The Androgen Receptor Is Significantly Associated with Vascular Endothelial Growth Factor and Hypoxia Sensing via Hypoxia-Inducible Factors HIF-1a, HIF-2a, and the Prolyl Hydroxylases in Human Prostate Cancer

Purpose: Hypoxia regulates key biological processes including angiogenesis via the transcription factor, hypoxia-inducible factor (HIF). In prostate cancer, angiogenesis is also influenced by androgens, and recent cell line studies suggest that this effect is partly mediated by HIF. The study aimed...

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Bibliographic Details
Published in:	Clinical cancer research Vol. 11; no. 21; pp. 7658 - 7663
Main Authors:	BEADY, Jane L, FOX, Stephen B, CHENG HAN, CAMPO, Leticia, TURLEY, Helen, KANGA, Suresh, MALONE, Peter R, HARRIS, Adrian L
Format:	Journal Article
Language:	English
Published:	Philadelphia, PA American Association for Cancer Research 01-11-2005
Subjects:	Aged Androgens Angiogenesis Antineoplastic agents Basic Helix-Loop-Helix Transcription Factors - biosynthesis Biological and medical sciences Disease Progression Disease-Free Survival Gene Expression Regulation, Neoplastic Gynecology. Andrology. Obstetrics Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis Immunohistochemistry Male Male genital diseases Medical sciences Middle Aged Models, Statistical Neovascularization, Pathologic Nephrology. Urinary tract diseases Pharmacology. Drug treatments Procollagen-Proline Dioxygenase - biosynthesis Proportional Hazards Models Prostate-Specific Antigen - biosynthesis Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Receptors, Androgen - biosynthesis Recurrence Tumors Tumors of the urinary system Urinary tract. Prostate gland Vascular Endothelial Growth Factor A - biosynthesis Vascular Endothelial Growth Factor A - metabolism Human Oxygen Urinary system disease Prostate disease Enzyme Hydroxylase Malignant tumor Vascular endothelium growth factor Androgen receptor Hypoxia Oxidoreductases Male genital diseases Prostate cancer Hormonal receptor
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