Chemical composition and biological activities of Bocageopsis multiflora essential oil

• Published in: The Journal of essential oil research Vol. 26; no. 3; pp. 161 - 165
• Main Authors: Oliveira, Edinilze S.C, Amaral, Ana Claudia F, Lima, Emerson S, Silva, Jefferson Rocha de A
• Format: Journal Article
• Language: English
• Published: Taylor & Francis 04-05-2014
• Subjects: Annonaceae; bioactive properties; Bocageopsis multiflora; chemical composition; coagulation; drugs; dry season; essential oil; essential oils; gas chromatography-mass spectrometry; inhibitory concentration 50; ionization; leaves; Leishmania amazonensis; leishmaniasis; macrophages; mice; oils; prothrombin; sesquiterpenes; spathulenol; thromboplastin; wet season
• ISSN: 2163-8152; 1041-2905; 2163-8152
• DOI: 10.1080/10412905.2013.840809

This article describes, for the first time, the chemical constituents of the essential oils from fresh leaves of Bocageopsis multiflora , collected in two seasons, and some of its biological activities. The oils were analyzed by gas chromatography–flame ionization detector (GC–FID) and gas chromatography–mass spectrometry (MS) and showed a high proportion of sesquiterpenes. The main constituent of the oil collected in the rainy season was bisabolene (13.2%), while the main constituent in the dry season was spathulenol (16.2%). The highest yield (0.3%) was obtained for the oil collected in the rainy season, which was assayed against Leishmania amazonensis promastigote forms, exhibiting significant activity (IC ₅₀ of 14.6 μg/mL). Comparison between the oil and the reference drug (pentamidine isethionate) showed non-toxic effects for mice peritoneal macrophages treated at IC ₅₀ of each sample. The results obtained in the prothrombin time and activated partial thromboplastin time tests indicated that the oil acted as a procoagulant, causing activation of coagulation in both pathways.