Sensitivity enhancement based on application of multi-pass interferometry in phase-sensitive surface plasmon resonance biosensor

A novel design of multi-pass surface plasmon resonance (SPR) biosensor with differential phase interrogation based on multi-pass interferometry is presented. This new configuration provides an intrinsic phase amplification effect of over twofold by placing the SPR sensor head in a signal arm of the...

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Published in:Optics communications Vol. 275; no. 2; pp. 491 - 496
Main Authors: Ho, H.P., Yuan, W., Wong, C.L., Wu, S.Y., Suen, Y.K., Kong, S.K., Lin, Chinlon
Format: Journal Article
Language:English
Published: Amsterdam Elsevier B.V 15-07-2007
Elsevier Science
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Abstract A novel design of multi-pass surface plasmon resonance (SPR) biosensor with differential phase interrogation based on multi-pass interferometry is presented. This new configuration provides an intrinsic phase amplification effect of over twofold by placing the SPR sensor head in a signal arm of the interferometer so that the interrogating optical beam will traverse the sensor surface infinite number of times. Experimental interferometers based on the Michelson and Fabry–Perot configurations have been employed to experimentally verify this amplification effect when they were compared with Mach–Zehnder configuration, results obtained from salt–water mixtures, antibody–antigen, and protein–DNA binding reaction confirmed the expected phase measurement enhancement, thus leading to the possibility of direct detection of small sized bio-molecules using SPR.
AbstractList A novel design of multi-pass surface plasmon resonance (SPR) biosensor with differential phase interrogation based on multi-pass interferometry is presented. This new configuration provides an intrinsic phase amplification effect of over twofold by placing the SPR sensor head in a signal arm of the interferometer so that the interrogating optical beam will traverse the sensor surface infinite number of times. Experimental interferometers based on the Michelson and Fabry–Perot configurations have been employed to experimentally verify this amplification effect when they were compared with Mach–Zehnder configuration, results obtained from salt–water mixtures, antibody–antigen, and protein–DNA binding reaction confirmed the expected phase measurement enhancement, thus leading to the possibility of direct detection of small sized bio-molecules using SPR.
Author Lin, Chinlon
Suen, Y.K.
Kong, S.K.
Ho, H.P.
Yuan, W.
Wong, C.L.
Wu, S.Y.
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Issue 2
Keywords Surface plasmon resonance
Fabry–Perot interferometry
Phase interrogation
Biosensor
Proteins
Light interferometry
Phase measurement
Fabry-Perot interferometry
DNA
Biosensors
Experimental study
Language English
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Snippet A novel design of multi-pass surface plasmon resonance (SPR) biosensor with differential phase interrogation based on multi-pass interferometry is presented....
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StartPage 491
SubjectTerms Biological and medical sciences
Biosensor
Biosensors
Biotechnology
Exact sciences and technology
Fabry–Perot interferometry
Fundamental and applied biological sciences. Psychology
Instruments, apparatus, components and techniques common to several branches of physics and astronomy
Interferometers
Methods. Procedures. Technologies
Optical instruments, equipment and techniques
Phase interrogation
Physics
Surface plasmon resonance
Various methods and equipments
Title Sensitivity enhancement based on application of multi-pass interferometry in phase-sensitive surface plasmon resonance biosensor
URI https://dx.doi.org/10.1016/j.optcom.2007.03.067
Volume 275
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