Sensitivity enhancement based on application of multi-pass interferometry in phase-sensitive surface plasmon resonance biosensor
A novel design of multi-pass surface plasmon resonance (SPR) biosensor with differential phase interrogation based on multi-pass interferometry is presented. This new configuration provides an intrinsic phase amplification effect of over twofold by placing the SPR sensor head in a signal arm of the...
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Published in: | Optics communications Vol. 275; no. 2; pp. 491 - 496 |
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Elsevier B.V
15-07-2007
Elsevier Science |
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Abstract | A novel design of multi-pass surface plasmon resonance (SPR) biosensor with differential phase interrogation based on multi-pass interferometry is presented. This new configuration provides an intrinsic phase amplification effect of over twofold by placing the SPR sensor head in a signal arm of the interferometer so that the interrogating optical beam will traverse the sensor surface infinite number of times. Experimental interferometers based on the Michelson and Fabry–Perot configurations have been employed to experimentally verify this amplification effect when they were compared with Mach–Zehnder configuration, results obtained from salt–water mixtures, antibody–antigen, and protein–DNA binding reaction confirmed the expected phase measurement enhancement, thus leading to the possibility of direct detection of small sized bio-molecules using SPR. |
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AbstractList | A novel design of multi-pass surface plasmon resonance (SPR) biosensor with differential phase interrogation based on multi-pass interferometry is presented. This new configuration provides an intrinsic phase amplification effect of over twofold by placing the SPR sensor head in a signal arm of the interferometer so that the interrogating optical beam will traverse the sensor surface infinite number of times. Experimental interferometers based on the Michelson and Fabry–Perot configurations have been employed to experimentally verify this amplification effect when they were compared with Mach–Zehnder configuration, results obtained from salt–water mixtures, antibody–antigen, and protein–DNA binding reaction confirmed the expected phase measurement enhancement, thus leading to the possibility of direct detection of small sized bio-molecules using SPR. |
Author | Lin, Chinlon Suen, Y.K. Kong, S.K. Ho, H.P. Yuan, W. Wong, C.L. Wu, S.Y. |
Author_xml | – sequence: 1 givenname: H.P. surname: Ho fullname: Ho, H.P. email: hpho@ee.cuhk.edu.hk organization: Center for Advanced Research in Photonics, Department of Electronic Engineering, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China – sequence: 2 givenname: W. surname: Yuan fullname: Yuan, W. organization: Center for Advanced Research in Photonics, Department of Electronic Engineering, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China – sequence: 3 givenname: C.L. surname: Wong fullname: Wong, C.L. organization: Center for Advanced Research in Photonics, Department of Electronic Engineering, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China – sequence: 4 givenname: S.Y. surname: Wu fullname: Wu, S.Y. organization: Center for Advanced Research in Photonics, Department of Electronic Engineering, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China – sequence: 5 givenname: Y.K. surname: Suen fullname: Suen, Y.K. organization: Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China – sequence: 6 givenname: S.K. surname: Kong fullname: Kong, S.K. organization: Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China – sequence: 7 givenname: Chinlon surname: Lin fullname: Lin, Chinlon organization: Center for Advanced Research in Photonics, Department of Electronic Engineering, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China |
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Keywords | Surface plasmon resonance Fabry–Perot interferometry Phase interrogation Biosensor Proteins Light interferometry Phase measurement Fabry-Perot interferometry DNA Biosensors Experimental study |
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SubjectTerms | Biological and medical sciences Biosensor Biosensors Biotechnology Exact sciences and technology Fabry–Perot interferometry Fundamental and applied biological sciences. Psychology Instruments, apparatus, components and techniques common to several branches of physics and astronomy Interferometers Methods. Procedures. Technologies Optical instruments, equipment and techniques Phase interrogation Physics Surface plasmon resonance Various methods and equipments |
Title | Sensitivity enhancement based on application of multi-pass interferometry in phase-sensitive surface plasmon resonance biosensor |
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