Incorporation of ceramide 3B in dermatocosmetic emulsions: effect on the transepidermal water loss of sodium lauryl sulphate-damaged skin

• Published in: Journal of the European Academy of Dermatology and Venereology Vol. 14; no. 4; pp. 272 - 279
• Main Authors: De Paepe, Kristien, Derde, Marie-Paule, Roseeuw, Diane, Rogiers, Vera
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01-07-2000
• Subjects: Adult; Analysis of Variance; barrier function; ceramide 3B; Ceramides - therapeutic use; Dermatitis, Irritant - drug therapy; Emulsions - chemistry; Female; Forearm; galenic formulations; Humans; Irritants - adverse effects; penetration enhancers; Skin Care - methods; Skin Physiological Phenomena; Sodium Dodecyl Sulfate - pharmacology; sodium lauryl sulphate-damaged skin; Surface-Active Agents - pharmacology; transepidermal water loss; Water Loss, Insensible - drug effects
• ISSN: 0926-9959; 1468-3083
• DOI: 10.1046/j.1468-3083.2000.00103.x

Background
In previous work we reported on the efficacy of cosmetic body lotions enriched with skin‐identical lipids to reduce the transepidermal water loss (TEWL) of ageing and sodium lauryl sulphate (SLS)‐damaged skin. The observations made depended on the experimental design and clearly raised the question of the importance of the galenic formulation of skin ceramide‐containing products.
Objectives
The aim of the present work was to study the different galenic forms in which ceramide 3B (0.2% w/v) can be incorporated into common o/w emulsions. In addition, we investigated whether supplementation of skin care products with ceramide 3B enriched with penetration enhancers and coemulsifiers could exert a beneficial effect on barrier function, done by measuring their effects on the TEWL of SLS‐induced scaly skin.
Results
We found that the technique of incorporating ceramide 3B into the o/w emulsions was important for their final stability. However, no additional positive effect on the TEWL values of SLS‐damaged skin could be observed when the efficacy of the ceramide‐containing emulsions was compared with that of proper controls.
Conclusions
Although suitable galenic formulas were developed, no positive effect on TEWL could be observed when ceramide 3B was added in a final concentration of 0.2% (w/v) to different o/w emulsions and applied to SLS‐damaged skin.