A model for influence of exercise on formation and growth of tissue bubbles during altitude decompression

• Published in: American journal of physiology. Regulatory, integrative and comparative physiology Vol. 279; no. 6; p. R2304
• Main Authors: Foster, P P, Feiveson, A H, Glowinski, R, Izygon, M, Boriek, A M
• Format: Journal Article
• Language: English
• Published: United States 01-12-2000
• Subjects: Altitude; Computer Simulation; Decompression; Exercise - physiology; Gases - metabolism; Humans; Models, Biological; Oxygen Consumption; Poisson Distribution; Respiratory Mechanics; Software; Stochastic Processes; Thermodynamics
• ISSN: 0363-6119
• DOI: 10.1152/ajpregu.2000.279.6.r2304

In response to exercise performed before or after altitude decompression, physiological changes are suspected to affect the formation and growth of decompression bubbles. We hypothesized that the work to change the size of a bubble is done by gas pressure gradients in a macro- and microsystem of thermodynamic forces and that the number of bubbles formed through time follows a Poisson process. We modeled the influence of tissue O(2) consumption on bubble dynamics in the O(2) transport system in series against resistances, from the alveolus to the microsystem containing the bubble and its surrounding tissue shell. Realistic simulations of experimental decompression procedures typical of actual extravehicular activities were obtained. Results suggest that exercise-induced elevation of O(2) consumption at altitude leads to bubble persistence in tissues. At the same time, exercise-enhanced perfusion leads to an overall suppression of bubble growth. The total volume of bubbles would be reduced unless increased tissue motion simultaneously raises the rate of bubble formation through cavitation processes, thus maintaining or increasing total bubble volume, despite the exercise.