cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics

The retromer complex is required for the efficient endosome-to-Golgi retrieval of the CIMPR, sortilin, SORL1, wntless and other physiologically important membrane proteins. Retromer comprises two protein complexes that act together in endosome-to-Golgi retrieval; the cargo-selective complex is a tri...

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Bibliographic Details
Published in:	Journal of cell science Vol. 123; no. 21; pp. 3703 - 3717
Main Authors:	Harbour, Michael E, Breusegem, Sophia Y.A, Antrobus, Robin, Freeman, Caroline, Reid, Evan, Seaman, Matthew N.J
Format:	Journal Article
Language:	English
Published:	England The Company of Biologists Limited 01-11-2010 Company of Biologists
Subjects:	Axons - pathology Carrier Proteins - genetics Carrier Proteins - metabolism Dimerization Endosomes - metabolism Endosomes - ultrastructure Golgi Apparatus - metabolism HeLa Cells Humans Multiprotein Complexes - metabolism Mutation - genetics Paraplegia - genetics Paraplegia - metabolism Paraplegia - pathology Protein Binding Protein Interaction Domains and Motifs - genetics Protein Transport Proteins - genetics Proteins - metabolism Sorting Nexins - metabolism Vesicular Transport Proteins - genetics Vesicular Transport Proteins - metabolism
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