2772-2778.2002 contributor: fullname: B Julien – volume: 105 start-page: 8399 year: 2008 ident: 638_CR53 publication-title: Proceedings of the National Academy of Sciences USA doi: 10.1073/pnas.0803164105 contributor: fullname: JW Park – volume: 145 start-page: 855 year: 1999 ident: 638_CR13 publication-title: Microbiology doi: 10.1099/13500872-145-4-855 contributor: fullname: R Fouces – volume: 5 start-page: 391 year: 1998 ident: 638_CR1 publication-title: Current Medicinal Chemistry doi: 10.2174/0929867305666220319104359 contributor: fullname: F Arcamone – volume-title: Antibacterial agents: Antibacterials and antifungals year: 2015 ident: 638_CR8 contributor: fullname: A Bryskier – volume-title: Streptomyces in nature and medicine: The antibiotic markers year: 2007 ident: 638_CR25 contributor: fullname: DA Hopwood – volume: 42 start-page: 1136 year: 2007 ident: 638_CR52 publication-title: Journal of Mass Spectrometry doi: 10.1002/jms.1240 contributor: fullname: JW Park – volume: 141 start-page: 181 year: 2009 ident: 638_CR55 publication-title: Journal of Biotechnology doi: 10.1016/j.jbiotec.2009.03.013 contributor: fullname: SR Park – volume: 98 start-page: 3701 year: 2014 ident: 638_CR32 publication-title: Applied Microbiology and Biotechnology doi: 10.1007/s00253-013-5503-8 contributor: fullname: WS Jung – volume: 341 start-page: 1282 year: 2006 ident: 638_CR68 publication-title: Carbohydrate Research doi: 10.1016/j.carres.2006.03.012 contributor: fullname: K Toshima – volume: 278 start-page: 47483 year: 2003 ident: 638_CR72 publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M309135200 contributor: fullname: BA Wolucka – volume: 12 start-page: 527 year: 2005 ident: 638_CR37 publication-title: Chemistry and Biology doi: 10.1016/j.chembiol.2005.02.016 contributor: fullname: W Lu – volume: 129 start-page: 10546 year: 2007 ident: 638_CR36 publication-title: Journal of the American Chemical Society doi: 10.1021/ja072909o contributor: fullname: C Leimkuhler – volume: 85 start-page: 1227 year: 2010 ident: 638_CR56 publication-title: Applied Microbiology and Biotechnology doi: 10.1007/s00253-009-2326-8 contributor: fullname: SR Park – volume: 6 start-page: 463 year: 1963 ident: 638_CR70 publication-title: Journal of Medicinal Chemistry doi: 10.1021/jm00340a034 contributor: fullname: MJ Weinstein – volume: 28 start-page: 1811 year: 2011 ident: 638_CR14 publication-title: Natural Product Reports doi: 10.1039/c1np00045d contributor: fullname: RW Gantt – volume: 23 start-page: 161 year: 2010 ident: 638_CR5 publication-title: Molecular Plant–Microbe Interactions doi: 10.1094/MPMI-23-2-0161 contributor: fullname: DR Bignell – volume: 21 start-page: 526 year: 2003 ident: 638_CR27 publication-title: Nature Biotechnology doi: 10.1038/nbt820 contributor: fullname: H Ikeda – volume: 21 start-page: 1143 year: 2011 ident: 638_CR59 publication-title: Journal of Microbiology and Biotechnology doi: 10.4014/jmb.1108.08012 contributor: fullname: SR Park – volume: 15 start-page: 219 year: 2007 ident: 638_CR61 publication-title: Trends in Microbiology doi: 10.1016/j.tim.2007.03.004 contributor: fullname: JA Salas – volume: 417 start-page: 141 year: 2002 ident: 638_CR4 publication-title: Nature doi: 10.1038/417141a contributor: fullname: SD Bentley – volume: 55 start-page: 4912 year: 1990 ident: 638_CR17 publication-title: The Journal of Organic Chemistry doi: 10.1021/jo00303a029 contributor: fullname: SP Gunasekera – volume: 238 start-page: 391 year: 2004 ident: 638_CR24 publication-title: FEMS Microbiology Letters contributor: fullname: JS Hong – volume: 59 start-page: 427 year: 1996 ident: 638_CR50 publication-title: Journal of Natural Products doi: 10.1021/np960085a contributor: fullname: J Orjala – volume-title: The aminoglycosides: Microbiology, clinical use and toxicology year: 1982 ident: 638_CR43 contributor: fullname: TL Nagabhushan – volume: 30 start-page: 1012 year: 1977 ident: 638_CR10 publication-title: The Journal of Antibiotics doi: 10.7164/antibiotics.30.1012 contributor: fullname: JW Corcoran – volume: 30 start-page: 1121 year: 2013 ident: 638_CR49 publication-title: Natural Product Reports doi: 10.1039/c3np70034h contributor: fullname: SE Ongley – volume: 30 start-page: 1391 year: 2013 ident: 638_CR65 publication-title: Natural Product Reports doi: 10.1039/c3np70060g contributor: fullname: DC Stevens – volume: 7 start-page: 285 year: 2003 ident: 638_CR62 publication-title: Current Opinion in Chemical Biology doi: 10.1016/S1367-5931(03)00020-6 contributor: fullname: B Shen – volume: 55 start-page: 481 year: 2000 ident: 638_CR21 publication-title: Phyotochemistry doi: 10.1016/S0031-9422(00)00235-1 contributor: fullname: JB Harborne – volume: 121 start-page: 9881 year: 1999 ident: 638_CR78 publication-title: Journal of the American Chemical Society doi: 10.1021/ja992810k contributor: fullname: L Zhao – volume: 69 start-page: 847 year: 2006 ident: 638_CR35 publication-title: Journal of Natural Products doi: 10.1021/np060026p contributor: fullname: SK Lee – volume: 403 start-page: 571 year: 2000 ident: 638_CR73 publication-title: Nature doi: 10.1038/35000624 contributor: fullname: Y Xue – volume: 7 start-page: 97 year: 2000 ident: 638_CR41 publication-title: Chemistry and Biology doi: 10.1016/S1074-5521(00)00075-2 contributor: fullname: I Molnár – volume: 12 start-page: 175 year: 2011 ident: 638_CR60 publication-title: BMC Genomics doi: 10.1186/1471-2164-12-175 contributor: fullname: ST Pullan – volume: 56 start-page: 185 year: 2004 ident: 638_CR40 publication-title: Pharmacological Reviews doi: 10.1124/pr.56.2.6 contributor: fullname: G Minotti – volume: 190 start-page: 4050 year: 2008 ident: 638_CR46 publication-title: Journal of Bacteriology doi: 10.1128/JB.00204-08 contributor: fullname: Y Ohnishi – volume: 287 start-page: 640 year: 2000 ident: 638_CR66 publication-title: Science doi: 10.1126/science.287.5453.640 contributor: fullname: L Tang – volume: 168 start-page: 142 year: 2013 ident: 638_CR63 publication-title: Journal of Biotechnology doi: 10.1016/j.jbiotec.2013.05.014 contributor: fullname: PB Shinde – volume: 55 start-page: 2325 year: 1995 ident: 638_CR6 publication-title: Cancer Research contributor: fullname: DM Bollag – volume: 95 start-page: 12111 year: 1998 ident: 638_CR76 publication-title: Proceedings of the National Academy of Sciences USA doi: 10.1073/pnas.95.21.12111 contributor: fullname: Y Xue – volume: 14 start-page: 99 year: 1997 ident: 638_CR71 publication-title: Natural Product Reports doi: 10.1039/np9971400099 contributor: fullname: AC Weymouth-Wilson – volume: 76 start-page: 1357 year: 2007 ident: 638_CR67 publication-title: Applied Microbiology and Biotechnology doi: 10.1007/s00253-007-1096-4 contributor: fullname: LP Thapa – volume: 192 start-page: 4526 year: 2010 ident: 638_CR69 publication-title: Journal of Bacteriology doi: 10.1128/JB.00596-10 contributor: fullname: XJ Wang – volume: 2 start-page: 212 year: 2010 ident: 638_CR39 publication-title: Genome Biology and Evolution doi: 10.1093/gbe/evq013 contributor: fullname: MH Medema
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Snippet	The heterologous expression of biosynthetic pathways is an indispensable tool for drug discovery and development from natural products. Streptomyces venezuelae... The heterologous expression of biosynthetic pathways is an indispensable tool for drug discovery and development from natural products. Streptomyces venezuelae... The heterologous expression of biosyntheticpathways is an indispensable tool for drug discovery anddevelopment from natural products. Streptomycesvenezuelae is...
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SubjectTerms	Animals biochemical pathways derivatization Drug Discovery - methods drugs genetic engineering Genetic Engineering - methods genetically modified organisms heterologous gene expression host strains Humans Medicine multigene family mutants Pharmacology/Toxicology Pharmacy products Review Streptomyces Streptomyces - genetics Streptomyces - metabolism Streptomyces venezuelae 약학
Title	Developing Streptomyces venezuelae as a cell factory for the production of small molecules used in drug discovery
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